| Full name: prion protein | Alias Symbol: CD230|PRP|AltPrP | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 5621 | HGNC ID: HGNC:9449 | Ensembl Gene: ENSG00000171867 | OMIM ID: 176640 |
| Drug and gene relationship at DGIdb | |||
PRNP involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05020 | Prion diseases |
Expression of PRNP:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PRNP | 5621 | 201300_s_at | 0.3465 | 0.6426 | |
| GSE20347 | PRNP | 5621 | 201300_s_at | 0.9762 | 0.0001 | |
| GSE23400 | PRNP | 5621 | 201300_s_at | 0.8237 | 0.0000 | |
| GSE26886 | PRNP | 5621 | 201300_s_at | 1.3298 | 0.0000 | |
| GSE29001 | PRNP | 5621 | 201300_s_at | 0.9452 | 0.0003 | |
| GSE38129 | PRNP | 5621 | 201300_s_at | 0.6986 | 0.0004 | |
| GSE45670 | PRNP | 5621 | 201300_s_at | 0.5990 | 0.0220 | |
| GSE53622 | PRNP | 5621 | 48214 | 1.0967 | 0.0000 | |
| GSE53624 | PRNP | 5621 | 48214 | 1.3364 | 0.0000 | |
| GSE63941 | PRNP | 5621 | 201300_s_at | -1.0956 | 0.0027 | |
| GSE77861 | PRNP | 5621 | 201300_s_at | 1.6222 | 0.0006 | |
| GSE97050 | PRNP | 5621 | A_23_P109143 | 0.4617 | 0.3531 | |
| SRP007169 | PRNP | 5621 | RNAseq | 0.2354 | 0.4592 | |
| SRP008496 | PRNP | 5621 | RNAseq | 1.0635 | 0.0005 | |
| SRP064894 | PRNP | 5621 | RNAseq | 1.2555 | 0.0000 | |
| SRP133303 | PRNP | 5621 | RNAseq | 1.1660 | 0.0000 | |
| SRP159526 | PRNP | 5621 | RNAseq | 0.8151 | 0.0000 | |
| SRP193095 | PRNP | 5621 | RNAseq | 1.2276 | 0.0000 | |
| SRP219564 | PRNP | 5621 | RNAseq | 0.7784 | 0.1617 | |
| TCGA | PRNP | 5621 | RNAseq | 0.2810 | 0.0001 |
Upregulated datasets: 8; Downregulated datasets: 1.
Survival by PRNP expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PRNP:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PRNP | 5621 | 11 | 3 | 16 | |
| GSE20123 | PRNP | 5621 | 12 | 3 | 15 | |
| GSE43470 | PRNP | 5621 | 10 | 1 | 32 | |
| GSE46452 | PRNP | 5621 | 26 | 1 | 32 | |
| GSE47630 | PRNP | 5621 | 18 | 4 | 18 | |
| GSE54993 | PRNP | 5621 | 2 | 14 | 54 | |
| GSE54994 | PRNP | 5621 | 24 | 2 | 27 | |
| GSE60625 | PRNP | 5621 | 0 | 0 | 11 | |
| GSE74703 | PRNP | 5621 | 9 | 1 | 26 | |
| GSE74704 | PRNP | 5621 | 7 | 1 | 12 | |
| TCGA | PRNP | 5621 | 40 | 11 | 45 |
Total number of gains: 159; Total number of losses: 41; Total Number of normals: 288.
Somatic mutations of PRNP:
Generating mutation plots.
Highly correlated genes for PRNP:
Showing top 20/1387 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PRNP | KLHL13 | 0.830774 | 3 | 0 | 3 |
| PRNP | BLOC1S6 | 0.775697 | 3 | 0 | 3 |
| PRNP | C11orf96 | 0.764299 | 3 | 0 | 3 |
| PRNP | FADS1 | 0.760235 | 3 | 0 | 3 |
| PRNP | PLEKHM3 | 0.752716 | 3 | 0 | 3 |
| PRNP | LPCAT1 | 0.7522 | 11 | 0 | 11 |
| PRNP | ENAH | 0.751513 | 12 | 0 | 11 |
| PRNP | ITGAV | 0.748424 | 12 | 0 | 11 |
| PRNP | RILPL1 | 0.747516 | 3 | 0 | 3 |
| PRNP | IRF2BP2 | 0.74303 | 3 | 0 | 3 |
| PRNP | WDR81 | 0.740195 | 3 | 0 | 3 |
| PRNP | MSN | 0.736489 | 12 | 0 | 11 |
| PRNP | OR2T12 | 0.734048 | 3 | 0 | 3 |
| PRNP | FBLIM1 | 0.73288 | 7 | 0 | 6 |
| PRNP | DDX5 | 0.727021 | 3 | 0 | 3 |
| PRNP | FNDC3B | 0.726026 | 11 | 0 | 11 |
| PRNP | GNG10 | 0.725152 | 3 | 0 | 3 |
| PRNP | TGFBI | 0.724149 | 12 | 0 | 11 |
| PRNP | ZFHX3 | 0.719628 | 3 | 0 | 3 |
| PRNP | B3GNT9 | 0.715812 | 8 | 0 | 8 |
For details and further investigation, click here
