| Full name: actin related protein 2/3 complex subunit 2 | Alias Symbol: p34-Arc|ARC34 | ||
| Type: protein-coding gene | Cytoband: 2q35 | ||
| Entrez ID: 10109 | HGNC ID: HGNC:705 | Ensembl Gene: ENSG00000163466 | OMIM ID: 604224 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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ARPC2 involved pathways:
Expression of ARPC2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ARPC2 | 10109 | 208679_s_at | -0.4386 | 0.3446 | |
| GSE20347 | ARPC2 | 10109 | 208679_s_at | -1.0830 | 0.0000 | |
| GSE23400 | ARPC2 | 10109 | 208679_s_at | -0.4628 | 0.0000 | |
| GSE26886 | ARPC2 | 10109 | 213513_x_at | -0.9394 | 0.0000 | |
| GSE29001 | ARPC2 | 10109 | 207988_s_at | -0.5753 | 0.0071 | |
| GSE38129 | ARPC2 | 10109 | 208679_s_at | -0.6679 | 0.0000 | |
| GSE45670 | ARPC2 | 10109 | 208679_s_at | -0.3305 | 0.0071 | |
| GSE53622 | ARPC2 | 10109 | 78758 | -0.5361 | 0.0000 | |
| GSE53624 | ARPC2 | 10109 | 78758 | -0.4809 | 0.0000 | |
| GSE63941 | ARPC2 | 10109 | 208679_s_at | 0.3326 | 0.3007 | |
| GSE77861 | ARPC2 | 10109 | 208679_s_at | -0.5890 | 0.0164 | |
| GSE97050 | ARPC2 | 10109 | A_23_P102122 | -0.0105 | 0.9816 | |
| SRP007169 | ARPC2 | 10109 | RNAseq | -1.8075 | 0.0000 | |
| SRP008496 | ARPC2 | 10109 | RNAseq | -1.6378 | 0.0000 | |
| SRP064894 | ARPC2 | 10109 | RNAseq | -0.6787 | 0.0000 | |
| SRP133303 | ARPC2 | 10109 | RNAseq | -0.5112 | 0.0019 | |
| SRP159526 | ARPC2 | 10109 | RNAseq | -1.0032 | 0.0000 | |
| SRP193095 | ARPC2 | 10109 | RNAseq | -1.1789 | 0.0000 | |
| SRP219564 | ARPC2 | 10109 | RNAseq | -1.0133 | 0.0141 | |
| TCGA | ARPC2 | 10109 | RNAseq | 0.0774 | 0.0638 |
Upregulated datasets: 0; Downregulated datasets: 6.
Survival by ARPC2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ARPC2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ARPC2 | 10109 | 1 | 14 | 15 | |
| GSE20123 | ARPC2 | 10109 | 1 | 13 | 16 | |
| GSE43470 | ARPC2 | 10109 | 1 | 7 | 35 | |
| GSE46452 | ARPC2 | 10109 | 0 | 5 | 54 | |
| GSE47630 | ARPC2 | 10109 | 4 | 5 | 31 | |
| GSE54993 | ARPC2 | 10109 | 1 | 2 | 67 | |
| GSE54994 | ARPC2 | 10109 | 8 | 10 | 35 | |
| GSE60625 | ARPC2 | 10109 | 0 | 3 | 8 | |
| GSE74703 | ARPC2 | 10109 | 1 | 5 | 30 | |
| GSE74704 | ARPC2 | 10109 | 1 | 7 | 12 | |
| TCGA | ARPC2 | 10109 | 11 | 27 | 58 |
Total number of gains: 29; Total number of losses: 98; Total Number of normals: 361.
Somatic mutations of ARPC2:
Generating mutation plots.
Highly correlated genes for ARPC2:
Showing top 20/1680 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ARPC2 | CUL3 | 0.772115 | 10 | 0 | 10 |
| ARPC2 | NAGK | 0.762132 | 11 | 0 | 10 |
| ARPC2 | FAM170A | 0.759524 | 3 | 0 | 3 |
| ARPC2 | PDLIM2 | 0.758821 | 9 | 0 | 9 |
| ARPC2 | S100A16 | 0.757139 | 6 | 0 | 6 |
| ARPC2 | CCNYL1 | 0.755695 | 5 | 0 | 4 |
| ARPC2 | BNIPL | 0.753529 | 6 | 0 | 6 |
| ARPC2 | ORMDL2 | 0.752698 | 8 | 0 | 8 |
| ARPC2 | CCDC25 | 0.751301 | 3 | 0 | 3 |
| ARPC2 | A2ML1 | 0.74821 | 6 | 0 | 6 |
| ARPC2 | PPP1R7 | 0.747141 | 10 | 0 | 10 |
| ARPC2 | SH3GLB1 | 0.744662 | 10 | 0 | 10 |
| ARPC2 | IKZF5 | 0.742851 | 3 | 0 | 3 |
| ARPC2 | ZFAND2B | 0.740208 | 8 | 0 | 8 |
| ARPC2 | SFTA2 | 0.7391 | 4 | 0 | 4 |
| ARPC2 | CLIC3 | 0.737999 | 8 | 0 | 8 |
| ARPC2 | VPS4B | 0.737454 | 11 | 0 | 11 |
| ARPC2 | GRN | 0.736241 | 9 | 0 | 9 |
| ARPC2 | CYSRT1 | 0.733832 | 6 | 0 | 6 |
| ARPC2 | MPP7 | 0.733619 | 7 | 0 | 7 |
For details and further investigation, click here
