PPP2R1A

 

Full name: protein phosphatase 2 scaffold subunit Aalpha Alias Symbol: PR65A|PP2A-Aalpha|PP2AA
Type: protein-coding gene Cytoband: 19q13.41
Entrez ID: 5518 HGNC ID: HGNC:9302 Ensembl Gene: ENSG00000105568 OMIM ID: 605983
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 237/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

PPP2R1A involved pathways:

KEGG pathway Description View
hsa04071Sphingolipid signaling pathway
hsa04114Oocyte meiosis
hsa04151PI3K-Akt signaling pathway
hsa04261Adrenergic signaling in cardiomyocytes
hsa04350TGF-beta signaling pathway
hsa04390Hippo signaling pathway
hsa04530Tight junction
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa05142Chagas disease (American trypanosomiasis)
hsa05160Hepatitis C

 

Expression of PPP2R1A:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PPP2R1A 5518 200695_at -0.1077 0.7346
GSE20347 PPP2R1A 5518 200695_at -0.6446 0.0002
GSE23400 PPP2R1A 5518 200695_at -0.4136 0.0000
GSE26886 PPP2R1A 5518 200695_at -1.1897 0.0010
GSE29001 PPP2R1A 5518 200695_at -0.7313 0.0021
GSE38129 PPP2R1A 5518 200695_at -0.4027 0.0012
GSE45670 PPP2R1A 5518 200695_at -0.0487 0.7780
GSE53622 PPP2R1A 5518 75241 -0.5875 0.0000
GSE53624 PPP2R1A 5518 10961 -0.3109 0.0000
GSE63941 PPP2R1A 5518 200695_at 2.1936 0.0000
GSE77861 PPP2R1A 5518 200695_at -0.3163 0.1742
GSE97050 PPP2R1A 5518 A_23_P107661 -0.3011 0.2185
SRP007169 PPP2R1A 5518 RNAseq -1.4928 0.0000
SRP008496 PPP2R1A 5518 RNAseq -1.4037 0.0000
SRP064894 PPP2R1A 5518 RNAseq -0.2032 0.3829
SRP133303 PPP2R1A 5518 RNAseq -0.3453 0.0496
SRP159526 PPP2R1A 5518 RNAseq -0.2568 0.3328
SRP193095 PPP2R1A 5518 RNAseq -0.3905 0.0004
SRP219564 PPP2R1A 5518 RNAseq -0.3654 0.2342
TCGA PPP2R1A 5518 RNAseq -0.0034 0.9324

Upregulated datasets: 1; Downregulated datasets: 3.  

 

Survival by PPP2R1A expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PPP2R1A:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PPP2R1A 5518 3 5 22
GSE20123 PPP2R1A 5518 3 4 23
GSE43470 PPP2R1A 5518 3 11 29
GSE46452 PPP2R1A 5518 45 1 13
GSE47630 PPP2R1A 5518 9 6 25
GSE54993 PPP2R1A 5518 17 4 49
GSE54994 PPP2R1A 5518 4 14 35
GSE60625 PPP2R1A 5518 9 0 2
GSE74703 PPP2R1A 5518 3 7 26
GSE74704 PPP2R1A 5518 3 2 15
TCGA PPP2R1A 5518 15 20 61

Total number of gains: 114; Total number of losses: 74; Total Number of normals: 300.  

 

Somatic mutations of PPP2R1A:

 

Generating mutation plots.

 

Highly correlated genes for PPP2R1A:

 

Showing top 20/876 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PPP2R1AMPV17L0.819018303
PPP2R1APOLN0.777327303
PPP2R1AZNF2070.769235303
PPP2R1AZNF6830.75325303
PPP2R1ASLC25A10.749145303
PPP2R1ANAPA0.74108712011
PPP2R1ARAB4B0.740467404
PPP2R1ABTBD20.73711303
PPP2R1APRKCSH0.736455303
PPP2R1ARBP20.73313303
PPP2R1AMBOAT10.72859303
PPP2R1ARAB40AL0.727457303
PPP2R1ASLC25A390.724005505
PPP2R1ASIK10.723608303
PPP2R1AADM50.723035303
PPP2R1ADHDH0.720374303
PPP2R1AKLHDC30.719956403
PPP2R1AFLYWCH20.71806303
PPP2R1AMAP1LC3A0.711817303
PPP2R1ASYNGR20.709117404

For details and further investigation, click here