PARP12

 

Full name: poly(ADP-ribose) polymerase family member 12 Alias Symbol: FLJ22693|PARP-12|ZC3H1
Type: protein-coding gene Cytoband: 7q34
Entrez ID: 64761 HGNC ID: HGNC:21919 Ensembl Gene: ENSG00000059378 OMIM ID: 612481
Drug and gene relationship at DGIdb

 

Expression of PARP12:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PARP12 64761 218543_s_at 0.7598 0.1168
GSE20347 PARP12 64761 218543_s_at 1.2964 0.0000
GSE23400 PARP12 64761 218543_s_at 1.1519 0.0000
GSE26886 PARP12 64761 218543_s_at 1.2349 0.0000
GSE29001 PARP12 64761 218543_s_at 1.7303 0.0000
GSE38129 PARP12 64761 218543_s_at 1.2015 0.0000
GSE45670 PARP12 64761 218543_s_at 1.6048 0.0000
GSE53622 PARP12 64761 119688 1.0828 0.0000
GSE53624 PARP12 64761 119688 1.3894 0.0000
GSE63941 PARP12 64761 218543_s_at 0.2919 0.6415
GSE77861 PARP12 64761 218543_s_at 1.1189 0.0026
GSE97050 PARP12 64761 A_23_P111804 0.6417 0.1816
SRP007169 PARP12 64761 RNAseq 1.7172 0.0003
SRP008496 PARP12 64761 RNAseq 1.4608 0.0000
SRP064894 PARP12 64761 RNAseq 1.8423 0.0000
SRP133303 PARP12 64761 RNAseq 1.2878 0.0000
SRP159526 PARP12 64761 RNAseq 0.0776 0.7844
SRP193095 PARP12 64761 RNAseq 0.8382 0.0002
SRP219564 PARP12 64761 RNAseq 0.9618 0.0301
TCGA PARP12 64761 RNAseq 0.3137 0.0000

Upregulated datasets: 13; Downregulated datasets: 0.  

 

Survival by PARP12 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PARP12:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PARP12 64761 5 2 23
GSE20123 PARP12 64761 5 2 23
GSE43470 PARP12 64761 2 4 37
GSE46452 PARP12 64761 7 2 50
GSE47630 PARP12 64761 7 4 29
GSE54993 PARP12 64761 3 5 62
GSE54994 PARP12 64761 5 8 40
GSE60625 PARP12 64761 0 0 11
GSE74703 PARP12 64761 2 4 30
GSE74704 PARP12 64761 1 2 17
TCGA PARP12 64761 28 24 44

Total number of gains: 65; Total number of losses: 57; Total Number of normals: 366.  

 

Somatic mutations of PARP12:

 

Generating mutation plots.

 

Highly correlated genes for PARP12:

 

Showing top 20/2074 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PARP12USP410.818683303
PARP12ARPC1B0.78019111011
PARP12PSMG40.776536303
PARP12PARP140.774063909
PARP12SLC39A30.772982404
PARP12ISG150.77243613013
PARP12RILPL20.766199303
PARP12MET0.76507510010
PARP12NUP620.76033911011
PARP12IFITM10.759474908
PARP12ADAR0.75713413011
PARP12DNMT10.75450111011
PARP12IFI60.75325113012
PARP12XPR10.751163606
PARP12LAMP30.74981912011
PARP12IRF90.746997908
PARP12PLAU0.74685911011
PARP12TAP10.74631109
PARP12C12orf750.739258606
PARP12PLA2G70.7379111011

For details and further investigation, click here