| Full name: proteasome activator subunit 1 | Alias Symbol: IFI5111|PA28alpha | ||
| Type: protein-coding gene | Cytoband: 14q12 | ||
| Entrez ID: 5720 | HGNC ID: HGNC:9568 | Ensembl Gene: ENSG00000092010 | OMIM ID: 600654 |
| Drug and gene relationship at DGIdb | |||
PSME1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04612 | Antigen processing and presentation |
Expression of PSME1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSME1 | 5720 | 200814_at | 0.1705 | 0.7496 | |
| GSE20347 | PSME1 | 5720 | 200814_at | 0.0277 | 0.8693 | |
| GSE23400 | PSME1 | 5720 | 200814_at | 0.2516 | 0.0008 | |
| GSE26886 | PSME1 | 5720 | 200814_at | 0.4434 | 0.0502 | |
| GSE29001 | PSME1 | 5720 | 200814_at | 0.2018 | 0.3402 | |
| GSE38129 | PSME1 | 5720 | 200814_at | 0.0379 | 0.7431 | |
| GSE45670 | PSME1 | 5720 | 200814_at | 0.2630 | 0.1425 | |
| GSE53622 | PSME1 | 5720 | 79933 | 0.1472 | 0.0899 | |
| GSE53624 | PSME1 | 5720 | 79933 | 0.0545 | 0.5613 | |
| GSE63941 | PSME1 | 5720 | 200814_at | 0.9241 | 0.1269 | |
| GSE77861 | PSME1 | 5720 | 200814_at | 0.0394 | 0.8976 | |
| GSE97050 | PSME1 | 5720 | A_23_P151614 | 0.6342 | 0.0908 | |
| SRP007169 | PSME1 | 5720 | RNAseq | 0.3311 | 0.4287 | |
| SRP008496 | PSME1 | 5720 | RNAseq | 0.0054 | 0.9857 | |
| SRP064894 | PSME1 | 5720 | RNAseq | 0.4081 | 0.0528 | |
| SRP133303 | PSME1 | 5720 | RNAseq | 0.3845 | 0.0447 | |
| SRP159526 | PSME1 | 5720 | RNAseq | 0.1836 | 0.6059 | |
| SRP193095 | PSME1 | 5720 | RNAseq | -0.0154 | 0.9089 | |
| SRP219564 | PSME1 | 5720 | RNAseq | 0.5468 | 0.0611 | |
| TCGA | PSME1 | 5720 | RNAseq | 0.1556 | 0.0036 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PSME1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSME1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSME1 | 5720 | 8 | 3 | 19 | |
| GSE20123 | PSME1 | 5720 | 8 | 3 | 19 | |
| GSE43470 | PSME1 | 5720 | 8 | 2 | 33 | |
| GSE46452 | PSME1 | 5720 | 16 | 2 | 41 | |
| GSE47630 | PSME1 | 5720 | 11 | 10 | 19 | |
| GSE54993 | PSME1 | 5720 | 3 | 11 | 56 | |
| GSE54994 | PSME1 | 5720 | 18 | 5 | 30 | |
| GSE60625 | PSME1 | 5720 | 0 | 2 | 9 | |
| GSE74703 | PSME1 | 5720 | 7 | 2 | 27 | |
| GSE74704 | PSME1 | 5720 | 3 | 2 | 15 | |
| TCGA | PSME1 | 5720 | 27 | 13 | 56 |
Total number of gains: 109; Total number of losses: 55; Total Number of normals: 324.
Somatic mutations of PSME1:
Generating mutation plots.
Highly correlated genes for PSME1:
Showing top 20/442 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSME1 | PSME2 | 0.795471 | 3 | 0 | 3 |
| PSME1 | HDAC2 | 0.732656 | 3 | 0 | 3 |
| PSME1 | LAMB1 | 0.731904 | 3 | 0 | 3 |
| PSME1 | TOP1MT | 0.729031 | 3 | 0 | 3 |
| PSME1 | CD36 | 0.72348 | 3 | 0 | 3 |
| PSME1 | ST3GAL5 | 0.717265 | 3 | 0 | 3 |
| PSME1 | PRDX3 | 0.713645 | 4 | 0 | 3 |
| PSME1 | RPE | 0.708983 | 3 | 0 | 3 |
| PSME1 | HAUS4 | 0.70887 | 4 | 0 | 3 |
| PSME1 | SLC2A4RG | 0.707347 | 3 | 0 | 3 |
| PSME1 | SLC25A24 | 0.70682 | 3 | 0 | 3 |
| PSME1 | LRRC39 | 0.705482 | 3 | 0 | 3 |
| PSME1 | SEMA3C | 0.70016 | 3 | 0 | 3 |
| PSME1 | TSEN15 | 0.699711 | 3 | 0 | 3 |
| PSME1 | NAPG | 0.698086 | 3 | 0 | 3 |
| PSME1 | VAPA | 0.691476 | 3 | 0 | 3 |
| PSME1 | ANKZF1 | 0.687842 | 3 | 0 | 3 |
| PSME1 | MYO1G | 0.686502 | 3 | 0 | 3 |
| PSME1 | C11orf74 | 0.685542 | 3 | 0 | 3 |
| PSME1 | TSPAN9 | 0.684024 | 4 | 0 | 4 |
For details and further investigation, click here
