| Full name: isochorismatase domain containing 2 | Alias Symbol: FLJ23469 | ||
| Type: protein-coding gene | Cytoband: 19q13.42 | ||
| Entrez ID: 79763 | HGNC ID: HGNC:26278 | Ensembl Gene: ENSG00000063241 | OMIM ID: 612928 |
| Drug and gene relationship at DGIdb | |||
Expression of ISOC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ISOC2 | 79763 | 218893_at | 0.4880 | 0.1978 | |
| GSE20347 | ISOC2 | 79763 | 218893_at | -0.0690 | 0.5740 | |
| GSE23400 | ISOC2 | 79763 | 218893_at | 0.0267 | 0.6614 | |
| GSE26886 | ISOC2 | 79763 | 218893_at | 0.7396 | 0.0001 | |
| GSE29001 | ISOC2 | 79763 | 218893_at | -0.0669 | 0.7666 | |
| GSE38129 | ISOC2 | 79763 | 218893_at | 0.1502 | 0.4611 | |
| GSE45670 | ISOC2 | 79763 | 218893_at | 0.0472 | 0.7484 | |
| GSE53622 | ISOC2 | 79763 | 31216 | 0.1128 | 0.1672 | |
| GSE53624 | ISOC2 | 79763 | 31216 | 0.2889 | 0.0000 | |
| GSE63941 | ISOC2 | 79763 | 218893_at | 0.5001 | 0.1478 | |
| GSE77861 | ISOC2 | 79763 | 218893_at | -0.2267 | 0.2322 | |
| GSE97050 | ISOC2 | 79763 | A_24_P99795 | 0.0999 | 0.6815 | |
| SRP007169 | ISOC2 | 79763 | RNAseq | -0.1502 | 0.7195 | |
| SRP008496 | ISOC2 | 79763 | RNAseq | -0.2898 | 0.2714 | |
| SRP064894 | ISOC2 | 79763 | RNAseq | 1.1321 | 0.0094 | |
| SRP133303 | ISOC2 | 79763 | RNAseq | 0.3942 | 0.0544 | |
| SRP159526 | ISOC2 | 79763 | RNAseq | 0.2366 | 0.3339 | |
| SRP193095 | ISOC2 | 79763 | RNAseq | -0.1838 | 0.2815 | |
| SRP219564 | ISOC2 | 79763 | RNAseq | 0.0502 | 0.9186 | |
| TCGA | ISOC2 | 79763 | RNAseq | 0.0848 | 0.1884 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ISOC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ISOC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ISOC2 | 79763 | 3 | 4 | 23 | |
| GSE20123 | ISOC2 | 79763 | 3 | 3 | 24 | |
| GSE43470 | ISOC2 | 79763 | 3 | 10 | 30 | |
| GSE46452 | ISOC2 | 79763 | 45 | 1 | 13 | |
| GSE47630 | ISOC2 | 79763 | 8 | 6 | 26 | |
| GSE54993 | ISOC2 | 79763 | 17 | 4 | 49 | |
| GSE54994 | ISOC2 | 79763 | 4 | 13 | 36 | |
| GSE60625 | ISOC2 | 79763 | 9 | 0 | 2 | |
| GSE74703 | ISOC2 | 79763 | 3 | 6 | 27 | |
| GSE74704 | ISOC2 | 79763 | 3 | 1 | 16 | |
| TCGA | ISOC2 | 79763 | 19 | 14 | 63 |
Total number of gains: 117; Total number of losses: 62; Total Number of normals: 309.
Somatic mutations of ISOC2:
Generating mutation plots.
Highly correlated genes for ISOC2:
Showing top 20/531 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ISOC2 | SSBP4 | 0.815535 | 3 | 0 | 3 |
| ISOC2 | PACS1 | 0.772171 | 3 | 0 | 3 |
| ISOC2 | TCN2 | 0.72704 | 3 | 0 | 3 |
| ISOC2 | MMP14 | 0.719568 | 3 | 0 | 3 |
| ISOC2 | KRTCAP2 | 0.716533 | 3 | 0 | 3 |
| ISOC2 | ZNF496 | 0.711321 | 3 | 0 | 3 |
| ISOC2 | NAF1 | 0.710286 | 3 | 0 | 3 |
| ISOC2 | CHD4 | 0.707644 | 4 | 0 | 4 |
| ISOC2 | POLR1C | 0.704777 | 3 | 0 | 3 |
| ISOC2 | MYPOP | 0.699949 | 5 | 0 | 5 |
| ISOC2 | HGS | 0.694585 | 3 | 0 | 3 |
| ISOC2 | NPRL2 | 0.693337 | 3 | 0 | 3 |
| ISOC2 | TAB1 | 0.692338 | 4 | 0 | 4 |
| ISOC2 | TESK1 | 0.692198 | 4 | 0 | 3 |
| ISOC2 | ARPC4 | 0.689483 | 4 | 0 | 4 |
| ISOC2 | LDLRAP1 | 0.681569 | 3 | 0 | 3 |
| ISOC2 | CRTC2 | 0.678697 | 4 | 0 | 3 |
| ISOC2 | SEPHS1 | 0.67778 | 4 | 0 | 3 |
| ISOC2 | KCTD13 | 0.674607 | 4 | 0 | 3 |
| ISOC2 | ZNF628 | 0.673764 | 6 | 0 | 5 |
For details and further investigation, click here
