| Full name: general transcription factor IIH subunit 4 | Alias Symbol: TFB2|TFIIH|P52 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 2968 | HGNC ID: HGNC:4658 | Ensembl Gene: ENSG00000213780 | OMIM ID: 601760 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of GTF2H4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GTF2H4 | 2968 | 203577_at | 0.6042 | 0.2726 | |
| GSE20347 | GTF2H4 | 2968 | 203577_at | 0.1202 | 0.3165 | |
| GSE23400 | GTF2H4 | 2968 | 203577_at | 0.3399 | 0.0000 | |
| GSE26886 | GTF2H4 | 2968 | 203577_at | 0.4473 | 0.0043 | |
| GSE29001 | GTF2H4 | 2968 | 203577_at | 0.2784 | 0.4168 | |
| GSE38129 | GTF2H4 | 2968 | 203577_at | 0.4620 | 0.0530 | |
| GSE45670 | GTF2H4 | 2968 | 203577_at | 0.2019 | 0.2035 | |
| GSE53622 | GTF2H4 | 2968 | 34001 | 0.4330 | 0.0000 | |
| GSE53624 | GTF2H4 | 2968 | 34001 | 0.4242 | 0.0000 | |
| GSE63941 | GTF2H4 | 2968 | 203577_at | 1.1382 | 0.0167 | |
| GSE77861 | GTF2H4 | 2968 | 203577_at | 0.2394 | 0.3719 | |
| GSE97050 | GTF2H4 | 2968 | A_23_P251259 | 0.4547 | 0.1505 | |
| SRP007169 | GTF2H4 | 2968 | RNAseq | 0.3574 | 0.4679 | |
| SRP064894 | GTF2H4 | 2968 | RNAseq | 0.5962 | 0.0004 | |
| SRP133303 | GTF2H4 | 2968 | RNAseq | 0.0640 | 0.6963 | |
| SRP159526 | GTF2H4 | 2968 | RNAseq | 0.2859 | 0.3055 | |
| SRP193095 | GTF2H4 | 2968 | RNAseq | 0.3288 | 0.0016 | |
| SRP219564 | GTF2H4 | 2968 | RNAseq | -0.0146 | 0.9407 | |
| TCGA | GTF2H4 | 2968 | RNAseq | 0.2325 | 0.0001 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by GTF2H4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GTF2H4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GTF2H4 | 2968 | 5 | 1 | 24 | |
| GSE20123 | GTF2H4 | 2968 | 5 | 1 | 24 | |
| GSE43470 | GTF2H4 | 2968 | 6 | 1 | 36 | |
| GSE46452 | GTF2H4 | 2968 | 1 | 10 | 48 | |
| GSE47630 | GTF2H4 | 2968 | 7 | 3 | 30 | |
| GSE54993 | GTF2H4 | 2968 | 2 | 1 | 67 | |
| GSE54994 | GTF2H4 | 2968 | 11 | 4 | 38 | |
| GSE60625 | GTF2H4 | 2968 | 0 | 1 | 10 | |
| GSE74703 | GTF2H4 | 2968 | 6 | 0 | 30 | |
| GSE74704 | GTF2H4 | 2968 | 2 | 0 | 18 | |
| TCGA | GTF2H4 | 2968 | 18 | 16 | 62 |
Total number of gains: 63; Total number of losses: 38; Total Number of normals: 387.
Somatic mutations of GTF2H4:
Generating mutation plots.
Highly correlated genes for GTF2H4:
Showing top 20/656 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GTF2H4 | PRKCZ | 0.753738 | 3 | 0 | 3 |
| GTF2H4 | POP1 | 0.728819 | 3 | 0 | 3 |
| GTF2H4 | ZNF668 | 0.695126 | 4 | 0 | 4 |
| GTF2H4 | LINC01128 | 0.687044 | 3 | 0 | 3 |
| GTF2H4 | PRKD2 | 0.675227 | 4 | 0 | 3 |
| GTF2H4 | UBE2J2 | 0.669195 | 3 | 0 | 3 |
| GTF2H4 | DHX16 | 0.668672 | 10 | 0 | 9 |
| GTF2H4 | ZNF77 | 0.666489 | 3 | 0 | 3 |
| GTF2H4 | CNTROB | 0.659534 | 5 | 0 | 4 |
| GTF2H4 | WDR46 | 0.651962 | 11 | 0 | 9 |
| GTF2H4 | XPO5 | 0.64828 | 7 | 0 | 6 |
| GTF2H4 | SHKBP1 | 0.64545 | 4 | 0 | 3 |
| GTF2H4 | PIGW | 0.644585 | 3 | 0 | 3 |
| GTF2H4 | TSEN54 | 0.642083 | 4 | 0 | 4 |
| GTF2H4 | ABT1 | 0.63816 | 8 | 0 | 8 |
| GTF2H4 | KBTBD7 | 0.636001 | 3 | 0 | 3 |
| GTF2H4 | RPN2 | 0.63489 | 4 | 0 | 4 |
| GTF2H4 | EEF1E1 | 0.633465 | 7 | 0 | 6 |
| GTF2H4 | RPS19 | 0.632077 | 4 | 0 | 4 |
| GTF2H4 | TIGD1 | 0.631841 | 3 | 0 | 3 |
For details and further investigation, click here
