| Full name: nuclear speckle splicing regulatory protein 1 | Alias Symbol: DKFZP434K1421|NSrp70 | ||
| Type: protein-coding gene | Cytoband: 17q11.2 | ||
| Entrez ID: 84081 | HGNC ID: HGNC:25305 | Ensembl Gene: ENSG00000126653 | OMIM ID: 616173 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of NSRP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | NSRP1 | 84081 | 223236_at | -0.4490 | 0.0550 | |
| GSE26886 | NSRP1 | 84081 | 223236_at | 0.2880 | 0.1997 | |
| GSE45670 | NSRP1 | 84081 | 223236_at | -0.1744 | 0.2198 | |
| GSE53622 | NSRP1 | 84081 | 113324 | -0.1203 | 0.0305 | |
| GSE53624 | NSRP1 | 84081 | 113324 | -0.2268 | 0.0000 | |
| GSE63941 | NSRP1 | 84081 | 223236_at | -0.4677 | 0.3405 | |
| GSE77861 | NSRP1 | 84081 | 223236_at | 0.5185 | 0.1376 | |
| GSE97050 | NSRP1 | 84081 | A_23_P27180 | -0.3911 | 0.1496 | |
| SRP007169 | NSRP1 | 84081 | RNAseq | 1.2429 | 0.0283 | |
| SRP008496 | NSRP1 | 84081 | RNAseq | 0.9869 | 0.0231 | |
| SRP064894 | NSRP1 | 84081 | RNAseq | 0.1486 | 0.1342 | |
| SRP133303 | NSRP1 | 84081 | RNAseq | -0.0108 | 0.9326 | |
| SRP159526 | NSRP1 | 84081 | RNAseq | -0.1374 | 0.3859 | |
| SRP193095 | NSRP1 | 84081 | RNAseq | 0.1463 | 0.3336 | |
| SRP219564 | NSRP1 | 84081 | RNAseq | -0.3992 | 0.1153 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by NSRP1 expression:
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| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of NSRP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | NSRP1 | 84081 | 7 | 2 | 21 | |
| GSE20123 | NSRP1 | 84081 | 8 | 2 | 20 | |
| GSE43470 | NSRP1 | 84081 | 0 | 1 | 42 | |
| GSE46452 | NSRP1 | 84081 | 33 | 1 | 25 | |
| GSE47630 | NSRP1 | 84081 | 7 | 1 | 32 | |
| GSE54993 | NSRP1 | 84081 | 2 | 3 | 65 | |
| GSE54994 | NSRP1 | 84081 | 7 | 5 | 41 | |
| GSE60625 | NSRP1 | 84081 | 4 | 0 | 7 | |
| GSE74703 | NSRP1 | 84081 | 0 | 1 | 35 | |
| GSE74704 | NSRP1 | 84081 | 5 | 2 | 13 | |
| TCGA | NSRP1 | 84081 | 20 | 10 | 66 |
Total number of gains: 93; Total number of losses: 28; Total Number of normals: 367.
Somatic mutations of NSRP1:
Generating mutation plots.
Highly correlated genes for NSRP1:
Showing top 20/206 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| NSRP1 | IK | 0.817787 | 3 | 0 | 3 |
| NSRP1 | PFDN1 | 0.779347 | 3 | 0 | 3 |
| NSRP1 | COMMD1 | 0.7694 | 3 | 0 | 3 |
| NSRP1 | PJA2 | 0.753715 | 3 | 0 | 3 |
| NSRP1 | CBX1 | 0.74741 | 3 | 0 | 3 |
| NSRP1 | SLC35A1 | 0.737508 | 3 | 0 | 3 |
| NSRP1 | XPC | 0.731617 | 3 | 0 | 3 |
| NSRP1 | TMEM131 | 0.725644 | 3 | 0 | 3 |
| NSRP1 | CDC40 | 0.723946 | 4 | 0 | 4 |
| NSRP1 | EIF2B4 | 0.723643 | 4 | 0 | 4 |
| NSRP1 | PRKRA | 0.723146 | 3 | 0 | 3 |
| NSRP1 | IL33 | 0.717476 | 3 | 0 | 3 |
| NSRP1 | FLII | 0.712771 | 3 | 0 | 3 |
| NSRP1 | SLU7 | 0.708625 | 3 | 0 | 3 |
| NSRP1 | MRPS27 | 0.704513 | 3 | 0 | 3 |
| NSRP1 | FIS1 | 0.702025 | 3 | 0 | 3 |
| NSRP1 | MBNL2 | 0.698677 | 3 | 0 | 3 |
| NSRP1 | LCA5 | 0.690229 | 3 | 0 | 3 |
| NSRP1 | UNK | 0.687737 | 3 | 0 | 3 |
| NSRP1 | TSG101 | 0.687119 | 3 | 0 | 3 |
For details and further investigation, click here
