| Full name: A-kinase anchoring protein 8 | Alias Symbol: AKAP95|DKFZp586B1222 | ||
| Type: protein-coding gene | Cytoband: 19p13.12 | ||
| Entrez ID: 10270 | HGNC ID: HGNC:378 | Ensembl Gene: ENSG00000105127 | OMIM ID: 604692 |
| Drug and gene relationship at DGIdb | |||
Expression of AKAP8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AKAP8 | 10270 | 203848_at | -0.2374 | 0.3004 | |
| GSE20347 | AKAP8 | 10270 | 203848_at | -0.0563 | 0.6509 | |
| GSE23400 | AKAP8 | 10270 | 203847_s_at | 0.2460 | 0.0000 | |
| GSE26886 | AKAP8 | 10270 | 203847_s_at | 0.6506 | 0.0002 | |
| GSE29001 | AKAP8 | 10270 | 203847_s_at | 0.6331 | 0.0106 | |
| GSE38129 | AKAP8 | 10270 | 203848_at | -0.0651 | 0.4744 | |
| GSE45670 | AKAP8 | 10270 | 203848_at | -0.1356 | 0.1764 | |
| GSE53622 | AKAP8 | 10270 | 60954 | -0.1940 | 0.0005 | |
| GSE53624 | AKAP8 | 10270 | 60954 | 0.0137 | 0.7545 | |
| GSE63941 | AKAP8 | 10270 | 203847_s_at | 0.3947 | 0.1841 | |
| GSE77861 | AKAP8 | 10270 | 203847_s_at | 0.2618 | 0.1492 | |
| GSE97050 | AKAP8 | 10270 | A_33_P3417950 | -0.2400 | 0.2622 | |
| SRP007169 | AKAP8 | 10270 | RNAseq | 1.1994 | 0.0149 | |
| SRP008496 | AKAP8 | 10270 | RNAseq | 1.4622 | 0.0002 | |
| SRP064894 | AKAP8 | 10270 | RNAseq | 0.1631 | 0.0686 | |
| SRP133303 | AKAP8 | 10270 | RNAseq | -0.0295 | 0.8247 | |
| SRP159526 | AKAP8 | 10270 | RNAseq | -0.2767 | 0.0868 | |
| SRP193095 | AKAP8 | 10270 | RNAseq | 0.1636 | 0.0437 | |
| SRP219564 | AKAP8 | 10270 | RNAseq | 0.2058 | 0.4870 | |
| TCGA | AKAP8 | 10270 | RNAseq | 0.0196 | 0.6998 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by AKAP8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AKAP8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AKAP8 | 10270 | 4 | 2 | 24 | |
| GSE20123 | AKAP8 | 10270 | 3 | 1 | 26 | |
| GSE43470 | AKAP8 | 10270 | 2 | 6 | 35 | |
| GSE46452 | AKAP8 | 10270 | 47 | 1 | 11 | |
| GSE47630 | AKAP8 | 10270 | 4 | 7 | 29 | |
| GSE54993 | AKAP8 | 10270 | 15 | 4 | 51 | |
| GSE54994 | AKAP8 | 10270 | 6 | 14 | 33 | |
| GSE60625 | AKAP8 | 10270 | 9 | 0 | 2 | |
| GSE74703 | AKAP8 | 10270 | 2 | 4 | 30 | |
| GSE74704 | AKAP8 | 10270 | 0 | 1 | 19 | |
| TCGA | AKAP8 | 10270 | 19 | 11 | 66 |
Total number of gains: 111; Total number of losses: 51; Total Number of normals: 326.
Somatic mutations of AKAP8:
Generating mutation plots.
Highly correlated genes for AKAP8:
Showing top 20/225 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AKAP8 | C2orf69 | 0.815336 | 3 | 0 | 3 |
| AKAP8 | PSMD1 | 0.807427 | 3 | 0 | 3 |
| AKAP8 | TLN2 | 0.802239 | 3 | 0 | 3 |
| AKAP8 | GNB5 | 0.769415 | 3 | 0 | 3 |
| AKAP8 | CDK5RAP2 | 0.767743 | 3 | 0 | 3 |
| AKAP8 | NKAP | 0.752503 | 3 | 0 | 3 |
| AKAP8 | MN1 | 0.751766 | 3 | 0 | 3 |
| AKAP8 | ZFHX3 | 0.751128 | 3 | 0 | 3 |
| AKAP8 | MAU2 | 0.735067 | 4 | 0 | 4 |
| AKAP8 | EXOC6 | 0.727794 | 3 | 0 | 3 |
| AKAP8 | PRKRA | 0.724316 | 3 | 0 | 3 |
| AKAP8 | TTC30B | 0.722971 | 3 | 0 | 3 |
| AKAP8 | CAMKK2 | 0.721891 | 3 | 0 | 3 |
| AKAP8 | HAUS7 | 0.720381 | 3 | 0 | 3 |
| AKAP8 | FOXJ2 | 0.714531 | 3 | 0 | 3 |
| AKAP8 | SOCS4 | 0.706813 | 3 | 0 | 3 |
| AKAP8 | GMPR2 | 0.705152 | 4 | 0 | 3 |
| AKAP8 | PPIE | 0.700599 | 4 | 0 | 4 |
| AKAP8 | NLK | 0.699439 | 3 | 0 | 3 |
| AKAP8 | SARNP | 0.698047 | 3 | 0 | 3 |
For details and further investigation, click here
