| Full name: oligosaccharyltransferase complex non-catalytic subunit | Alias Symbol: DC2 | ||
| Type: protein-coding gene | Cytoband: 4q25 | ||
| Entrez ID: 58505 | HGNC ID: HGNC:24448 | Ensembl Gene: ENSG00000198856 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of OSTC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | OSTC | 58505 | 223001_at | 0.2653 | 0.5841 | |
| GSE26886 | OSTC | 58505 | 223001_at | -0.9126 | 0.0017 | |
| GSE45670 | OSTC | 58505 | 223001_at | 0.0909 | 0.4353 | |
| GSE53622 | OSTC | 58505 | 7334 | 0.4898 | 0.0000 | |
| GSE53624 | OSTC | 58505 | 7334 | 0.3097 | 0.0001 | |
| GSE63941 | OSTC | 58505 | 223001_at | -0.6632 | 0.0198 | |
| GSE77861 | OSTC | 58505 | 223001_at | -0.3430 | 0.4243 | |
| GSE97050 | OSTC | 58505 | A_23_P411814 | 0.6150 | 0.1862 | |
| SRP007169 | OSTC | 58505 | RNAseq | -0.3601 | 0.3112 | |
| SRP008496 | OSTC | 58505 | RNAseq | -0.2361 | 0.2321 | |
| SRP064894 | OSTC | 58505 | RNAseq | 0.4520 | 0.0136 | |
| SRP133303 | OSTC | 58505 | RNAseq | 0.8851 | 0.0000 | |
| SRP159526 | OSTC | 58505 | RNAseq | 0.0992 | 0.6175 | |
| SRP193095 | OSTC | 58505 | RNAseq | -0.3781 | 0.0179 | |
| SRP219564 | OSTC | 58505 | RNAseq | 0.4996 | 0.0979 | |
| TCGA | OSTC | 58505 | RNAseq | 0.1007 | 0.0441 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by OSTC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of OSTC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | OSTC | 58505 | 0 | 12 | 18 | |
| GSE20123 | OSTC | 58505 | 0 | 12 | 18 | |
| GSE43470 | OSTC | 58505 | 0 | 13 | 30 | |
| GSE46452 | OSTC | 58505 | 1 | 36 | 22 | |
| GSE47630 | OSTC | 58505 | 0 | 20 | 20 | |
| GSE54993 | OSTC | 58505 | 9 | 0 | 61 | |
| GSE54994 | OSTC | 58505 | 1 | 10 | 42 | |
| GSE60625 | OSTC | 58505 | 0 | 3 | 8 | |
| GSE74703 | OSTC | 58505 | 0 | 11 | 25 | |
| GSE74704 | OSTC | 58505 | 0 | 6 | 14 | |
| TCGA | OSTC | 58505 | 8 | 35 | 53 |
Total number of gains: 19; Total number of losses: 158; Total Number of normals: 311.
Somatic mutations of OSTC:
Generating mutation plots.
Highly correlated genes for OSTC:
Showing top 20/408 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| OSTC | TSPAN5 | 0.791542 | 3 | 0 | 3 |
| OSTC | LY75 | 0.769386 | 3 | 0 | 3 |
| OSTC | DRAM2 | 0.76042 | 3 | 0 | 3 |
| OSTC | HM13 | 0.756258 | 3 | 0 | 3 |
| OSTC | RNASET2 | 0.748678 | 3 | 0 | 3 |
| OSTC | TMED9 | 0.748185 | 4 | 0 | 3 |
| OSTC | PSMA2 | 0.748088 | 3 | 0 | 3 |
| OSTC | PPP1R3D | 0.727409 | 3 | 0 | 3 |
| OSTC | CKAP4 | 0.725644 | 3 | 0 | 3 |
| OSTC | APEH | 0.71721 | 3 | 0 | 3 |
| OSTC | PPIP5K2 | 0.716759 | 4 | 0 | 4 |
| OSTC | HLA-DPB1 | 0.710231 | 3 | 0 | 3 |
| OSTC | SEC24D | 0.707147 | 7 | 0 | 7 |
| OSTC | ZYG11A | 0.707081 | 3 | 0 | 3 |
| OSTC | PDCD6 | 0.706797 | 3 | 0 | 3 |
| OSTC | ATP6V1B2 | 0.704643 | 4 | 0 | 4 |
| OSTC | ARNTL2 | 0.70267 | 3 | 0 | 3 |
| OSTC | IKZF3 | 0.699058 | 3 | 0 | 3 |
| OSTC | ATRN | 0.69904 | 3 | 0 | 3 |
| OSTC | TNFRSF19 | 0.697146 | 3 | 0 | 3 |
For details and further investigation, click here
