PRKD3

 

Full name: protein kinase D3 Alias Symbol: EPK2
Type: protein-coding gene Cytoband: 2p22.2
Entrez ID: 23683 HGNC ID: HGNC:9408 Ensembl Gene: ENSG00000115825 OMIM ID: 607077
Drug and gene relationship at DGIdb

 

PRKD3 involved pathways:

KEGG pathway Description View
hsa04015Rap1 signaling pathway
hsa04925Aldosterone synthesis and secretion

 

Expression of PRKD3:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PRKD3 23683 218236_s_at 0.2093 0.7146
GSE20347 PRKD3 23683 211084_x_at 0.5277 0.0037
GSE23400 PRKD3 23683 211084_x_at 0.2603 0.0000
GSE26886 PRKD3 23683 218236_s_at 0.5826 0.1189
GSE29001 PRKD3 23683 211084_x_at 0.2542 0.3332
GSE38129 PRKD3 23683 218236_s_at 0.0553 0.8510
GSE45670 PRKD3 23683 218236_s_at -0.3036 0.2583
GSE53622 PRKD3 23683 28692 0.4966 0.0000
GSE53624 PRKD3 23683 10732 -0.0269 0.8349
GSE63941 PRKD3 23683 218236_s_at -0.4749 0.2384
GSE77861 PRKD3 23683 218236_s_at -0.1613 0.6412
GSE97050 PRKD3 23683 A_24_P165656 0.0815 0.7609
SRP007169 PRKD3 23683 RNAseq 0.8224 0.0346
SRP008496 PRKD3 23683 RNAseq 0.8333 0.0003
SRP064894 PRKD3 23683 RNAseq 0.4124 0.0280
SRP133303 PRKD3 23683 RNAseq 0.1740 0.0942
SRP159526 PRKD3 23683 RNAseq 0.3991 0.2470
SRP193095 PRKD3 23683 RNAseq 0.3241 0.0018
SRP219564 PRKD3 23683 RNAseq 0.1141 0.5871
TCGA PRKD3 23683 RNAseq -0.0299 0.6105

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by PRKD3 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PRKD3:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PRKD3 23683 10 1 19
GSE20123 PRKD3 23683 9 1 20
GSE43470 PRKD3 23683 3 0 40
GSE46452 PRKD3 23683 1 4 54
GSE47630 PRKD3 23683 7 0 33
GSE54993 PRKD3 23683 0 5 65
GSE54994 PRKD3 23683 10 0 43
GSE60625 PRKD3 23683 0 3 8
GSE74703 PRKD3 23683 3 0 33
GSE74704 PRKD3 23683 9 1 10
TCGA PRKD3 23683 35 2 59

Total number of gains: 87; Total number of losses: 17; Total Number of normals: 384.  

 

Somatic mutations of PRKD3:

 

Generating mutation plots.

 

Highly correlated genes for PRKD3:

 

Showing top 20/743 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PRKD3RAB39B0.810517303
PRKD3RGS180.808131303
PRKD3ZDHHC70.775586303
PRKD3TTC80.761127303
PRKD3P2RY130.743312303
PRKD3DYRK20.74275303
PRKD3ACBD50.729311303
PRKD3FAM161A0.714773303
PRKD3KLHL50.709874504
PRKD3PDE7A0.705376303
PRKD3GIMAP10.704881403
PRKD3SNX200.703438303
PRKD3NF10.696591303
PRKD3SAFB20.696352303
PRKD3TYW30.691487404
PRKD3MTO10.69041303
PRKD3TSPAN40.689818505
PRKD3ZNF2600.688639303
PRKD3SMCR80.688616303
PRKD3SGTB0.68627403

For details and further investigation, click here