METTL17

 

Full name: methyltransferase like 17 Alias Symbol: FLJ20859
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 64745 HGNC ID: HGNC:19280 Ensembl Gene: ENSG00000165792 OMIM ID: 616091
Drug and gene relationship at DGIdb
Screen Evidence:

 

Expression of METTL17:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 METTL17 64745 223988_x_at 0.2368 0.5935
GSE20347 METTL17 64745 218366_x_at 0.4149 0.0331
GSE23400 METTL17 64745 218366_x_at 0.4452 0.0000
GSE26886 METTL17 64745 223988_x_at -0.0933 0.6155
GSE29001 METTL17 64745 218366_x_at 0.4974 0.1697
GSE38129 METTL17 64745 218366_x_at 0.4182 0.0042
GSE45670 METTL17 64745 223988_x_at 0.3184 0.0120
GSE53622 METTL17 64745 16560 0.4536 0.0000
GSE53624 METTL17 64745 16560 0.4256 0.0000
GSE63941 METTL17 64745 218366_x_at 1.1701 0.0102
GSE77861 METTL17 64745 223988_x_at 0.2980 0.4101
GSE97050 METTL17 64745 A_23_P205529 0.1147 0.6184
SRP007169 METTL17 64745 RNAseq 0.1851 0.6217
SRP008496 METTL17 64745 RNAseq -0.0151 0.9523
SRP064894 METTL17 64745 RNAseq 0.4729 0.0032
SRP133303 METTL17 64745 RNAseq -0.0068 0.9646
SRP159526 METTL17 64745 RNAseq 0.2091 0.3381
SRP193095 METTL17 64745 RNAseq 0.0777 0.3973
SRP219564 METTL17 64745 RNAseq 0.3563 0.2985

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by METTL17 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of METTL17:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 METTL17 64745 9 3 18
GSE20123 METTL17 64745 8 3 19
GSE43470 METTL17 64745 7 1 35
GSE46452 METTL17 64745 19 2 38
GSE47630 METTL17 64745 10 10 20
GSE54993 METTL17 64745 3 11 56
GSE54994 METTL17 64745 18 5 30
GSE60625 METTL17 64745 0 2 9
GSE74703 METTL17 64745 6 1 29
GSE74704 METTL17 64745 4 2 14
TCGA METTL17 64745 27 16 53

Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.  

 

Somatic mutations of METTL17:

 

Generating mutation plots.

 

Highly correlated genes for METTL17:

 

Showing top 20/678 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
METTL17SNRNP2000.769544303
METTL17CHURC10.752739404
METTL17SUPT16H0.7498612012
METTL17OXA1L0.745751009
METTL17TOX40.744569606
METTL17METTL30.73949412011
METTL17DEPDC50.730144303
METTL17C2orf690.72225303
METTL17PARP20.7212551109
METTL17RNF1450.720358303
METTL17SYK0.711253303
METTL17RLIM0.7057403
METTL17PSTPIP20.705217303
METTL17CHD80.703811010
METTL17CDCA70.702812404
METTL17MAP3K130.699212303
METTL17APEX10.69559411010
METTL17ZNF2760.693629303
METTL17ARFRP10.691382303
METTL17NEK80.691378303

For details and further investigation, click here