GNGT1

 

Full name: G protein subunit gamma transducin 1 Alias Symbol: GNG1
Type: protein-coding gene Cytoband: 7q21.3
Entrez ID: 2792 HGNC ID: HGNC:4411 Ensembl Gene: ENSG00000127928 OMIM ID: 189970
Drug and gene relationship at DGIdb

 

GNGT1 involved pathways:

KEGG pathway Description View
hsa04014Ras signaling pathway
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04713Circadian entrainment
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa05032Morphine addiction
hsa05034Alcoholism

 

Expression of GNGT1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 GNGT1 2792 207166_at 0.7058 0.1218
GSE20347 GNGT1 2792 207166_at 0.3394 0.0001
GSE23400 GNGT1 2792 207166_at 0.0349 0.0610
GSE26886 GNGT1 2792 207166_at 1.5976 0.0001
GSE29001 GNGT1 2792 207166_at 1.0876 0.0005
GSE38129 GNGT1 2792 207166_at 0.5124 0.0000
GSE45670 GNGT1 2792 207166_at 0.4829 0.0292
GSE53622 GNGT1 2792 99647 0.6601 0.0000
GSE53624 GNGT1 2792 102873 3.4853 0.0000
GSE63941 GNGT1 2792 207166_at 0.4339 0.3722
GSE77861 GNGT1 2792 207166_at -0.0156 0.8639
TCGA GNGT1 2792 RNAseq 3.8863 0.0000

Upregulated datasets: 4; Downregulated datasets: 0.  

 

Survival by GNGT1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of GNGT1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 GNGT1 2792 13 0 17
GSE20123 GNGT1 2792 13 0 17
GSE43470 GNGT1 2792 7 1 35
GSE46452 GNGT1 2792 12 0 47
GSE47630 GNGT1 2792 9 2 29
GSE54993 GNGT1 2792 1 9 60
GSE54994 GNGT1 2792 16 2 35
GSE60625 GNGT1 2792 0 5 6
GSE74703 GNGT1 2792 6 1 29
GSE74704 GNGT1 2792 9 0 11
TCGA GNGT1 2792 56 4 36

Total number of gains: 142; Total number of losses: 24; Total Number of normals: 322.  

 

Somatic mutations of GNGT1:

 

Generating mutation plots.

 

Highly correlated genes for GNGT1:

 

Showing top 20/440 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
GNGT1SPATC1L0.721111303
GNGT1SLC45A40.703135303
GNGT1PGM2L10.690391303
GNGT1SDR39U10.686365303
GNGT1FXR10.685963505
GNGT1U2SURP0.669331605
GNGT1DNAJB110.666414303
GNGT1LINC010040.661613303
GNGT1KPNB10.6552303
GNGT1XCL10.647992908
GNGT1IMMP1L0.646666403
GNGT1HOXC100.644359807
GNGT1TRAF50.640143303
GNGT1HHIPL20.637721403
GNGT1STMN10.63682706
GNGT1ZNF6800.635888303
GNGT1ADH50.635788303
GNGT1HOXD110.634719907
GNGT1RAG10.634271505
GNGT1PLXNA10.630736807

For details and further investigation, click here