| Full name: DEAD-box helicase 5 | Alias Symbol: p68 | ||
| Type: protein-coding gene | Cytoband: 17q23.3 | ||
| Entrez ID: 1655 | HGNC ID: HGNC:2746 | Ensembl Gene: ENSG00000108654 | OMIM ID: 180630 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
DDX5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05205 | Proteoglycans in cancer |
Expression of DDX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DDX5 | 1655 | 225886_at | -0.0454 | 0.9637 | |
| GSE26886 | DDX5 | 1655 | 225886_at | -0.1302 | 0.7270 | |
| GSE45670 | DDX5 | 1655 | 225886_at | -0.3049 | 0.1915 | |
| GSE53622 | DDX5 | 1655 | 30016 | 0.0326 | 0.5571 | |
| GSE53624 | DDX5 | 1655 | 30016 | 0.1338 | 0.0018 | |
| GSE63941 | DDX5 | 1655 | 225886_at | -1.5096 | 0.0076 | |
| GSE77861 | DDX5 | 1655 | 225886_at | 0.7449 | 0.0860 | |
| GSE97050 | DDX5 | 1655 | A_23_P15511 | 0.0726 | 0.8287 | |
| SRP007169 | DDX5 | 1655 | RNAseq | 0.6666 | 0.0904 | |
| SRP008496 | DDX5 | 1655 | RNAseq | 0.6605 | 0.0057 | |
| SRP064894 | DDX5 | 1655 | RNAseq | 0.0186 | 0.9193 | |
| SRP133303 | DDX5 | 1655 | RNAseq | 0.2961 | 0.0707 | |
| SRP159526 | DDX5 | 1655 | RNAseq | -0.0088 | 0.9659 | |
| SRP193095 | DDX5 | 1655 | RNAseq | -0.0328 | 0.6955 | |
| SRP219564 | DDX5 | 1655 | RNAseq | -0.1411 | 0.6351 | |
| TCGA | DDX5 | 1655 | RNAseq | -0.0478 | 0.1792 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by DDX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of DDX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DDX5 | 1655 | 3 | 1 | 26 | |
| GSE20123 | DDX5 | 1655 | 3 | 1 | 26 | |
| GSE43470 | DDX5 | 1655 | 5 | 0 | 38 | |
| GSE46452 | DDX5 | 1655 | 32 | 0 | 27 | |
| GSE47630 | DDX5 | 1655 | 7 | 1 | 32 | |
| GSE54993 | DDX5 | 1655 | 2 | 5 | 63 | |
| GSE54994 | DDX5 | 1655 | 9 | 4 | 40 | |
| GSE60625 | DDX5 | 1655 | 4 | 0 | 7 | |
| GSE74703 | DDX5 | 1655 | 5 | 0 | 31 | |
| GSE74704 | DDX5 | 1655 | 3 | 1 | 16 | |
| TCGA | DDX5 | 1655 | 30 | 8 | 58 |
Total number of gains: 103; Total number of losses: 21; Total Number of normals: 364.
Somatic mutations of DDX5:
Generating mutation plots.
Highly correlated genes for DDX5:
Showing top 20/377 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DDX5 | PRNP | 0.727021 | 3 | 0 | 3 |
| DDX5 | GLYR1 | 0.706413 | 3 | 0 | 3 |
| DDX5 | R3HDM2 | 0.705777 | 4 | 0 | 4 |
| DDX5 | C6orf89 | 0.690623 | 3 | 0 | 3 |
| DDX5 | NHLRC2 | 0.688864 | 5 | 0 | 4 |
| DDX5 | SYNM | 0.686023 | 3 | 0 | 3 |
| DDX5 | ZNF532 | 0.683871 | 3 | 0 | 3 |
| DDX5 | LSM14A | 0.67891 | 4 | 0 | 4 |
| DDX5 | AEBP1 | 0.678396 | 3 | 0 | 3 |
| DDX5 | UBQLN2 | 0.678032 | 3 | 0 | 3 |
| DDX5 | IFT80 | 0.675989 | 3 | 0 | 3 |
| DDX5 | PKIG | 0.6758 | 5 | 0 | 4 |
| DDX5 | ATF2 | 0.674417 | 4 | 0 | 4 |
| DDX5 | POGZ | 0.672687 | 3 | 0 | 3 |
| DDX5 | N4BP2L2 | 0.671827 | 3 | 0 | 3 |
| DDX5 | THAP5 | 0.671699 | 3 | 0 | 3 |
| DDX5 | IGSF11 | 0.671302 | 3 | 0 | 3 |
| DDX5 | CSF1 | 0.667109 | 3 | 0 | 3 |
| DDX5 | WIPF1 | 0.656378 | 5 | 0 | 4 |
| DDX5 | CBY1 | 0.656003 | 3 | 0 | 3 |
For details and further investigation, click here
