| Full name: protein kinase D2 | Alias Symbol: PKD2|HSPC187|DKFZP586E0820 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 25865 | HGNC ID: HGNC:17293 | Ensembl Gene: ENSG00000105287 | OMIM ID: 607074 |
| Drug and gene relationship at DGIdb | |||
PRKD2 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway | |
| hsa04925 | Aldosterone synthesis and secretion |
Expression of PRKD2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRKD2 | 25865 | 38269_at | 0.3870 | 0.4142 | |
| GSE20347 | PRKD2 | 25865 | 38269_at | -0.1013 | 0.3850 | |
| GSE23400 | PRKD2 | 25865 | 38269_at | 0.0983 | 0.1443 | |
| GSE26886 | PRKD2 | 25865 | 38269_at | 0.1539 | 0.4200 | |
| GSE29001 | PRKD2 | 25865 | 38269_at | 0.1465 | 0.5440 | |
| GSE38129 | PRKD2 | 25865 | 38269_at | 0.0214 | 0.8460 | |
| GSE45670 | PRKD2 | 25865 | 38269_at | 0.1546 | 0.2566 | |
| GSE53622 | PRKD2 | 25865 | 103571 | 0.0820 | 0.2727 | |
| GSE53624 | PRKD2 | 25865 | 103571 | 0.0615 | 0.1924 | |
| GSE63941 | PRKD2 | 25865 | 38269_at | 0.2459 | 0.3469 | |
| GSE77861 | PRKD2 | 25865 | 241669_x_at | -0.1795 | 0.4558 | |
| GSE97050 | PRKD2 | 25865 | A_23_P78802 | 0.3455 | 0.2942 | |
| SRP007169 | PRKD2 | 25865 | RNAseq | -0.2031 | 0.6077 | |
| SRP008496 | PRKD2 | 25865 | RNAseq | -0.3203 | 0.2191 | |
| SRP064894 | PRKD2 | 25865 | RNAseq | 0.4591 | 0.0387 | |
| SRP133303 | PRKD2 | 25865 | RNAseq | 0.0002 | 0.9991 | |
| SRP159526 | PRKD2 | 25865 | RNAseq | 0.2824 | 0.1020 | |
| SRP193095 | PRKD2 | 25865 | RNAseq | 0.1474 | 0.3234 | |
| SRP219564 | PRKD2 | 25865 | RNAseq | -0.1006 | 0.7714 | |
| TCGA | PRKD2 | 25865 | RNAseq | 0.1345 | 0.0046 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PRKD2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRKD2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRKD2 | 25865 | 4 | 4 | 22 | |
| GSE20123 | PRKD2 | 25865 | 4 | 3 | 23 | |
| GSE43470 | PRKD2 | 25865 | 3 | 11 | 29 | |
| GSE46452 | PRKD2 | 25865 | 45 | 1 | 13 | |
| GSE47630 | PRKD2 | 25865 | 8 | 7 | 25 | |
| GSE54993 | PRKD2 | 25865 | 17 | 4 | 49 | |
| GSE54994 | PRKD2 | 25865 | 5 | 13 | 35 | |
| GSE60625 | PRKD2 | 25865 | 9 | 0 | 2 | |
| GSE74703 | PRKD2 | 25865 | 3 | 7 | 26 | |
| GSE74704 | PRKD2 | 25865 | 4 | 1 | 15 | |
| TCGA | PRKD2 | 25865 | 16 | 16 | 64 |
Total number of gains: 118; Total number of losses: 67; Total Number of normals: 303.
Somatic mutations of PRKD2:
Generating mutation plots.
Highly correlated genes for PRKD2:
Showing top 20/317 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRKD2 | ATAD3B | 0.795817 | 3 | 0 | 3 |
| PRKD2 | ACAD9 | 0.773293 | 3 | 0 | 3 |
| PRKD2 | ADAM15 | 0.731642 | 3 | 0 | 3 |
| PRKD2 | RCC1 | 0.704907 | 3 | 0 | 3 |
| PRKD2 | SOX4 | 0.698654 | 3 | 0 | 3 |
| PRKD2 | ARHGEF19 | 0.6963 | 4 | 0 | 4 |
| PRKD2 | TFR2 | 0.689102 | 3 | 0 | 3 |
| PRKD2 | ACP2 | 0.675393 | 3 | 0 | 3 |
| PRKD2 | GTF2H4 | 0.675227 | 4 | 0 | 3 |
| PRKD2 | ATXN7L3 | 0.667321 | 4 | 0 | 3 |
| PRKD2 | ZXDC | 0.66714 | 3 | 0 | 3 |
| PRKD2 | MSLN | 0.666968 | 3 | 0 | 3 |
| PRKD2 | CNPY3 | 0.666471 | 3 | 0 | 3 |
| PRKD2 | SLC29A3 | 0.655775 | 3 | 0 | 3 |
| PRKD2 | UBE2O | 0.655375 | 3 | 0 | 3 |
| PRKD2 | OLFM1 | 0.65207 | 3 | 0 | 3 |
| PRKD2 | INTS9 | 0.647559 | 3 | 0 | 3 |
| PRKD2 | SSTR5 | 0.647429 | 3 | 0 | 3 |
| PRKD2 | CTSZ | 0.646853 | 3 | 0 | 3 |
| PRKD2 | LHX5 | 0.645618 | 3 | 0 | 3 |
For details and further investigation, click here
