PRKCG

 

Full name: protein kinase C gamma Alias Symbol: PKCC|MGC57564|PKCγ
Type: protein-coding gene Cytoband: 19q13.42
Entrez ID: 5582 HGNC ID: HGNC:9402 Ensembl Gene: ENSG00000126583 OMIM ID: 176980
Drug and gene relationship at DGIdb

 

PRKCG involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04012ErbB signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04020Calcium signaling pathway
hsa04066HIF-1 signaling pathway
hsa04071Sphingolipid signaling pathway
hsa04270Vascular smooth muscle contraction
hsa04310Wnt signaling pathway
hsa04370VEGF signaling pathway
hsa04510Focal adhesion
hsa04530Tight junction
hsa04540Gap junction
hsa04650Natural killer cell mediated cytotoxicity
hsa04666Fc gamma R-mediated phagocytosis
hsa04670Leukocyte transendothelial migration
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04911Insulin secretion
hsa04916Melanogenesis
hsa04918Thyroid hormone synthesis
hsa04919Thyroid hormone signaling pathway
hsa04921Oxytocin signaling pathway
hsa04925Aldosterone synthesis and secretion
hsa04961Endocrine and other factor-regulated calcium reabsorption
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05031Amphetamine addiction
hsa05032Morphine addiction
hsa05161Hepatitis B
hsa05200Pathways in cancer
hsa05205Proteoglycans in cancer
hsa05214Glioma
hsa05223Non-small cell lung cancer
hsa05231Choline metabolism in cancer

 

Expression of PRKCG:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKCG 5582 236195_x_at 0.1130 0.5885
GSE20347 PRKCG 5582 206270_at -0.0612 0.2893
GSE23400 PRKCG 5582 206270_at -0.1159 0.0031
GSE26886 PRKCG 5582 206270_at 0.1569 0.2719
GSE29001 PRKCG 5582 206270_at -0.0863 0.5722
GSE38129 PRKCG 5582 206270_at -0.1251 0.0552
GSE45670 PRKCG 5582 236195_x_at -0.0327 0.6866
GSE53622 PRKCG 5582 22123 0.4513 0.0000
GSE53624 PRKCG 5582 22123 0.6170 0.0000
GSE63941 PRKCG 5582 236195_x_at 0.1734 0.2091
GSE77861 PRKCG 5582 206270_at -0.0910 0.4227
GSE97050 PRKCG 5582 A_23_P16189 0.0455 0.8834
TCGA PRKCG 5582 RNAseq -1.9235 0.0172

Upregulated datasets: 0; Downregulated datasets: 1.  

 

Survival by PRKCG expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKCG:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKCG 5582 3 4 23
GSE20123 PRKCG 5582 3 3 24
GSE43470 PRKCG 5582 2 11 30
GSE46452 PRKCG 5582 45 1 13
GSE47630 PRKCG 5582 8 6 26
GSE54993 PRKCG 5582 17 4 49
GSE54994 PRKCG 5582 4 14 35
GSE60625 PRKCG 5582 9 0 2
GSE74703 PRKCG 5582 2 7 27
GSE74704 PRKCG 5582 3 1 16
TCGA PRKCG 5582 18 16 62

Total number of gains: 114; Total number of losses: 67; Total Number of normals: 307.  

 

Somatic mutations of PRKCG:

 

Generating mutation plots.

 

Highly correlated genes for PRKCG:

 

Showing top 20/801 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKCGDCDC10.801009303
PRKCGLIME10.784784303
PRKCGSTRC0.777849303
PRKCGZNF8430.765146303
PRKCGSPACA30.757778303
PRKCGC2CD4D0.751578303
PRKCGFMR1NB0.751431404
PRKCGSLC39A50.740344505
PRKCGOR2A50.73282303
PRKCGCLTCL10.730629404
PRKCGOR2T10.730329303
PRKCGPLA2G2C0.727117303
PRKCGBLACE0.726958303
PRKCGLRRIQ30.723004303
PRKCGMYO1A0.721979303
PRKCGPABPN1L0.719303303
PRKCGC19orf710.718402303
PRKCGPHF10.71609303
PRKCGNTNG20.713916404
PRKCGBBC30.712681303

For details and further investigation, click here