| Full name: interferon regulatory factor 2 binding protein 2 | Alias Symbol: IRF-2BP2 | ||
| Type: protein-coding gene | Cytoband: 1q42.3 | ||
| Entrez ID: 359948 | HGNC ID: HGNC:21729 | Ensembl Gene: ENSG00000168264 | OMIM ID: 615332 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of IRF2BP2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IRF2BP2 | 359948 | 224569_s_at | -0.0539 | 0.9098 | |
| GSE26886 | IRF2BP2 | 359948 | 224569_s_at | 0.7976 | 0.0003 | |
| GSE45670 | IRF2BP2 | 359948 | 224569_s_at | -0.1919 | 0.1732 | |
| GSE63941 | IRF2BP2 | 359948 | 224569_s_at | 0.9081 | 0.0197 | |
| GSE77861 | IRF2BP2 | 359948 | 224569_s_at | 0.9664 | 0.0092 | |
| GSE97050 | IRF2BP2 | 359948 | A_24_P497186 | -0.6339 | 0.1204 | |
| SRP007169 | IRF2BP2 | 359948 | RNAseq | -0.1849 | 0.6037 | |
| SRP008496 | IRF2BP2 | 359948 | RNAseq | -0.0969 | 0.6680 | |
| SRP064894 | IRF2BP2 | 359948 | RNAseq | -0.1415 | 0.2720 | |
| SRP133303 | IRF2BP2 | 359948 | RNAseq | -0.1416 | 0.1992 | |
| SRP159526 | IRF2BP2 | 359948 | RNAseq | -0.1222 | 0.7126 | |
| SRP193095 | IRF2BP2 | 359948 | RNAseq | 0.1805 | 0.0719 | |
| SRP219564 | IRF2BP2 | 359948 | RNAseq | 0.0076 | 0.9795 | |
| TCGA | IRF2BP2 | 359948 | RNAseq | 0.0329 | 0.4097 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IRF2BP2 expression:
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| TCGA |
Note: Click image to view full size file.
Copy number change of IRF2BP2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IRF2BP2 | 359948 | 10 | 0 | 20 | |
| GSE20123 | IRF2BP2 | 359948 | 11 | 0 | 19 | |
| GSE43470 | IRF2BP2 | 359948 | 8 | 0 | 35 | |
| GSE46452 | IRF2BP2 | 359948 | 4 | 2 | 53 | |
| GSE47630 | IRF2BP2 | 359948 | 15 | 0 | 25 | |
| GSE54993 | IRF2BP2 | 359948 | 0 | 6 | 64 | |
| GSE54994 | IRF2BP2 | 359948 | 16 | 0 | 37 | |
| GSE60625 | IRF2BP2 | 359948 | 0 | 0 | 11 | |
| GSE74703 | IRF2BP2 | 359948 | 8 | 0 | 28 | |
| GSE74704 | IRF2BP2 | 359948 | 5 | 0 | 15 | |
| TCGA | IRF2BP2 | 359948 | 44 | 3 | 49 |
Total number of gains: 121; Total number of losses: 11; Total Number of normals: 356.
Somatic mutations of IRF2BP2:
Generating mutation plots.
Highly correlated genes for IRF2BP2:
Showing top 20/425 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IRF2BP2 | RBM41 | 0.857402 | 3 | 0 | 3 |
| IRF2BP2 | ANKRD40 | 0.82557 | 3 | 0 | 3 |
| IRF2BP2 | TAF6 | 0.810912 | 3 | 0 | 3 |
| IRF2BP2 | TIPRL | 0.802483 | 3 | 0 | 3 |
| IRF2BP2 | PCDH7 | 0.801396 | 3 | 0 | 3 |
| IRF2BP2 | SFSWAP | 0.794649 | 3 | 0 | 3 |
| IRF2BP2 | SLC39A1 | 0.773998 | 3 | 0 | 3 |
| IRF2BP2 | CKAP5 | 0.770475 | 3 | 0 | 3 |
| IRF2BP2 | GOSR1 | 0.770362 | 3 | 0 | 3 |
| IRF2BP2 | GNS | 0.765457 | 3 | 0 | 3 |
| IRF2BP2 | RSRC1 | 0.75508 | 3 | 0 | 3 |
| IRF2BP2 | GNB5 | 0.753667 | 3 | 0 | 3 |
| IRF2BP2 | HELZ | 0.752662 | 3 | 0 | 3 |
| IRF2BP2 | TRIM47 | 0.752483 | 3 | 0 | 3 |
| IRF2BP2 | RBMX2 | 0.746548 | 3 | 0 | 3 |
| IRF2BP2 | SESTD1 | 0.745704 | 4 | 0 | 3 |
| IRF2BP2 | GLI3 | 0.744381 | 3 | 0 | 3 |
| IRF2BP2 | BRCA1 | 0.744102 | 3 | 0 | 3 |
| IRF2BP2 | ELF4 | 0.743864 | 3 | 0 | 3 |
| IRF2BP2 | ACD | 0.74376 | 3 | 0 | 3 |
For details and further investigation, click here
