PABPN1

 

Full name: poly(A) binding protein nuclear 1 Alias Symbol: PAB2
Type: protein-coding gene Cytoband: 14q11.2
Entrez ID: 8106 HGNC ID: HGNC:8565 Ensembl Gene: ENSG00000100836 OMIM ID: 602279
Drug and gene relationship at DGIdb

 

Expression of PABPN1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PABPN1 8106 213046_at 0.1088 0.9272
GSE20347 PABPN1 8106 213046_at 0.3282 0.1685
GSE23400 PABPN1 8106 213046_at 0.2002 0.0008
GSE26886 PABPN1 8106 213046_at -0.5543 0.0075
GSE29001 PABPN1 8106 213046_at 0.2558 0.2799
GSE38129 PABPN1 8106 213046_at 0.2374 0.2375
GSE45670 PABPN1 8106 213046_at 0.2651 0.2400
GSE63941 PABPN1 8106 213046_at -0.1977 0.7831
GSE77861 PABPN1 8106 213046_at 0.4910 0.0692
GSE97050 PABPN1 8106 A_23_P128828 0.5301 0.0950
SRP007169 PABPN1 8106 RNAseq 0.3200 0.4131
SRP008496 PABPN1 8106 RNAseq 0.2535 0.3091
SRP064894 PABPN1 8106 RNAseq 0.4449 0.0063
SRP133303 PABPN1 8106 RNAseq 0.2828 0.0552
SRP159526 PABPN1 8106 RNAseq 0.4263 0.1023
SRP193095 PABPN1 8106 RNAseq 0.1190 0.2144
SRP219564 PABPN1 8106 RNAseq 0.4070 0.3565
TCGA PABPN1 8106 RNAseq 0.1042 0.0207

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PABPN1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of PABPN1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PABPN1 8106 9 1 20
GSE20123 PABPN1 8106 9 1 20
GSE43470 PABPN1 8106 7 2 34
GSE46452 PABPN1 8106 17 2 40
GSE47630 PABPN1 8106 11 10 19
GSE54993 PABPN1 8106 3 11 56
GSE54994 PABPN1 8106 18 5 30
GSE60625 PABPN1 8106 0 2 9
GSE74703 PABPN1 8106 6 2 28
GSE74704 PABPN1 8106 4 1 15
TCGA PABPN1 8106 27 14 55

Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.  

 

Somatic mutations of PABPN1:

 

Generating mutation plots.

 

Highly correlated genes for PABPN1:

 

Showing top 20/122 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PABPN1FUCA20.70196303
PABPN1RPF20.692912303
PABPN1RAB2B0.686144403
PABPN1PPP1R3E0.666425505
PABPN1CLN80.661802303
PABPN1METTL30.661632707
PABPN1NDRG10.659214303
PABPN1PPP6R20.652941504
PABPN1ACIN10.649491009
PABPN1HSPBP10.618973303
PABPN1AP1G20.616359907
PABPN1PTP4A10.615466403
PABPN1ANKZF10.602933604
PABPN1SRP540.602802503
PABPN1QKI0.602362303
PABPN1ZNF7130.602165403
PABPN1CHD80.600919906
PABPN1SNORA210.598234606
PABPN1PRR14L0.597645403
PABPN1ANKRD360.59712303

For details and further investigation, click here