| Full name: transmembrane channel like 6 | Alias Symbol: LAK-4P|EVIN1 | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 11322 | HGNC ID: HGNC:18021 | Ensembl Gene: ENSG00000141524 | OMIM ID: 605828 |
| Drug and gene relationship at DGIdb | |||
Expression of TMC6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TMC6 | 11322 | 204328_at | 0.9046 | 0.0854 | |
| GSE20347 | TMC6 | 11322 | 204328_at | 0.0149 | 0.9334 | |
| GSE23400 | TMC6 | 11322 | 204328_at | 0.2570 | 0.0000 | |
| GSE26886 | TMC6 | 11322 | 204328_at | 0.4815 | 0.0227 | |
| GSE29001 | TMC6 | 11322 | 204328_at | 0.2660 | 0.3170 | |
| GSE38129 | TMC6 | 11322 | 204328_at | 0.3507 | 0.0591 | |
| GSE45670 | TMC6 | 11322 | 204328_at | 0.7298 | 0.0000 | |
| GSE53622 | TMC6 | 11322 | 32132 | 0.4518 | 0.0001 | |
| GSE53624 | TMC6 | 11322 | 32132 | 0.3576 | 0.0000 | |
| GSE63941 | TMC6 | 11322 | 204328_at | 2.6113 | 0.0009 | |
| GSE77861 | TMC6 | 11322 | 214958_s_at | -0.2516 | 0.2121 | |
| GSE97050 | TMC6 | 11322 | A_23_P101013 | 0.6766 | 0.1494 | |
| SRP007169 | TMC6 | 11322 | RNAseq | 0.4584 | 0.1724 | |
| SRP008496 | TMC6 | 11322 | RNAseq | -0.1095 | 0.6822 | |
| SRP064894 | TMC6 | 11322 | RNAseq | 1.1236 | 0.0000 | |
| SRP133303 | TMC6 | 11322 | RNAseq | 0.3058 | 0.1414 | |
| SRP159526 | TMC6 | 11322 | RNAseq | 0.1413 | 0.7018 | |
| SRP193095 | TMC6 | 11322 | RNAseq | 0.4057 | 0.0066 | |
| SRP219564 | TMC6 | 11322 | RNAseq | 0.4043 | 0.4361 | |
| TCGA | TMC6 | 11322 | RNAseq | 0.4193 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by TMC6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TMC6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TMC6 | 11322 | 5 | 4 | 21 | |
| GSE20123 | TMC6 | 11322 | 5 | 4 | 21 | |
| GSE43470 | TMC6 | 11322 | 3 | 4 | 36 | |
| GSE46452 | TMC6 | 11322 | 33 | 0 | 26 | |
| GSE47630 | TMC6 | 11322 | 8 | 1 | 31 | |
| GSE54993 | TMC6 | 11322 | 2 | 5 | 63 | |
| GSE54994 | TMC6 | 11322 | 10 | 4 | 39 | |
| GSE60625 | TMC6 | 11322 | 6 | 0 | 5 | |
| GSE74703 | TMC6 | 11322 | 3 | 2 | 31 | |
| GSE74704 | TMC6 | 11322 | 4 | 3 | 13 | |
| TCGA | TMC6 | 11322 | 31 | 8 | 57 |
Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.
Somatic mutations of TMC6:
Generating mutation plots.
Highly correlated genes for TMC6:
Showing top 20/319 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TMC6 | RCC2 | 0.722235 | 5 | 0 | 5 |
| TMC6 | TRIM28 | 0.70729 | 3 | 0 | 3 |
| TMC6 | ARHGEF19 | 0.692404 | 4 | 0 | 4 |
| TMC6 | SLC5A12 | 0.677321 | 4 | 0 | 4 |
| TMC6 | ST14 | 0.669586 | 6 | 0 | 5 |
| TMC6 | PRRC2A | 0.6684 | 3 | 0 | 3 |
| TMC6 | CNOT3 | 0.665806 | 3 | 0 | 3 |
| TMC6 | OTX1 | 0.660793 | 3 | 0 | 3 |
| TMC6 | SMPDL3B | 0.659313 | 3 | 0 | 3 |
| TMC6 | ZNF786 | 0.658475 | 4 | 0 | 3 |
| TMC6 | LSR | 0.643866 | 10 | 0 | 8 |
| TMC6 | POU4F1 | 0.641809 | 3 | 0 | 3 |
| TMC6 | FGFR3 | 0.638228 | 6 | 0 | 5 |
| TMC6 | APOBEC3G | 0.636302 | 3 | 0 | 3 |
| TMC6 | ITGB7 | 0.635248 | 6 | 0 | 4 |
| TMC6 | FBLL1 | 0.634571 | 3 | 0 | 3 |
| TMC6 | CDK18 | 0.632889 | 4 | 0 | 3 |
| TMC6 | EPN1 | 0.632624 | 3 | 0 | 3 |
| TMC6 | SMPD3 | 0.628669 | 4 | 0 | 3 |
| TMC6 | SNX8 | 0.628038 | 4 | 0 | 3 |
For details and further investigation, click here
