| Full name: RAS p21 protein activator 2 | Alias Symbol: GAP1M | ||
| Type: protein-coding gene | Cytoband: 3q23 | ||
| Entrez ID: 5922 | HGNC ID: HGNC:9872 | Ensembl Gene: ENSG00000155903 | OMIM ID: 601589 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RASA2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway |
Expression of RASA2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASA2 | 5922 | 226392_at | 0.3766 | 0.3802 | |
| GSE20347 | RASA2 | 5922 | 206636_at | -0.0184 | 0.9356 | |
| GSE23400 | RASA2 | 5922 | 206636_at | -0.1749 | 0.0007 | |
| GSE26886 | RASA2 | 5922 | 226392_at | -0.6476 | 0.0050 | |
| GSE29001 | RASA2 | 5922 | 206636_at | -0.3590 | 0.1367 | |
| GSE38129 | RASA2 | 5922 | 206636_at | -0.0281 | 0.9060 | |
| GSE45670 | RASA2 | 5922 | 226392_at | -0.2162 | 0.1357 | |
| GSE53622 | RASA2 | 5922 | 26327 | -0.2243 | 0.0002 | |
| GSE53624 | RASA2 | 5922 | 26327 | -0.5361 | 0.0000 | |
| GSE63941 | RASA2 | 5922 | 226392_at | -0.6272 | 0.2204 | |
| GSE77861 | RASA2 | 5922 | 226392_at | -0.1703 | 0.5949 | |
| GSE97050 | RASA2 | 5922 | A_33_P3287972 | 0.1384 | 0.6564 | |
| SRP007169 | RASA2 | 5922 | RNAseq | -0.8617 | 0.0560 | |
| SRP008496 | RASA2 | 5922 | RNAseq | -0.7253 | 0.0086 | |
| SRP064894 | RASA2 | 5922 | RNAseq | -0.6536 | 0.0217 | |
| SRP133303 | RASA2 | 5922 | RNAseq | 0.0043 | 0.9795 | |
| SRP159526 | RASA2 | 5922 | RNAseq | -0.2192 | 0.5405 | |
| SRP193095 | RASA2 | 5922 | RNAseq | -0.3246 | 0.0156 | |
| SRP219564 | RASA2 | 5922 | RNAseq | -0.3717 | 0.4829 | |
| TCGA | RASA2 | 5922 | RNAseq | 0.0850 | 0.3285 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RASA2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASA2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASA2 | 5922 | 19 | 0 | 11 | |
| GSE20123 | RASA2 | 5922 | 19 | 0 | 11 | |
| GSE43470 | RASA2 | 5922 | 22 | 0 | 21 | |
| GSE46452 | RASA2 | 5922 | 15 | 4 | 40 | |
| GSE47630 | RASA2 | 5922 | 19 | 3 | 18 | |
| GSE54993 | RASA2 | 5922 | 1 | 8 | 61 | |
| GSE54994 | RASA2 | 5922 | 34 | 1 | 18 | |
| GSE60625 | RASA2 | 5922 | 0 | 6 | 5 | |
| GSE74703 | RASA2 | 5922 | 19 | 0 | 17 | |
| GSE74704 | RASA2 | 5922 | 13 | 0 | 7 | |
| TCGA | RASA2 | 5922 | 63 | 4 | 29 |
Total number of gains: 224; Total number of losses: 26; Total Number of normals: 238.
Somatic mutations of RASA2:
Generating mutation plots.
Highly correlated genes for RASA2:
Showing top 20/463 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASA2 | PPP1R3D | 0.837796 | 3 | 0 | 3 |
| RASA2 | APH1A | 0.836546 | 3 | 0 | 3 |
| RASA2 | ZNF121 | 0.833331 | 3 | 0 | 3 |
| RASA2 | LTV1 | 0.809415 | 3 | 0 | 3 |
| RASA2 | EED | 0.808862 | 3 | 0 | 3 |
| RASA2 | ZDHHC6 | 0.781361 | 3 | 0 | 3 |
| RASA2 | TRIM59 | 0.774428 | 3 | 0 | 3 |
| RASA2 | SGSH | 0.773896 | 3 | 0 | 3 |
| RASA2 | IFT80 | 0.770873 | 3 | 0 | 3 |
| RASA2 | LRRC58 | 0.769457 | 3 | 0 | 3 |
| RASA2 | ERCC6 | 0.765137 | 3 | 0 | 3 |
| RASA2 | ATR | 0.758353 | 4 | 0 | 3 |
| RASA2 | GTF2A1 | 0.755481 | 4 | 0 | 4 |
| RASA2 | TULP4 | 0.754781 | 3 | 0 | 3 |
| RASA2 | WDR37 | 0.75135 | 3 | 0 | 3 |
| RASA2 | ATG2B | 0.745965 | 3 | 0 | 3 |
| RASA2 | SPCS2 | 0.744261 | 3 | 0 | 3 |
| RASA2 | RNPC3 | 0.740944 | 3 | 0 | 3 |
| RASA2 | AP1AR | 0.738415 | 3 | 0 | 3 |
| RASA2 | CCNJ | 0.730985 | 4 | 0 | 4 |
For details and further investigation, click here
