PTPDC1

 

Full name: protein tyrosine phosphatase domain containing 1 Alias Symbol: PTP9Q22|FLJ37312
Type: protein-coding gene Cytoband: 9q22.32
Entrez ID: 138639 HGNC ID: HGNC:30184 Ensembl Gene: ENSG00000158079 OMIM ID: 
Drug and gene relationship at DGIdb
Screen Evidence:
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of PTPDC1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PTPDC1 138639 229517_at 0.1271 0.8657
GSE26886 PTPDC1 138639 229517_at 1.1181 0.0001
GSE45670 PTPDC1 138639 229517_at 0.4581 0.0329
GSE53622 PTPDC1 138639 24591 0.5628 0.0000
GSE53624 PTPDC1 138639 24591 1.0264 0.0000
GSE63941 PTPDC1 138639 229517_at 0.7604 0.1657
GSE77861 PTPDC1 138639 229517_at 0.2587 0.0690
GSE97050 PTPDC1 138639 A_23_P20876 -0.0956 0.7578
SRP007169 PTPDC1 138639 RNAseq 2.6966 0.0000
SRP008496 PTPDC1 138639 RNAseq 2.0061 0.0000
SRP064894 PTPDC1 138639 RNAseq 1.3450 0.0000
SRP133303 PTPDC1 138639 RNAseq 1.0812 0.0000
SRP159526 PTPDC1 138639 RNAseq 1.1751 0.0049
SRP193095 PTPDC1 138639 RNAseq 0.7239 0.0000
SRP219564 PTPDC1 138639 RNAseq 0.7498 0.0828
TCGA PTPDC1 138639 RNAseq -0.1376 0.0970

Upregulated datasets: 7; Downregulated datasets: 0.  

 

Survival by PTPDC1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PTPDC1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PTPDC1 138639 5 9 16
GSE20123 PTPDC1 138639 5 9 16
GSE43470 PTPDC1 138639 6 3 34
GSE46452 PTPDC1 138639 6 14 39
GSE47630 PTPDC1 138639 1 17 22
GSE54993 PTPDC1 138639 4 2 64
GSE54994 PTPDC1 138639 8 11 34
GSE60625 PTPDC1 138639 0 0 11
GSE74703 PTPDC1 138639 5 3 28
GSE74704 PTPDC1 138639 2 7 11
TCGA PTPDC1 138639 24 23 49

Total number of gains: 66; Total number of losses: 98; Total Number of normals: 324.  

 

Somatic mutations of PTPDC1:

 

Generating mutation plots.

 

Highly correlated genes for PTPDC1:

 

Showing top 20/751 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PTPDC1ARMC90.722589303
PTPDC1TRAF50.698467404
PTPDC1ITIH60.689369303
PTPDC1PDE9A0.688199303
PTPDC1CEP1120.688054303
PTPDC1FCGR2A0.687201303
PTPDC1MICAL20.685397303
PTPDC1MXRA70.685207404
PTPDC1EME10.684375303
PTPDC1TUBE10.680593303
PTPDC1RASD20.678492403
PTPDC1ITPK10.672431403
PTPDC1INPP4A0.671964606
PTPDC1DNAJC180.667363303
PTPDC1HS1BP30.667231504
PTPDC1DPY19L20.666808303
PTPDC1EIF5A20.663712706
PTPDC1MIPOL10.663622303
PTPDC1HABP40.659284403
PTPDC1SDR39U10.654646303

For details and further investigation, click here