| Full name: purinergic receptor P2X 5 | Alias Symbol: P2X5|LRH-1 | ||
| Type: protein-coding gene | Cytoband: 17p13.2 | ||
| Entrez ID: 5026 | HGNC ID: HGNC:8536 | Ensembl Gene: ENSG00000083454 | OMIM ID: 602836 |
| Drug and gene relationship at DGIdb | |||
P2RX5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway |
Expression of P2RX5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P2RX5 | 5026 | 210448_s_at | 0.0480 | 0.9798 | |
| GSE20347 | P2RX5 | 5026 | 210448_s_at | 0.6296 | 0.0029 | |
| GSE23400 | P2RX5 | 5026 | 210448_s_at | 0.0478 | 0.4909 | |
| GSE26886 | P2RX5 | 5026 | 210448_s_at | 0.8112 | 0.0286 | |
| GSE29001 | P2RX5 | 5026 | 210448_s_at | 0.2242 | 0.2804 | |
| GSE38129 | P2RX5 | 5026 | 210448_s_at | 0.4250 | 0.0862 | |
| GSE45670 | P2RX5 | 5026 | 210448_s_at | 0.4028 | 0.2932 | |
| GSE53622 | P2RX5 | 5026 | 106540 | 0.5376 | 0.0024 | |
| GSE53624 | P2RX5 | 5026 | 106540 | 0.1061 | 0.5290 | |
| GSE63941 | P2RX5 | 5026 | 210448_s_at | 0.1626 | 0.8530 | |
| GSE77861 | P2RX5 | 5026 | 210448_s_at | 0.5255 | 0.4199 | |
| GSE97050 | P2RX5 | 5026 | A_23_P413760 | 1.3588 | 0.2113 | |
| SRP133303 | P2RX5 | 5026 | RNAseq | -0.7873 | 0.1567 | |
| SRP159526 | P2RX5 | 5026 | RNAseq | -1.2593 | 0.2666 | |
| SRP219564 | P2RX5 | 5026 | RNAseq | 1.7737 | 0.0249 | |
| TCGA | P2RX5 | 5026 | RNAseq | 0.1709 | 0.3926 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by P2RX5 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of P2RX5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P2RX5 | 5026 | 5 | 3 | 22 | |
| GSE20123 | P2RX5 | 5026 | 5 | 4 | 21 | |
| GSE43470 | P2RX5 | 5026 | 1 | 6 | 36 | |
| GSE46452 | P2RX5 | 5026 | 34 | 1 | 24 | |
| GSE47630 | P2RX5 | 5026 | 7 | 1 | 32 | |
| GSE54993 | P2RX5 | 5026 | 4 | 3 | 63 | |
| GSE54994 | P2RX5 | 5026 | 5 | 9 | 39 | |
| GSE60625 | P2RX5 | 5026 | 4 | 0 | 7 | |
| GSE74703 | P2RX5 | 5026 | 1 | 3 | 32 | |
| GSE74704 | P2RX5 | 5026 | 3 | 2 | 15 | |
| TCGA | P2RX5 | 5026 | 18 | 21 | 57 |
Total number of gains: 87; Total number of losses: 53; Total Number of normals: 348.
Somatic mutations of P2RX5:
Generating mutation plots.
Highly correlated genes for P2RX5:
Showing top 20/113 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P2RX5 | PTGDS | 0.729707 | 3 | 0 | 3 |
| P2RX5 | PTPRCAP | 0.705227 | 4 | 0 | 3 |
| P2RX5 | PPM1F | 0.669157 | 3 | 0 | 3 |
| P2RX5 | FCRL3 | 0.663427 | 4 | 0 | 4 |
| P2RX5 | FCRL5 | 0.660646 | 5 | 0 | 5 |
| P2RX5 | IL24 | 0.655942 | 4 | 0 | 4 |
| P2RX5 | TRPA1 | 0.648873 | 3 | 0 | 3 |
| P2RX5 | CARD11 | 0.648126 | 4 | 0 | 3 |
| P2RX5 | KIF26B | 0.646442 | 3 | 0 | 3 |
| P2RX5 | CPSF1 | 0.642538 | 3 | 0 | 3 |
| P2RX5 | BCAT1 | 0.639974 | 4 | 0 | 3 |
| P2RX5 | NPM3 | 0.633936 | 4 | 0 | 3 |
| P2RX5 | PIK3CD | 0.629809 | 4 | 0 | 3 |
| P2RX5 | TRABD | 0.628475 | 5 | 0 | 4 |
| P2RX5 | ENTPD1 | 0.623328 | 4 | 0 | 3 |
| P2RX5 | LY86 | 0.620776 | 6 | 0 | 5 |
| P2RX5 | CD72 | 0.615108 | 6 | 0 | 5 |
| P2RX5 | JAK3 | 0.614904 | 4 | 0 | 3 |
| P2RX5 | PIK3AP1 | 0.614566 | 5 | 0 | 4 |
| P2RX5 | CHRNA5 | 0.612226 | 4 | 0 | 3 |
For details and further investigation, click here
