| Full name: tetratricopeptide repeat domain 8 | Alias Symbol: BBS8|RP51 | ||
| Type: protein-coding gene | Cytoband: 14q31.3 | ||
| Entrez ID: 123016 | HGNC ID: HGNC:20087 | Ensembl Gene: ENSG00000165533 | OMIM ID: 608132 |
| Drug and gene relationship at DGIdb | |||
Expression of TTC8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TTC8 | 123016 | 226120_at | -0.1969 | 0.7713 | |
| GSE26886 | TTC8 | 123016 | 226120_at | 0.4341 | 0.0592 | |
| GSE45670 | TTC8 | 123016 | 226120_at | -0.0410 | 0.8653 | |
| GSE53622 | TTC8 | 123016 | 5620 | 0.0968 | 0.2797 | |
| GSE53624 | TTC8 | 123016 | 45917 | 0.2290 | 0.0116 | |
| GSE63941 | TTC8 | 123016 | 226120_at | -1.3693 | 0.0084 | |
| GSE77861 | TTC8 | 123016 | 226120_at | 0.5162 | 0.4340 | |
| GSE97050 | TTC8 | 123016 | A_32_P169735 | 0.2019 | 0.4743 | |
| SRP007169 | TTC8 | 123016 | RNAseq | -0.2148 | 0.6336 | |
| SRP008496 | TTC8 | 123016 | RNAseq | 0.1200 | 0.7106 | |
| SRP064894 | TTC8 | 123016 | RNAseq | 0.2817 | 0.1148 | |
| SRP133303 | TTC8 | 123016 | RNAseq | 0.4586 | 0.0121 | |
| SRP159526 | TTC8 | 123016 | RNAseq | 0.2307 | 0.4769 | |
| SRP193095 | TTC8 | 123016 | RNAseq | 0.0869 | 0.4878 | |
| SRP219564 | TTC8 | 123016 | RNAseq | 0.1160 | 0.7862 | |
| TCGA | TTC8 | 123016 | RNAseq | 0.1500 | 0.0252 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by TTC8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TTC8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TTC8 | 123016 | 7 | 4 | 19 | |
| GSE20123 | TTC8 | 123016 | 8 | 4 | 18 | |
| GSE43470 | TTC8 | 123016 | 7 | 3 | 33 | |
| GSE46452 | TTC8 | 123016 | 16 | 3 | 40 | |
| GSE47630 | TTC8 | 123016 | 11 | 8 | 21 | |
| GSE54993 | TTC8 | 123016 | 3 | 8 | 59 | |
| GSE54994 | TTC8 | 123016 | 19 | 4 | 30 | |
| GSE60625 | TTC8 | 123016 | 0 | 2 | 9 | |
| GSE74703 | TTC8 | 123016 | 6 | 3 | 27 | |
| GSE74704 | TTC8 | 123016 | 4 | 4 | 12 | |
| TCGA | TTC8 | 123016 | 30 | 21 | 45 |
Total number of gains: 111; Total number of losses: 64; Total Number of normals: 313.
Somatic mutations of TTC8:
Generating mutation plots.
Highly correlated genes for TTC8:
Showing top 20/462 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TTC8 | RPE | 0.811549 | 3 | 0 | 3 |
| TTC8 | PHF3 | 0.778001 | 4 | 0 | 4 |
| TTC8 | SIRT1 | 0.762073 | 3 | 0 | 3 |
| TTC8 | PRKD3 | 0.761127 | 3 | 0 | 3 |
| TTC8 | GPATCH2 | 0.759366 | 3 | 0 | 3 |
| TTC8 | PTCD2 | 0.757362 | 3 | 0 | 3 |
| TTC8 | DGKH | 0.754657 | 3 | 0 | 3 |
| TTC8 | PTK2 | 0.751937 | 3 | 0 | 3 |
| TTC8 | CCNH | 0.751854 | 3 | 0 | 3 |
| TTC8 | ARHGAP24 | 0.751047 | 3 | 0 | 3 |
| TTC8 | NOL11 | 0.750851 | 3 | 0 | 3 |
| TTC8 | LMNA | 0.747516 | 3 | 0 | 3 |
| TTC8 | S1PR3 | 0.744675 | 3 | 0 | 3 |
| TTC8 | KDSR | 0.744446 | 3 | 0 | 3 |
| TTC8 | BMPR2 | 0.743202 | 3 | 0 | 3 |
| TTC8 | RGMB | 0.740162 | 3 | 0 | 3 |
| TTC8 | SCAMP1 | 0.737352 | 4 | 0 | 4 |
| TTC8 | DHX33 | 0.736871 | 3 | 0 | 3 |
| TTC8 | DHRS7 | 0.732221 | 4 | 0 | 4 |
| TTC8 | SLC35A1 | 0.728137 | 3 | 0 | 3 |
For details and further investigation, click here
