| Full name: protein kinase C iota | Alias Symbol: PKCI | ||
| Type: protein-coding gene | Cytoband: 3q26.2 | ||
| Entrez ID: 5584 | HGNC ID: HGNC:9404 | Ensembl Gene: ENSG00000163558 | OMIM ID: 600539 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
PRKCI involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04530 | Tight junction | |
| hsa04611 | Platelet activation | |
| hsa04910 | Insulin signaling pathway |
Expression of PRKCI:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKCI | 5584 | 209678_s_at | 0.6557 | 0.2094 | |
| GSE20347 | PRKCI | 5584 | 209678_s_at | 0.3033 | 0.0589 | |
| GSE23400 | PRKCI | 5584 | 209678_s_at | 0.1804 | 0.1529 | |
| GSE26886 | PRKCI | 5584 | 209678_s_at | -1.0260 | 0.0065 | |
| GSE29001 | PRKCI | 5584 | 213518_at | 0.3309 | 0.2106 | |
| GSE38129 | PRKCI | 5584 | 209678_s_at | 0.4194 | 0.2099 | |
| GSE45670 | PRKCI | 5584 | 213518_at | 0.4226 | 0.0444 | |
| GSE53622 | PRKCI | 5584 | 94873 | 0.6179 | 0.0000 | |
| GSE53624 | PRKCI | 5584 | 94873 | 0.5129 | 0.0000 | |
| GSE63941 | PRKCI | 5584 | 209678_s_at | 1.4379 | 0.0086 | |
| GSE77861 | PRKCI | 5584 | 209678_s_at | 0.6814 | 0.0566 | |
| GSE97050 | PRKCI | 5584 | A_33_P3294578 | 0.1768 | 0.4582 | |
| SRP007169 | PRKCI | 5584 | RNAseq | -0.2092 | 0.5202 | |
| SRP008496 | PRKCI | 5584 | RNAseq | 0.2312 | 0.2687 | |
| SRP064894 | PRKCI | 5584 | RNAseq | 0.1901 | 0.4684 | |
| SRP133303 | PRKCI | 5584 | RNAseq | 0.8732 | 0.0000 | |
| SRP159526 | PRKCI | 5584 | RNAseq | 0.7737 | 0.0664 | |
| SRP193095 | PRKCI | 5584 | RNAseq | 0.1447 | 0.2840 | |
| SRP219564 | PRKCI | 5584 | RNAseq | -0.1635 | 0.6618 | |
| TCGA | PRKCI | 5584 | RNAseq | 0.0584 | 0.2767 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by PRKCI expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRKCI:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKCI | 5584 | 22 | 0 | 8 | |
| GSE20123 | PRKCI | 5584 | 22 | 0 | 8 | |
| GSE43470 | PRKCI | 5584 | 24 | 0 | 19 | |
| GSE46452 | PRKCI | 5584 | 19 | 1 | 39 | |
| GSE47630 | PRKCI | 5584 | 27 | 2 | 11 | |
| GSE54993 | PRKCI | 5584 | 1 | 14 | 55 | |
| GSE54994 | PRKCI | 5584 | 41 | 0 | 12 | |
| GSE60625 | PRKCI | 5584 | 0 | 6 | 5 | |
| GSE74703 | PRKCI | 5584 | 20 | 0 | 16 | |
| GSE74704 | PRKCI | 5584 | 14 | 0 | 6 | |
| TCGA | PRKCI | 5584 | 80 | 0 | 16 |
Total number of gains: 270; Total number of losses: 23; Total Number of normals: 195.
Somatic mutations of PRKCI:
Generating mutation plots.
Highly correlated genes for PRKCI:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKCI | NOM1 | 0.823614 | 3 | 0 | 3 |
| PRKCI | FAM185A | 0.771964 | 3 | 0 | 3 |
| PRKCI | METAP1D | 0.767565 | 3 | 0 | 3 |
| PRKCI | DNAJC13 | 0.760113 | 3 | 0 | 3 |
| PRKCI | DDX59 | 0.755509 | 3 | 0 | 3 |
| PRKCI | LMLN | 0.755505 | 4 | 0 | 4 |
| PRKCI | ZNF75A | 0.751442 | 3 | 0 | 3 |
| PRKCI | ZNF669 | 0.741111 | 3 | 0 | 3 |
| PRKCI | MRPS5 | 0.739028 | 3 | 0 | 3 |
| PRKCI | SCAF1 | 0.733595 | 3 | 0 | 3 |
| PRKCI | GATA1 | 0.725442 | 3 | 0 | 3 |
| PRKCI | LRRC58 | 0.718059 | 5 | 0 | 5 |
| PRKCI | SPIRE2 | 0.713998 | 3 | 0 | 3 |
| PRKCI | SLC25A16 | 0.713052 | 5 | 0 | 5 |
| PRKCI | MAD2L2 | 0.708843 | 3 | 0 | 3 |
| PRKCI | DHX36 | 0.708575 | 8 | 0 | 7 |
| PRKCI | RAB12 | 0.706357 | 3 | 0 | 3 |
| PRKCI | SLC35E1 | 0.704154 | 4 | 0 | 4 |
| PRKCI | TMEM138 | 0.702398 | 4 | 0 | 3 |
| PRKCI | ADPRH | 0.701737 | 3 | 0 | 3 |
For details and further investigation, click here
