APEX1

 

Full name: apurinic/apyrimidinic endodeoxyribonuclease 1 Alias Symbol: APE|REF1|HAP1|APX|APEN|REF-1|APE-1
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 328 HGNC ID: HGNC:587 Ensembl Gene: ENSG00000100823 OMIM ID: 107748
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of APEX1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 APEX1 328 210027_s_at 0.3774 0.2009
GSE20347 APEX1 328 210027_s_at 0.7947 0.0015
GSE23400 APEX1 328 210027_s_at 0.7860 0.0000
GSE26886 APEX1 328 210027_s_at 0.5664 0.0035
GSE29001 APEX1 328 210027_s_at 0.6496 0.1166
GSE38129 APEX1 328 210027_s_at 0.8113 0.0000
GSE45670 APEX1 328 210027_s_at 0.2848 0.1726
GSE53622 APEX1 328 91979 0.7171 0.0000
GSE53624 APEX1 328 91979 0.6891 0.0000
GSE63941 APEX1 328 210027_s_at 0.7950 0.1053
GSE77861 APEX1 328 210027_s_at 0.8042 0.0727
GSE97050 APEX1 328 A_23_P151653 0.5248 0.1204
SRP007169 APEX1 328 RNAseq 2.1463 0.0000
SRP008496 APEX1 328 RNAseq 2.0390 0.0000
SRP064894 APEX1 328 RNAseq 0.6615 0.0000
SRP133303 APEX1 328 RNAseq 0.3198 0.0657
SRP159526 APEX1 328 RNAseq 0.5360 0.0037
SRP193095 APEX1 328 RNAseq 0.2715 0.0681
SRP219564 APEX1 328 RNAseq 0.3510 0.1725
TCGA APEX1 328 RNAseq 0.1580 0.0007

Upregulated datasets: 2; Downregulated datasets: 0.  

 

Survival by APEX1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of APEX1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 APEX1 328 10 3 17
GSE20123 APEX1 328 8 3 19
GSE43470 APEX1 328 7 1 35
GSE46452 APEX1 328 19 2 38
GSE47630 APEX1 328 10 10 20
GSE54993 APEX1 328 3 11 56
GSE54994 APEX1 328 18 5 30
GSE60625 APEX1 328 0 2 9
GSE74703 APEX1 328 6 1 29
GSE74704 APEX1 328 4 2 14
TCGA APEX1 328 28 16 52

Total number of gains: 113; Total number of losses: 56; Total Number of normals: 319.  

 

Somatic mutations of APEX1:

 

Generating mutation plots.

 

Highly correlated genes for APEX1:

 

Showing top 20/1617 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
APEX1SUPT16H0.79470713013
APEX1TYW50.763166303
APEX1NGDN0.74775513012
APEX1NOP560.735827303
APEX1CCNB1IP10.73398113010
APEX1PARP20.73157713012
APEX1NUDCD10.728143606
APEX1METTL30.72791912011
APEX1SPIC0.727179303
APEX1PYCR20.725707303
APEX1CCT40.72016610010
APEX1ATP6V1C10.71464211011
APEX1ILF20.71149712010
APEX1RAB340.711296303
APEX1EMG10.709362807
APEX1CHD70.702111303
APEX1BOD10.701651606
APEX1SNAP470.700517303
APEX1MAD2L20.699523404
APEX1EBNA1BP20.699189303

For details and further investigation, click here