| Full name: actinin alpha 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q24.1 | ||
| Entrez ID: 87 | HGNC ID: HGNC:163 | Ensembl Gene: ENSG00000072110 | OMIM ID: 102575 |
| Drug and gene relationship at DGIdb | |||
ACTN1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04510 | Focal adhesion | |
| hsa04520 | Adherens junction | |
| hsa04530 | Tight junction | |
| hsa04810 | Regulation of actin cytoskeleton |
Expression of ACTN1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ACTN1 | 87 | 208636_at | 0.0399 | 0.9518 | |
| GSE20347 | ACTN1 | 87 | 208636_at | 0.6436 | 0.0089 | |
| GSE23400 | ACTN1 | 87 | 208636_at | 0.4751 | 0.0008 | |
| GSE26886 | ACTN1 | 87 | 208636_at | 1.2405 | 0.0007 | |
| GSE29001 | ACTN1 | 87 | 208636_at | 0.6465 | 0.0160 | |
| GSE38129 | ACTN1 | 87 | 208636_at | 0.4155 | 0.1211 | |
| GSE45670 | ACTN1 | 87 | 208636_at | 0.3014 | 0.4067 | |
| GSE53622 | ACTN1 | 87 | 40139 | 0.3094 | 0.0003 | |
| GSE53624 | ACTN1 | 87 | 40139 | 0.3869 | 0.0000 | |
| GSE63941 | ACTN1 | 87 | 208636_at | -0.7999 | 0.1228 | |
| GSE77861 | ACTN1 | 87 | 208636_at | 0.9351 | 0.1086 | |
| GSE97050 | ACTN1 | 87 | A_23_P105957 | 0.3028 | 0.4015 | |
| SRP007169 | ACTN1 | 87 | RNAseq | 1.3634 | 0.0088 | |
| SRP008496 | ACTN1 | 87 | RNAseq | 1.2365 | 0.0000 | |
| SRP064894 | ACTN1 | 87 | RNAseq | 1.0085 | 0.0000 | |
| SRP133303 | ACTN1 | 87 | RNAseq | 1.1287 | 0.0008 | |
| SRP159526 | ACTN1 | 87 | RNAseq | 0.4519 | 0.3240 | |
| SRP193095 | ACTN1 | 87 | RNAseq | 1.7097 | 0.0000 | |
| SRP219564 | ACTN1 | 87 | RNAseq | 0.1937 | 0.7830 | |
| TCGA | ACTN1 | 87 | RNAseq | 0.0759 | 0.2830 |
Upregulated datasets: 6; Downregulated datasets: 0.
Survival by ACTN1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ACTN1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ACTN1 | 87 | 8 | 2 | 20 | |
| GSE20123 | ACTN1 | 87 | 8 | 2 | 20 | |
| GSE43470 | ACTN1 | 87 | 8 | 3 | 32 | |
| GSE46452 | ACTN1 | 87 | 16 | 3 | 40 | |
| GSE47630 | ACTN1 | 87 | 11 | 9 | 20 | |
| GSE54993 | ACTN1 | 87 | 3 | 9 | 58 | |
| GSE54994 | ACTN1 | 87 | 18 | 5 | 30 | |
| GSE60625 | ACTN1 | 87 | 0 | 2 | 9 | |
| GSE74703 | ACTN1 | 87 | 7 | 3 | 26 | |
| GSE74704 | ACTN1 | 87 | 3 | 2 | 15 | |
| TCGA | ACTN1 | 87 | 32 | 16 | 48 |
Total number of gains: 114; Total number of losses: 56; Total Number of normals: 318.
Somatic mutations of ACTN1:
Generating mutation plots.
Highly correlated genes for ACTN1:
Showing top 20/1187 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ACTN1 | PTP4A3 | 0.724724 | 5 | 0 | 5 |
| ACTN1 | SNTA1 | 0.724559 | 4 | 0 | 4 |
| ACTN1 | UAP1 | 0.723165 | 3 | 0 | 3 |
| ACTN1 | CD276 | 0.722869 | 3 | 0 | 3 |
| ACTN1 | MICAL2 | 0.72098 | 10 | 0 | 9 |
| ACTN1 | RAMP1 | 0.709371 | 5 | 0 | 4 |
| ACTN1 | SLC6A6 | 0.705545 | 3 | 0 | 3 |
| ACTN1 | LGALS1 | 0.705037 | 13 | 0 | 12 |
| ACTN1 | C20orf194 | 0.702221 | 4 | 0 | 4 |
| ACTN1 | INHBA | 0.701368 | 12 | 0 | 11 |
| ACTN1 | DOK1 | 0.696376 | 3 | 0 | 3 |
| ACTN1 | MNT | 0.693265 | 3 | 0 | 3 |
| ACTN1 | FILIP1 | 0.688709 | 3 | 0 | 3 |
| ACTN1 | TTC7B | 0.687701 | 7 | 0 | 5 |
| ACTN1 | CAV1 | 0.687234 | 13 | 0 | 11 |
| ACTN1 | COL4A2 | 0.68679 | 12 | 0 | 12 |
| ACTN1 | FGFRL1 | 0.686568 | 3 | 0 | 3 |
| ACTN1 | KLF7 | 0.685627 | 12 | 0 | 11 |
| ACTN1 | CDC42EP3 | 0.685409 | 11 | 0 | 9 |
| ACTN1 | MCAM | 0.682983 | 10 | 0 | 9 |
For details and further investigation, click here
