| Full name: heart and neural crest derivatives expressed 1 | Alias Symbol: eHand|Thing1|Hxt|bHLHa27 | ||
| Type: protein-coding gene | Cytoband: 5q33.2 | ||
| Entrez ID: 9421 | HGNC ID: HGNC:4807 | Ensembl Gene: ENSG00000113196 | OMIM ID: 602406 |
| Drug and gene relationship at DGIdb | |||
Expression of HAND1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HAND1 | 9421 | 220138_at | -0.0103 | 0.9809 | |
| GSE20347 | HAND1 | 9421 | 220138_at | -0.0274 | 0.7853 | |
| GSE23400 | HAND1 | 9421 | 220138_at | -0.2343 | 0.0000 | |
| GSE26886 | HAND1 | 9421 | 220138_at | -0.1483 | 0.2463 | |
| GSE29001 | HAND1 | 9421 | 220138_at | -0.2445 | 0.1876 | |
| GSE38129 | HAND1 | 9421 | 220138_at | -0.1590 | 0.0379 | |
| GSE45670 | HAND1 | 9421 | 220138_at | -0.0242 | 0.8674 | |
| GSE63941 | HAND1 | 9421 | 220138_at | 0.2483 | 0.3649 | |
| GSE77861 | HAND1 | 9421 | 220138_at | -0.1338 | 0.2188 | |
| TCGA | HAND1 | 9421 | RNAseq | 2.3437 | 0.0998 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HAND1 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of HAND1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HAND1 | 9421 | 0 | 12 | 18 | |
| GSE20123 | HAND1 | 9421 | 0 | 12 | 18 | |
| GSE43470 | HAND1 | 9421 | 2 | 10 | 31 | |
| GSE46452 | HAND1 | 9421 | 0 | 27 | 32 | |
| GSE47630 | HAND1 | 9421 | 0 | 20 | 20 | |
| GSE54993 | HAND1 | 9421 | 9 | 1 | 60 | |
| GSE54994 | HAND1 | 9421 | 1 | 16 | 36 | |
| GSE60625 | HAND1 | 9421 | 0 | 0 | 11 | |
| GSE74703 | HAND1 | 9421 | 2 | 8 | 26 | |
| GSE74704 | HAND1 | 9421 | 0 | 7 | 13 | |
| TCGA | HAND1 | 9421 | 6 | 37 | 53 |
Total number of gains: 20; Total number of losses: 150; Total Number of normals: 318.
Somatic mutations of HAND1:
Generating mutation plots.
Highly correlated genes for HAND1:
Showing top 20/1057 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HAND1 | SYT13 | 0.77028 | 3 | 0 | 3 |
| HAND1 | SERPINA5 | 0.744798 | 3 | 0 | 3 |
| HAND1 | LRTM1 | 0.743915 | 4 | 0 | 4 |
| HAND1 | GALNT8 | 0.728334 | 5 | 0 | 5 |
| HAND1 | CHAT | 0.727146 | 4 | 0 | 4 |
| HAND1 | FAM163A | 0.726815 | 5 | 0 | 5 |
| HAND1 | MUC5AC | 0.725332 | 4 | 0 | 4 |
| HAND1 | NMUR2 | 0.724101 | 3 | 0 | 3 |
| HAND1 | G6PC2 | 0.723384 | 7 | 0 | 7 |
| HAND1 | ADAM22 | 0.717645 | 5 | 0 | 5 |
| HAND1 | SIT1 | 0.717319 | 3 | 0 | 3 |
| HAND1 | DSCR4 | 0.71522 | 4 | 0 | 4 |
| HAND1 | KRTAP5-8 | 0.71317 | 6 | 0 | 5 |
| HAND1 | SLC5A5 | 0.710784 | 5 | 0 | 5 |
| HAND1 | AMELY | 0.70633 | 4 | 0 | 4 |
| HAND1 | PRL | 0.703244 | 5 | 0 | 5 |
| HAND1 | ITGB3 | 0.702286 | 5 | 0 | 5 |
| HAND1 | PHLDB1 | 0.702144 | 6 | 0 | 5 |
| HAND1 | LECT2 | 0.701985 | 5 | 0 | 5 |
| HAND1 | RRH | 0.701072 | 4 | 0 | 4 |
For details and further investigation, click here
