| Full name: SRY-box transcription factor 4 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 6659 | HGNC ID: HGNC:11200 | Ensembl Gene: ENSG00000124766 | OMIM ID: 184430 |
| Drug and gene relationship at DGIdb | |||
Expression of SOX4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SOX4 | 6659 | 201417_at | 1.3984 | 0.0567 | |
| GSE20347 | SOX4 | 6659 | 201417_at | 1.9127 | 0.0000 | |
| GSE23400 | SOX4 | 6659 | 201417_at | 1.9966 | 0.0000 | |
| GSE26886 | SOX4 | 6659 | 201417_at | 1.5770 | 0.0000 | |
| GSE29001 | SOX4 | 6659 | 201416_at | 1.2107 | 0.0287 | |
| GSE38129 | SOX4 | 6659 | 201417_at | 2.1235 | 0.0000 | |
| GSE45670 | SOX4 | 6659 | 201417_at | 1.4165 | 0.0001 | |
| GSE53622 | SOX4 | 6659 | 39979 | 1.7564 | 0.0000 | |
| GSE53624 | SOX4 | 6659 | 39979 | 1.5716 | 0.0000 | |
| GSE63941 | SOX4 | 6659 | 201417_at | -1.7650 | 0.0376 | |
| GSE77861 | SOX4 | 6659 | 201417_at | 1.9965 | 0.0004 | |
| GSE97050 | SOX4 | 6659 | A_24_P911676 | 1.4930 | 0.0555 | |
| SRP007169 | SOX4 | 6659 | RNAseq | 3.3616 | 0.0000 | |
| SRP008496 | SOX4 | 6659 | RNAseq | 3.3507 | 0.0000 | |
| SRP064894 | SOX4 | 6659 | RNAseq | 2.0237 | 0.0000 | |
| SRP133303 | SOX4 | 6659 | RNAseq | 1.8320 | 0.0000 | |
| SRP159526 | SOX4 | 6659 | RNAseq | 2.5835 | 0.0000 | |
| SRP193095 | SOX4 | 6659 | RNAseq | 1.2170 | 0.0000 | |
| SRP219564 | SOX4 | 6659 | RNAseq | 1.7073 | 0.0000 | |
| TCGA | SOX4 | 6659 | RNAseq | 0.2442 | 0.0023 |
Upregulated datasets: 16; Downregulated datasets: 1.
Survival by SOX4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SOX4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SOX4 | 6659 | 4 | 3 | 23 | |
| GSE20123 | SOX4 | 6659 | 4 | 3 | 23 | |
| GSE43470 | SOX4 | 6659 | 10 | 0 | 33 | |
| GSE46452 | SOX4 | 6659 | 1 | 9 | 49 | |
| GSE47630 | SOX4 | 6659 | 10 | 4 | 26 | |
| GSE54993 | SOX4 | 6659 | 1 | 1 | 68 | |
| GSE54994 | SOX4 | 6659 | 12 | 3 | 38 | |
| GSE60625 | SOX4 | 6659 | 0 | 1 | 10 | |
| GSE74703 | SOX4 | 6659 | 9 | 0 | 27 | |
| GSE74704 | SOX4 | 6659 | 1 | 1 | 18 | |
| TCGA | SOX4 | 6659 | 18 | 22 | 56 |
Total number of gains: 70; Total number of losses: 47; Total Number of normals: 371.
Somatic mutations of SOX4:
Generating mutation plots.
Highly correlated genes for SOX4:
Showing top 20/1751 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SOX4 | PYCR2 | 0.781407 | 3 | 0 | 3 |
| SOX4 | PLXNA1 | 0.775925 | 11 | 0 | 11 |
| SOX4 | GORAB | 0.768803 | 7 | 0 | 7 |
| SOX4 | MARCKSL1 | 0.767803 | 13 | 0 | 12 |
| SOX4 | PXYLP1 | 0.765202 | 6 | 0 | 6 |
| SOX4 | FZD6 | 0.762465 | 8 | 0 | 8 |
| SOX4 | DNMT1 | 0.760056 | 11 | 0 | 11 |
| SOX4 | WDR81 | 0.747837 | 5 | 0 | 5 |
| SOX4 | TMEM63B | 0.745011 | 3 | 0 | 3 |
| SOX4 | TOPBP1 | 0.744104 | 10 | 0 | 10 |
| SOX4 | RNF166 | 0.742816 | 3 | 0 | 3 |
| SOX4 | SPON2 | 0.737216 | 3 | 0 | 3 |
| SOX4 | SLC35B2 | 0.735593 | 3 | 0 | 3 |
| SOX4 | LRRC58 | 0.734869 | 5 | 0 | 5 |
| SOX4 | STMN1 | 0.73432 | 12 | 0 | 12 |
| SOX4 | RPGR | 0.729549 | 3 | 0 | 3 |
| SOX4 | SLC39A10 | 0.724825 | 7 | 0 | 7 |
| SOX4 | TCF3 | 0.724785 | 11 | 0 | 10 |
| SOX4 | SLC39A3 | 0.724277 | 4 | 0 | 4 |
| SOX4 | EXOC6 | 0.723533 | 4 | 0 | 4 |
For details and further investigation, click here
