SYNGR2

 

Full name: synaptogyrin 2 Alias Symbol: 
Type: protein-coding gene Cytoband: 17q25.3
Entrez ID: 9144 HGNC ID: HGNC:11499 Ensembl Gene: ENSG00000108639 OMIM ID: 603926
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of SYNGR2:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SYNGR2 9144 201079_at 0.2568 0.6692
GSE20347 SYNGR2 9144 201079_at -0.0783 0.5355
GSE23400 SYNGR2 9144 201079_at 0.2636 0.0039
GSE26886 SYNGR2 9144 201079_at -0.4118 0.0336
GSE29001 SYNGR2 9144 201079_at 0.1626 0.6940
GSE38129 SYNGR2 9144 201079_at 0.1515 0.2775
GSE45670 SYNGR2 9144 201079_at 0.2252 0.2688
GSE53622 SYNGR2 9144 26719 0.0364 0.6757
GSE53624 SYNGR2 9144 26719 0.0979 0.1297
GSE63941 SYNGR2 9144 201079_at 2.4439 0.0000
GSE77861 SYNGR2 9144 201079_at 0.4307 0.2799
GSE97050 SYNGR2 9144 A_24_P366526 0.1421 0.5697
SRP007169 SYNGR2 9144 RNAseq 0.1765 0.5786
SRP008496 SYNGR2 9144 RNAseq -0.0074 0.9726
SRP064894 SYNGR2 9144 RNAseq 0.3605 0.2082
SRP133303 SYNGR2 9144 RNAseq 0.4115 0.0028
SRP159526 SYNGR2 9144 RNAseq 0.3826 0.2785
SRP193095 SYNGR2 9144 RNAseq 0.1493 0.3144
SRP219564 SYNGR2 9144 RNAseq 0.1515 0.7135
TCGA SYNGR2 9144 RNAseq 0.0619 0.2757

Upregulated datasets: 1; Downregulated datasets: 0.  

 

Survival by SYNGR2 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of SYNGR2:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SYNGR2 9144 5 4 21
GSE20123 SYNGR2 9144 5 4 21
GSE43470 SYNGR2 9144 3 4 36
GSE46452 SYNGR2 9144 33 0 26
GSE47630 SYNGR2 9144 8 1 31
GSE54993 SYNGR2 9144 2 5 63
GSE54994 SYNGR2 9144 10 4 39
GSE60625 SYNGR2 9144 6 0 5
GSE74703 SYNGR2 9144 3 2 31
GSE74704 SYNGR2 9144 4 3 13
TCGA SYNGR2 9144 31 8 57

Total number of gains: 110; Total number of losses: 35; Total Number of normals: 343.  

 

Somatic mutations of SYNGR2:

 

Generating mutation plots.

 

Highly correlated genes for SYNGR2:

 

Showing top 20/548 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SYNGR2TUBGCP40.753131303
SYNGR2EEFSEC0.751278404
SYNGR2ZNF3840.734134404
SYNGR2POLA10.728095303
SYNGR2MUTYH0.724138303
SYNGR2SPRYD40.719275403
SYNGR2SRP680.716456404
SYNGR2ERI30.71419404
SYNGR2SEMA4A0.713955303
SYNGR2NUCB10.711535404
SYNGR2GNAI20.709702404
SYNGR2PPP2R1A0.709117404
SYNGR2ETV60.704422303
SYNGR2COPZ10.700882505
SYNGR2RPL80.696056606
SYNGR2MPV17L0.694489303
SYNGR2WBP110.691047403
SYNGR2RNF2200.689914504
SYNGR2SOX130.687572403
SYNGR2SYT170.686626303

For details and further investigation, click here