| Full name: leucine rich glioma inactivated 1 | Alias Symbol: IB1099|ETL1|EPITEMPIN | ||
| Type: protein-coding gene | Cytoband: 10q23.33 | ||
| Entrez ID: 9211 | HGNC ID: HGNC:6572 | Ensembl Gene: ENSG00000108231 | OMIM ID: 604619 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of LGI1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LGI1 | 9211 | 206349_at | -1.5609 | 0.0132 | |
| GSE20347 | LGI1 | 9211 | 206349_at | -0.1987 | 0.0202 | |
| GSE23400 | LGI1 | 9211 | 206349_at | -0.2562 | 0.0000 | |
| GSE26886 | LGI1 | 9211 | 206349_at | -0.1484 | 0.4388 | |
| GSE29001 | LGI1 | 9211 | 206349_at | -0.2963 | 0.0474 | |
| GSE38129 | LGI1 | 9211 | 206349_at | -0.6593 | 0.0000 | |
| GSE45670 | LGI1 | 9211 | 206349_at | -2.4086 | 0.0000 | |
| GSE53622 | LGI1 | 9211 | 29903 | -3.6734 | 0.0000 | |
| GSE53624 | LGI1 | 9211 | 29903 | -4.4933 | 0.0000 | |
| GSE63941 | LGI1 | 9211 | 206349_at | 0.0640 | 0.6696 | |
| GSE77861 | LGI1 | 9211 | 206349_at | -0.0740 | 0.3791 | |
| SRP064894 | LGI1 | 9211 | RNAseq | -4.5741 | 0.0000 | |
| SRP133303 | LGI1 | 9211 | RNAseq | -5.5248 | 0.0000 | |
| SRP159526 | LGI1 | 9211 | RNAseq | -3.9201 | 0.0000 | |
| TCGA | LGI1 | 9211 | RNAseq | -3.6861 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by LGI1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LGI1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LGI1 | 9211 | 0 | 8 | 22 | |
| GSE20123 | LGI1 | 9211 | 0 | 7 | 23 | |
| GSE43470 | LGI1 | 9211 | 0 | 7 | 36 | |
| GSE46452 | LGI1 | 9211 | 0 | 11 | 48 | |
| GSE47630 | LGI1 | 9211 | 2 | 14 | 24 | |
| GSE54993 | LGI1 | 9211 | 7 | 0 | 63 | |
| GSE54994 | LGI1 | 9211 | 1 | 10 | 42 | |
| GSE60625 | LGI1 | 9211 | 0 | 0 | 11 | |
| GSE74703 | LGI1 | 9211 | 0 | 5 | 31 | |
| GSE74704 | LGI1 | 9211 | 0 | 4 | 16 | |
| TCGA | LGI1 | 9211 | 6 | 26 | 64 |
Total number of gains: 16; Total number of losses: 92; Total Number of normals: 380.
Somatic mutations of LGI1:
Generating mutation plots.
Highly correlated genes for LGI1:
Showing top 20/1285 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LGI1 | LINC01082 | 0.857127 | 4 | 0 | 4 |
| LGI1 | ANGPTL1 | 0.795679 | 5 | 0 | 5 |
| LGI1 | PLCXD3 | 0.790187 | 4 | 0 | 4 |
| LGI1 | RERGL | 0.782736 | 8 | 0 | 8 |
| LGI1 | RSPO1 | 0.781712 | 4 | 0 | 4 |
| LGI1 | NEGR1 | 0.775862 | 5 | 0 | 5 |
| LGI1 | GREM2 | 0.771961 | 9 | 0 | 9 |
| LGI1 | C9orf152 | 0.765159 | 4 | 0 | 4 |
| LGI1 | PTCHD1 | 0.758812 | 4 | 0 | 4 |
| LGI1 | OGN | 0.756851 | 7 | 0 | 6 |
| LGI1 | IP6K3 | 0.749534 | 4 | 0 | 4 |
| LGI1 | IGSF10 | 0.742368 | 4 | 0 | 4 |
| LGI1 | PLAC9 | 0.741715 | 4 | 0 | 4 |
| LGI1 | SCARA5 | 0.737397 | 3 | 0 | 3 |
| LGI1 | SH3BGRL2 | 0.73455 | 5 | 0 | 4 |
| LGI1 | KCNAB1 | 0.734399 | 5 | 0 | 5 |
| LGI1 | MAMDC2 | 0.73294 | 5 | 0 | 5 |
| LGI1 | ZNF662 | 0.732052 | 4 | 0 | 4 |
| LGI1 | F10 | 0.73067 | 7 | 0 | 6 |
| LGI1 | SAMD5 | 0.730533 | 4 | 0 | 4 |
For details and further investigation, click here
