| Full name: dual specificity phosphatase 3 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 1845 | HGNC ID: HGNC:3069 | Ensembl Gene: ENSG00000108861 | OMIM ID: 600183 |
| Drug and gene relationship at DGIdb | |||
DUSP3 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway |
Expression of DUSP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DUSP3 | 1845 | 201536_at | -0.5520 | 0.3553 | |
| GSE20347 | DUSP3 | 1845 | 201536_at | -0.4138 | 0.0004 | |
| GSE23400 | DUSP3 | 1845 | 201536_at | -0.4272 | 0.0000 | |
| GSE26886 | DUSP3 | 1845 | 201536_at | -0.4108 | 0.0055 | |
| GSE29001 | DUSP3 | 1845 | 201536_at | -0.6487 | 0.0010 | |
| GSE38129 | DUSP3 | 1845 | 201536_at | -0.6719 | 0.0000 | |
| GSE45670 | DUSP3 | 1845 | 201536_at | -0.5571 | 0.0001 | |
| GSE53622 | DUSP3 | 1845 | 294 | -0.6800 | 0.0000 | |
| GSE53624 | DUSP3 | 1845 | 294 | -0.5476 | 0.0000 | |
| GSE63941 | DUSP3 | 1845 | 201536_at | -0.2661 | 0.4381 | |
| GSE77861 | DUSP3 | 1845 | 201536_at | 0.0091 | 0.9814 | |
| GSE97050 | DUSP3 | 1845 | A_23_P129956 | -0.8355 | 0.0959 | |
| SRP007169 | DUSP3 | 1845 | RNAseq | -0.7461 | 0.0686 | |
| SRP008496 | DUSP3 | 1845 | RNAseq | -0.9747 | 0.0002 | |
| SRP064894 | DUSP3 | 1845 | RNAseq | -0.3885 | 0.0119 | |
| SRP133303 | DUSP3 | 1845 | RNAseq | -0.1862 | 0.4297 | |
| SRP159526 | DUSP3 | 1845 | RNAseq | -0.6414 | 0.0364 | |
| SRP193095 | DUSP3 | 1845 | RNAseq | -0.5190 | 0.0000 | |
| SRP219564 | DUSP3 | 1845 | RNAseq | -0.7094 | 0.2449 | |
| TCGA | DUSP3 | 1845 | RNAseq | -0.2890 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DUSP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DUSP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DUSP3 | 1845 | 5 | 2 | 23 | |
| GSE20123 | DUSP3 | 1845 | 5 | 2 | 23 | |
| GSE43470 | DUSP3 | 1845 | 1 | 2 | 40 | |
| GSE46452 | DUSP3 | 1845 | 32 | 0 | 27 | |
| GSE47630 | DUSP3 | 1845 | 8 | 1 | 31 | |
| GSE54993 | DUSP3 | 1845 | 3 | 4 | 63 | |
| GSE54994 | DUSP3 | 1845 | 8 | 6 | 39 | |
| GSE60625 | DUSP3 | 1845 | 4 | 0 | 7 | |
| GSE74703 | DUSP3 | 1845 | 1 | 1 | 34 | |
| GSE74704 | DUSP3 | 1845 | 3 | 1 | 16 | |
| TCGA | DUSP3 | 1845 | 23 | 7 | 66 |
Total number of gains: 93; Total number of losses: 26; Total Number of normals: 369.
Somatic mutations of DUSP3:
Generating mutation plots.
Highly correlated genes for DUSP3:
Showing top 20/1114 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DUSP3 | FAM124A | 0.840526 | 3 | 0 | 3 |
| DUSP3 | JMY | 0.795985 | 3 | 0 | 3 |
| DUSP3 | SMAD4 | 0.778128 | 3 | 0 | 3 |
| DUSP3 | JPH2 | 0.776827 | 5 | 0 | 5 |
| DUSP3 | ZNF546 | 0.771267 | 3 | 0 | 3 |
| DUSP3 | FIGN | 0.762708 | 3 | 0 | 3 |
| DUSP3 | SPOPL | 0.758964 | 3 | 0 | 3 |
| DUSP3 | HSPB6 | 0.757971 | 6 | 0 | 6 |
| DUSP3 | SORCS1 | 0.757199 | 4 | 0 | 3 |
| DUSP3 | PPARGC1A | 0.756479 | 6 | 0 | 6 |
| DUSP3 | INMT | 0.749203 | 4 | 0 | 4 |
| DUSP3 | IQUB | 0.747132 | 3 | 0 | 3 |
| DUSP3 | ASB5 | 0.745238 | 5 | 0 | 5 |
| DUSP3 | LSM11 | 0.744463 | 4 | 0 | 3 |
| DUSP3 | FRMD3 | 0.742248 | 4 | 0 | 4 |
| DUSP3 | EEPD1 | 0.741767 | 3 | 0 | 3 |
| DUSP3 | CFL2 | 0.738946 | 5 | 0 | 5 |
| DUSP3 | C16orf86 | 0.73816 | 3 | 0 | 3 |
| DUSP3 | KIAA1107 | 0.73784 | 3 | 0 | 3 |
| DUSP3 | LIMS2 | 0.734065 | 7 | 0 | 6 |
For details and further investigation, click here
