| Full name: cathepsin Z | Alias Symbol: CTSX | ||
| Type: protein-coding gene | Cytoband: 20q13.32 | ||
| Entrez ID: 1522 | HGNC ID: HGNC:2547 | Ensembl Gene: ENSG00000101160 | OMIM ID: 603169 |
| Drug and gene relationship at DGIdb | |||
CTSZ involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04210 | Apoptosis |
Expression of CTSZ:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CTSZ | 1522 | 210042_s_at | 0.6511 | 0.3617 | |
| GSE20347 | CTSZ | 1522 | 212562_s_at | -0.0326 | 0.6786 | |
| GSE23400 | CTSZ | 1522 | 210042_s_at | 0.4056 | 0.0233 | |
| GSE26886 | CTSZ | 1522 | 210042_s_at | 0.1667 | 0.6675 | |
| GSE29001 | CTSZ | 1522 | 210042_s_at | 0.9635 | 0.0116 | |
| GSE38129 | CTSZ | 1522 | 210042_s_at | 0.8048 | 0.2243 | |
| GSE45670 | CTSZ | 1522 | 210042_s_at | 0.0447 | 0.9081 | |
| GSE53622 | CTSZ | 1522 | 15988 | 1.0446 | 0.0000 | |
| GSE53624 | CTSZ | 1522 | 15988 | 1.1366 | 0.0000 | |
| GSE63941 | CTSZ | 1522 | 212562_s_at | 0.1481 | 0.1650 | |
| GSE77861 | CTSZ | 1522 | 212562_s_at | 0.0462 | 0.7767 | |
| GSE97050 | CTSZ | 1522 | A_23_P40240 | 0.6125 | 0.1241 | |
| SRP007169 | CTSZ | 1522 | RNAseq | 2.7412 | 0.0000 | |
| SRP008496 | CTSZ | 1522 | RNAseq | 2.6394 | 0.0000 | |
| SRP064894 | CTSZ | 1522 | RNAseq | 1.5067 | 0.0000 | |
| SRP133303 | CTSZ | 1522 | RNAseq | 1.2951 | 0.0000 | |
| SRP159526 | CTSZ | 1522 | RNAseq | 1.0456 | 0.0046 | |
| SRP193095 | CTSZ | 1522 | RNAseq | 0.7898 | 0.0045 | |
| SRP219564 | CTSZ | 1522 | RNAseq | 1.2111 | 0.0423 | |
| TCGA | CTSZ | 1522 | RNAseq | 0.1895 | 0.0058 |
Upregulated datasets: 8; Downregulated datasets: 0.
Survival by CTSZ expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CTSZ:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CTSZ | 1522 | 14 | 2 | 14 | |
| GSE20123 | CTSZ | 1522 | 14 | 2 | 14 | |
| GSE43470 | CTSZ | 1522 | 13 | 0 | 30 | |
| GSE46452 | CTSZ | 1522 | 29 | 0 | 30 | |
| GSE47630 | CTSZ | 1522 | 24 | 1 | 15 | |
| GSE54993 | CTSZ | 1522 | 0 | 17 | 53 | |
| GSE54994 | CTSZ | 1522 | 29 | 0 | 24 | |
| GSE60625 | CTSZ | 1522 | 0 | 0 | 11 | |
| GSE74703 | CTSZ | 1522 | 11 | 0 | 25 | |
| GSE74704 | CTSZ | 1522 | 11 | 0 | 9 | |
| TCGA | CTSZ | 1522 | 43 | 4 | 49 |
Total number of gains: 188; Total number of losses: 26; Total Number of normals: 274.
Somatic mutations of CTSZ:
Generating mutation plots.
Highly correlated genes for CTSZ:
Showing top 20/564 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CTSZ | FCGR3A | 0.821165 | 3 | 0 | 3 |
| CTSZ | USE1 | 0.731967 | 3 | 0 | 3 |
| CTSZ | LRRC8C | 0.709616 | 3 | 0 | 3 |
| CTSZ | GNAI2 | 0.708742 | 3 | 0 | 3 |
| CTSZ | SNAP47 | 0.704019 | 3 | 0 | 3 |
| CTSZ | PRTFDC1 | 0.699368 | 5 | 0 | 5 |
| CTSZ | FMNL3 | 0.695065 | 6 | 0 | 6 |
| CTSZ | VAPB | 0.692981 | 3 | 0 | 3 |
| CTSZ | ZFP1 | 0.690144 | 3 | 0 | 3 |
| CTSZ | RAB42 | 0.689931 | 3 | 0 | 3 |
| CTSZ | SLC35B2 | 0.686771 | 3 | 0 | 3 |
| CTSZ | CYBA | 0.683147 | 5 | 0 | 5 |
| CTSZ | LSM4 | 0.68157 | 3 | 0 | 3 |
| CTSZ | CYTH4 | 0.679189 | 4 | 0 | 4 |
| CTSZ | RAB34 | 0.677663 | 3 | 0 | 3 |
| CTSZ | DDHD1 | 0.674303 | 5 | 0 | 5 |
| CTSZ | MS4A14 | 0.671049 | 3 | 0 | 3 |
| CTSZ | PYCR2 | 0.670948 | 3 | 0 | 3 |
| CTSZ | FNDC3B | 0.668947 | 7 | 0 | 6 |
| CTSZ | GNA12 | 0.668605 | 7 | 0 | 7 |
For details and further investigation, click here
