| Full name: proteasome assembly chaperone 4 | Alias Symbol: PAC4 | ||
| Type: protein-coding gene | Cytoband: 6p25.2 | ||
| Entrez ID: 389362 | HGNC ID: HGNC:21108 | Ensembl Gene: ENSG00000180822 | OMIM ID: 617550 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of PSMG4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PSMG4 | 389362 | 228217_s_at | 0.4211 | 0.6954 | |
| GSE26886 | PSMG4 | 389362 | 228217_s_at | 1.4841 | 0.0000 | |
| GSE45670 | PSMG4 | 389362 | 228217_s_at | 0.0335 | 0.8765 | |
| GSE53622 | PSMG4 | 389362 | 70242 | -0.1058 | 0.1826 | |
| GSE53624 | PSMG4 | 389362 | 70242 | 0.1970 | 0.0009 | |
| GSE63941 | PSMG4 | 389362 | 228217_s_at | 0.4462 | 0.4304 | |
| GSE77861 | PSMG4 | 389362 | 228217_s_at | -0.2329 | 0.3204 | |
| GSE97050 | PSMG4 | 389362 | A_33_P3259058 | -0.0267 | 0.9366 | |
| SRP007169 | PSMG4 | 389362 | RNAseq | -0.3677 | 0.4183 | |
| SRP008496 | PSMG4 | 389362 | RNAseq | 0.1468 | 0.6573 | |
| SRP064894 | PSMG4 | 389362 | RNAseq | 0.9018 | 0.0185 | |
| SRP133303 | PSMG4 | 389362 | RNAseq | -0.2188 | 0.2198 | |
| SRP159526 | PSMG4 | 389362 | RNAseq | 0.1359 | 0.6300 | |
| SRP193095 | PSMG4 | 389362 | RNAseq | -0.0427 | 0.7481 | |
| SRP219564 | PSMG4 | 389362 | RNAseq | -0.0642 | 0.8733 | |
| TCGA | PSMG4 | 389362 | RNAseq | 0.1029 | 0.3203 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by PSMG4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PSMG4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PSMG4 | 389362 | 4 | 5 | 21 | |
| GSE20123 | PSMG4 | 389362 | 4 | 5 | 21 | |
| GSE43470 | PSMG4 | 389362 | 8 | 2 | 33 | |
| GSE46452 | PSMG4 | 389362 | 1 | 10 | 48 | |
| GSE47630 | PSMG4 | 389362 | 7 | 8 | 25 | |
| GSE54993 | PSMG4 | 389362 | 1 | 1 | 68 | |
| GSE54994 | PSMG4 | 389362 | 10 | 3 | 40 | |
| GSE60625 | PSMG4 | 389362 | 0 | 1 | 10 | |
| GSE74703 | PSMG4 | 389362 | 7 | 2 | 27 | |
| GSE74704 | PSMG4 | 389362 | 2 | 2 | 16 | |
| TCGA | PSMG4 | 389362 | 17 | 30 | 49 |
Total number of gains: 61; Total number of losses: 69; Total Number of normals: 358.
Somatic mutations of PSMG4:
Generating mutation plots.
Highly correlated genes for PSMG4:
Showing top 20/220 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PSMG4 | PARP12 | 0.776536 | 3 | 0 | 3 |
| PSMG4 | TAP1 | 0.738435 | 3 | 0 | 3 |
| PSMG4 | LHX5 | 0.736461 | 3 | 0 | 3 |
| PSMG4 | GTPBP8 | 0.727025 | 3 | 0 | 3 |
| PSMG4 | WDR25 | 0.723894 | 3 | 0 | 3 |
| PSMG4 | ZNF184 | 0.714935 | 3 | 0 | 3 |
| PSMG4 | GUSB | 0.712011 | 3 | 0 | 3 |
| PSMG4 | CEP89 | 0.704543 | 3 | 0 | 3 |
| PSMG4 | ZNF211 | 0.704331 | 3 | 0 | 3 |
| PSMG4 | SLC25A29 | 0.700162 | 3 | 0 | 3 |
| PSMG4 | FIP1L1 | 0.695828 | 3 | 0 | 3 |
| PSMG4 | EXOSC10 | 0.692864 | 4 | 0 | 4 |
| PSMG4 | COQ4 | 0.692716 | 4 | 0 | 4 |
| PSMG4 | UBAP2 | 0.692245 | 3 | 0 | 3 |
| PSMG4 | DERL2 | 0.690719 | 3 | 0 | 3 |
| PSMG4 | PACSIN3 | 0.690619 | 3 | 0 | 3 |
| PSMG4 | NAF1 | 0.686225 | 3 | 0 | 3 |
| PSMG4 | SDAD1 | 0.683212 | 3 | 0 | 3 |
| PSMG4 | C10orf55 | 0.683007 | 3 | 0 | 3 |
| PSMG4 | RPL22L1 | 0.682875 | 3 | 0 | 3 |
For details and further investigation, click here
