NGDN

 

Full name: neuroguidin Alias Symbol: DKFZP564O092|LCP5|lpd-2|NGD|CANu1
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 25983 HGNC ID: HGNC:20271 Ensembl Gene: ENSG00000129460 OMIM ID: 610777
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of NGDN:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 NGDN 25983 213794_s_at 0.4731 0.5217
GSE20347 NGDN 25983 213794_s_at 0.6605 0.0007
GSE23400 NGDN 25983 213794_s_at 0.5903 0.0000
GSE26886 NGDN 25983 213794_s_at 0.5400 0.0022
GSE29001 NGDN 25983 213794_s_at 0.6574 0.0141
GSE38129 NGDN 25983 213794_s_at 0.5025 0.0002
GSE45670 NGDN 25983 213794_s_at 0.4448 0.0332
GSE53622 NGDN 25983 112701 0.3628 0.0000
GSE53624 NGDN 25983 112701 0.4878 0.0000
GSE63941 NGDN 25983 213794_s_at 1.0799 0.0279
GSE77861 NGDN 25983 213794_s_at 0.6866 0.0516
GSE97050 NGDN 25983 A_23_P76841 0.2353 0.3837
SRP007169 NGDN 25983 RNAseq 1.6211 0.0029
SRP008496 NGDN 25983 RNAseq 1.2015 0.0048
SRP064894 NGDN 25983 RNAseq 0.5857 0.0006
SRP133303 NGDN 25983 RNAseq 0.6712 0.0046
SRP159526 NGDN 25983 RNAseq 0.4349 0.0276
SRP193095 NGDN 25983 RNAseq 0.4101 0.0078
SRP219564 NGDN 25983 RNAseq 0.6143 0.0979
TCGA NGDN 25983 RNAseq 0.2402 0.0001

Upregulated datasets: 3; Downregulated datasets: 0.  

 

Survival by NGDN expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of NGDN:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 NGDN 25983 8 1 21
GSE20123 NGDN 25983 8 1 21
GSE43470 NGDN 25983 7 2 34
GSE46452 NGDN 25983 17 2 40
GSE47630 NGDN 25983 11 10 19
GSE54993 NGDN 25983 3 11 56
GSE54994 NGDN 25983 18 5 30
GSE60625 NGDN 25983 0 2 9
GSE74703 NGDN 25983 6 2 28
GSE74704 NGDN 25983 3 1 16
TCGA NGDN 25983 27 14 55

Total number of gains: 108; Total number of losses: 51; Total Number of normals: 329.  

 

Somatic mutations of NGDN:

 

Generating mutation plots.

 

Highly correlated genes for NGDN:

 

Showing top 20/1094 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
NGDNSUPT16H0.76815513013
NGDNAPEX10.74775513012
NGDNPARP20.72477113012
NGDNCCNB1IP10.7058412012
NGDNMETTL30.69058113013
NGDNMNAT10.68589213012
NGDNPET1170.685055303
NGDNMETTL170.68285511010
NGDNNEDD80.679711010
NGDNC14orf1190.67805504
NGDNGMPR20.67410812011
NGDNRLIM0.673232303
NGDNPPT10.6722871009
NGDNAHSA10.66814412010
NGDNATP6V1C10.66810810010
NGDNPGM2L10.667752505
NGDNMRPL90.667233808
NGDNDUSP230.665028303
NGDNRUVBL10.6620611010
NGDNADSL0.65864311010

For details and further investigation, click here