| Full name: leucine zipper tumor suppressor 2 | Alias Symbol: KIAA1813|LAPSER1 | ||
| Type: protein-coding gene | Cytoband: 10q24.31 | ||
| Entrez ID: 84445 | HGNC ID: HGNC:29381 | Ensembl Gene: ENSG00000107816 | OMIM ID: 610454 |
| Drug and gene relationship at DGIdb | |||
Expression of LZTS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LZTS2 | 84445 | 1555881_s_at | 0.1961 | 0.5709 | |
| GSE26886 | LZTS2 | 84445 | 224473_x_at | 0.6127 | 0.0036 | |
| GSE45670 | LZTS2 | 84445 | 1555881_s_at | -0.2026 | 0.1680 | |
| GSE53622 | LZTS2 | 84445 | 30859 | 0.1435 | 0.1042 | |
| GSE53624 | LZTS2 | 84445 | 30859 | 0.3078 | 0.0000 | |
| GSE63941 | LZTS2 | 84445 | 1555881_s_at | -0.8283 | 0.0483 | |
| GSE77861 | LZTS2 | 84445 | 224473_x_at | 0.1195 | 0.4114 | |
| GSE97050 | LZTS2 | 84445 | A_33_P3254666 | 0.0874 | 0.6803 | |
| SRP007169 | LZTS2 | 84445 | RNAseq | 0.3457 | 0.4373 | |
| SRP008496 | LZTS2 | 84445 | RNAseq | 0.5020 | 0.0731 | |
| SRP064894 | LZTS2 | 84445 | RNAseq | 0.5090 | 0.0672 | |
| SRP133303 | LZTS2 | 84445 | RNAseq | 0.0238 | 0.8982 | |
| SRP159526 | LZTS2 | 84445 | RNAseq | 0.3742 | 0.1584 | |
| SRP193095 | LZTS2 | 84445 | RNAseq | 0.4021 | 0.0005 | |
| SRP219564 | LZTS2 | 84445 | RNAseq | -0.0433 | 0.9232 | |
| TCGA | LZTS2 | 84445 | RNAseq | -0.0698 | 0.1812 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by LZTS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LZTS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LZTS2 | 84445 | 1 | 8 | 21 | |
| GSE20123 | LZTS2 | 84445 | 1 | 7 | 22 | |
| GSE43470 | LZTS2 | 84445 | 0 | 8 | 35 | |
| GSE46452 | LZTS2 | 84445 | 0 | 11 | 48 | |
| GSE47630 | LZTS2 | 84445 | 2 | 14 | 24 | |
| GSE54993 | LZTS2 | 84445 | 8 | 0 | 62 | |
| GSE54994 | LZTS2 | 84445 | 1 | 12 | 40 | |
| GSE60625 | LZTS2 | 84445 | 0 | 0 | 11 | |
| GSE74703 | LZTS2 | 84445 | 0 | 5 | 31 | |
| GSE74704 | LZTS2 | 84445 | 0 | 4 | 16 | |
| TCGA | LZTS2 | 84445 | 5 | 28 | 63 |
Total number of gains: 18; Total number of losses: 97; Total Number of normals: 373.
Somatic mutations of LZTS2:
Generating mutation plots.
Highly correlated genes for LZTS2:
Showing top 20/384 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LZTS2 | NDUFB4 | 0.730961 | 3 | 0 | 3 |
| LZTS2 | KRTCAP2 | 0.726313 | 4 | 0 | 4 |
| LZTS2 | POLR3C | 0.717369 | 3 | 0 | 3 |
| LZTS2 | LRRC58 | 0.716285 | 3 | 0 | 3 |
| LZTS2 | CRTC2 | 0.711535 | 4 | 0 | 3 |
| LZTS2 | SSBP4 | 0.70678 | 4 | 0 | 4 |
| LZTS2 | CCNT1 | 0.705911 | 3 | 0 | 3 |
| LZTS2 | TBL2 | 0.705393 | 3 | 0 | 3 |
| LZTS2 | UTP23 | 0.702268 | 3 | 0 | 3 |
| LZTS2 | FIBCD1 | 0.693898 | 3 | 0 | 3 |
| LZTS2 | CCNY | 0.692892 | 3 | 0 | 3 |
| LZTS2 | BRD2 | 0.688845 | 3 | 0 | 3 |
| LZTS2 | TMEM150A | 0.687856 | 5 | 0 | 5 |
| LZTS2 | ZNF26 | 0.68758 | 3 | 0 | 3 |
| LZTS2 | ENG | 0.682224 | 4 | 0 | 4 |
| LZTS2 | CBX5 | 0.679808 | 3 | 0 | 3 |
| LZTS2 | PRKRA | 0.677151 | 3 | 0 | 3 |
| LZTS2 | MED22 | 0.676634 | 4 | 0 | 4 |
| LZTS2 | ZNF195 | 0.672952 | 3 | 0 | 3 |
| LZTS2 | PHF2 | 0.672688 | 4 | 0 | 3 |
For details and further investigation, click here
