| Full name: microtubule associated protein 1 light chain 3 alpha | Alias Symbol: MAP1BLC3|MAP1ALC3|LC3|LC3A|ATG8E | ||
| Type: protein-coding gene | Cytoband: 20q11.22 | ||
| Entrez ID: 84557 | HGNC ID: HGNC:6838 | Ensembl Gene: ENSG00000101460 | OMIM ID: 601242 |
| Drug and gene relationship at DGIdb | |||
Expression of MAP1LC3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MAP1LC3A | 84557 | 224378_x_at | -0.2856 | 0.7140 | |
| GSE26886 | MAP1LC3A | 84557 | 224378_x_at | 0.0968 | 0.6609 | |
| GSE45670 | MAP1LC3A | 84557 | 224378_x_at | -0.2510 | 0.2179 | |
| GSE53622 | MAP1LC3A | 84557 | 5057 | -0.9062 | 0.0000 | |
| GSE53624 | MAP1LC3A | 84557 | 5057 | -0.6309 | 0.0000 | |
| GSE63941 | MAP1LC3A | 84557 | 224378_x_at | -0.6367 | 0.3655 | |
| GSE77861 | MAP1LC3A | 84557 | 227219_x_at | 0.2143 | 0.2442 | |
| GSE97050 | MAP1LC3A | 84557 | A_33_P3300308 | -0.5266 | 0.2151 | |
| SRP007169 | MAP1LC3A | 84557 | RNAseq | -2.4372 | 0.0000 | |
| SRP008496 | MAP1LC3A | 84557 | RNAseq | -2.1404 | 0.0000 | |
| SRP064894 | MAP1LC3A | 84557 | RNAseq | -0.8324 | 0.0462 | |
| SRP133303 | MAP1LC3A | 84557 | RNAseq | -0.8046 | 0.0086 | |
| SRP159526 | MAP1LC3A | 84557 | RNAseq | -0.7921 | 0.1187 | |
| SRP193095 | MAP1LC3A | 84557 | RNAseq | -0.8595 | 0.0002 | |
| SRP219564 | MAP1LC3A | 84557 | RNAseq | -1.0821 | 0.1092 | |
| TCGA | MAP1LC3A | 84557 | RNAseq | -0.3551 | 0.0059 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MAP1LC3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MAP1LC3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MAP1LC3A | 84557 | 16 | 0 | 14 | |
| GSE20123 | MAP1LC3A | 84557 | 16 | 0 | 14 | |
| GSE43470 | MAP1LC3A | 84557 | 12 | 0 | 31 | |
| GSE46452 | MAP1LC3A | 84557 | 29 | 0 | 30 | |
| GSE47630 | MAP1LC3A | 84557 | 24 | 1 | 15 | |
| GSE54993 | MAP1LC3A | 84557 | 0 | 18 | 52 | |
| GSE54994 | MAP1LC3A | 84557 | 25 | 1 | 27 | |
| GSE60625 | MAP1LC3A | 84557 | 0 | 0 | 11 | |
| GSE74703 | MAP1LC3A | 84557 | 11 | 0 | 25 | |
| GSE74704 | MAP1LC3A | 84557 | 11 | 0 | 9 | |
| TCGA | MAP1LC3A | 84557 | 50 | 2 | 44 |
Total number of gains: 194; Total number of losses: 22; Total Number of normals: 272.
Somatic mutations of MAP1LC3A:
Generating mutation plots.
Highly correlated genes for MAP1LC3A:
Showing top 20/377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MAP1LC3A | MMRN2 | 0.791999 | 3 | 0 | 3 |
| MAP1LC3A | ZBTB16 | 0.765959 | 3 | 0 | 3 |
| MAP1LC3A | FHL1 | 0.760835 | 3 | 0 | 3 |
| MAP1LC3A | MSRB3 | 0.753803 | 3 | 0 | 3 |
| MAP1LC3A | SNTB1 | 0.751406 | 3 | 0 | 3 |
| MAP1LC3A | ITGA9 | 0.746236 | 3 | 0 | 3 |
| MAP1LC3A | JAM3 | 0.744718 | 3 | 0 | 3 |
| MAP1LC3A | RNF214 | 0.741516 | 3 | 0 | 3 |
| MAP1LC3A | PDLIM3 | 0.740159 | 3 | 0 | 3 |
| MAP1LC3A | NKX6-1 | 0.73404 | 3 | 0 | 3 |
| MAP1LC3A | KANK2 | 0.733468 | 3 | 0 | 3 |
| MAP1LC3A | CNR1 | 0.733401 | 3 | 0 | 3 |
| MAP1LC3A | CELF2 | 0.729836 | 3 | 0 | 3 |
| MAP1LC3A | EDNRB | 0.728881 | 3 | 0 | 3 |
| MAP1LC3A | CASQ2 | 0.725554 | 3 | 0 | 3 |
| MAP1LC3A | SELENBP1 | 0.722249 | 3 | 0 | 3 |
| MAP1LC3A | ARL6IP4 | 0.721863 | 3 | 0 | 3 |
| MAP1LC3A | MYLK | 0.721041 | 3 | 0 | 3 |
| MAP1LC3A | CYSLTR1 | 0.720229 | 3 | 0 | 3 |
| MAP1LC3A | SGCE | 0.72007 | 3 | 0 | 3 |
For details and further investigation, click here
