| Full name: protein phosphatase 1 regulatory subunit 3E | Alias Symbol: FLJ00089 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 90673 | HGNC ID: HGNC:14943 | Ensembl Gene: ENSG00000235194 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
PPP1R3E involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04910 | Insulin signaling pathway | |
| hsa04931 | Insulin resistance |
Expression of PPP1R3E:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PPP1R3E | 90673 | 229001_at | 0.2162 | 0.8107 | |
| GSE26886 | PPP1R3E | 90673 | 229001_at | -0.3919 | 0.0970 | |
| GSE45670 | PPP1R3E | 90673 | 229001_at | 0.1975 | 0.3308 | |
| GSE53622 | PPP1R3E | 90673 | 6552 | -0.0320 | 0.8062 | |
| GSE53624 | PPP1R3E | 90673 | 6552 | -0.1781 | 0.0495 | |
| GSE63941 | PPP1R3E | 90673 | 229001_at | 0.3598 | 0.5286 | |
| GSE77861 | PPP1R3E | 90673 | 229001_at | 0.2703 | 0.3835 | |
| SRP007169 | PPP1R3E | 90673 | RNAseq | 0.5907 | 0.2949 | |
| SRP064894 | PPP1R3E | 90673 | RNAseq | -0.0454 | 0.7950 | |
| SRP133303 | PPP1R3E | 90673 | RNAseq | -0.1328 | 0.4299 | |
| SRP159526 | PPP1R3E | 90673 | RNAseq | 0.0540 | 0.8184 | |
| SRP193095 | PPP1R3E | 90673 | RNAseq | 0.0642 | 0.6003 | |
| SRP219564 | PPP1R3E | 90673 | RNAseq | 0.3387 | 0.4594 | |
| TCGA | PPP1R3E | 90673 | RNAseq | -0.2259 | 0.0510 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PPP1R3E expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PPP1R3E:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PPP1R3E | 90673 | 9 | 1 | 20 | |
| GSE20123 | PPP1R3E | 90673 | 9 | 1 | 20 | |
| GSE43470 | PPP1R3E | 90673 | 7 | 2 | 34 | |
| GSE46452 | PPP1R3E | 90673 | 17 | 2 | 40 | |
| GSE47630 | PPP1R3E | 90673 | 11 | 10 | 19 | |
| GSE54993 | PPP1R3E | 90673 | 3 | 11 | 56 | |
| GSE54994 | PPP1R3E | 90673 | 18 | 5 | 30 | |
| GSE60625 | PPP1R3E | 90673 | 0 | 2 | 9 | |
| GSE74703 | PPP1R3E | 90673 | 6 | 2 | 28 | |
| GSE74704 | PPP1R3E | 90673 | 4 | 1 | 15 | |
| TCGA | PPP1R3E | 90673 | 27 | 14 | 55 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of PPP1R3E:
Generating mutation plots.
Highly correlated genes for PPP1R3E:
Showing all 17 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PPP1R3E | PABPN1 | 0.666425 | 5 | 0 | 5 |
| PPP1R3E | KHNYN | 0.663088 | 4 | 0 | 4 |
| PPP1R3E | PSME1 | 0.656497 | 3 | 0 | 3 |
| PPP1R3E | TM9SF1 | 0.653548 | 3 | 0 | 3 |
| PPP1R3E | AP1G2 | 0.618664 | 4 | 0 | 3 |
| PPP1R3E | OSGEP | 0.598316 | 4 | 0 | 3 |
| PPP1R3E | BRMS1L | 0.592866 | 3 | 0 | 3 |
| PPP1R3E | APEX1 | 0.592133 | 4 | 0 | 3 |
| PPP1R3E | EFS | 0.580982 | 5 | 0 | 3 |
| PPP1R3E | NGDN | 0.577264 | 4 | 0 | 4 |
| PPP1R3E | RBM23 | 0.569613 | 6 | 0 | 3 |
| PPP1R3E | THTPA | 0.569072 | 4 | 0 | 3 |
| PPP1R3E | GNGT1 | 0.565416 | 3 | 0 | 3 |
| PPP1R3E | CDK5RAP3 | 0.542573 | 6 | 0 | 4 |
| PPP1R3E | METTL17 | 0.541711 | 6 | 0 | 4 |
| PPP1R3E | NEK8 | 0.535601 | 4 | 0 | 3 |
| PPP1R3E | C14orf93 | 0.513957 | 5 | 0 | 3 |
For details and further investigation, click here
