| Full name: inositol-tetrakisphosphate 1-kinase | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 14q32.12 | ||
| Entrez ID: 3705 | HGNC ID: HGNC:6177 | Ensembl Gene: ENSG00000100605 | OMIM ID: 601838 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of ITPK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ITPK1 | 3705 | 210740_s_at | -0.0019 | 0.9984 | |
| GSE20347 | ITPK1 | 3705 | 210740_s_at | 0.3104 | 0.0413 | |
| GSE23400 | ITPK1 | 3705 | 210740_s_at | 0.0382 | 0.6193 | |
| GSE26886 | ITPK1 | 3705 | 210740_s_at | 1.2872 | 0.0000 | |
| GSE29001 | ITPK1 | 3705 | 210740_s_at | 0.6366 | 0.0415 | |
| GSE38129 | ITPK1 | 3705 | 210740_s_at | -0.0193 | 0.9353 | |
| GSE45670 | ITPK1 | 3705 | 210740_s_at | -0.1246 | 0.5088 | |
| GSE53622 | ITPK1 | 3705 | 25546 | 0.0615 | 0.6004 | |
| GSE53624 | ITPK1 | 3705 | 25546 | 0.3934 | 0.0000 | |
| GSE63941 | ITPK1 | 3705 | 210740_s_at | 0.6006 | 0.0437 | |
| GSE77861 | ITPK1 | 3705 | 210740_s_at | 0.3157 | 0.2256 | |
| GSE97050 | ITPK1 | 3705 | A_24_P167683 | -0.1924 | 0.5671 | |
| SRP007169 | ITPK1 | 3705 | RNAseq | 0.3387 | 0.3223 | |
| SRP008496 | ITPK1 | 3705 | RNAseq | 0.7568 | 0.0006 | |
| SRP064894 | ITPK1 | 3705 | RNAseq | 0.2963 | 0.2047 | |
| SRP133303 | ITPK1 | 3705 | RNAseq | 0.2174 | 0.3006 | |
| SRP159526 | ITPK1 | 3705 | RNAseq | -0.1739 | 0.5113 | |
| SRP193095 | ITPK1 | 3705 | RNAseq | 0.3206 | 0.1852 | |
| SRP219564 | ITPK1 | 3705 | RNAseq | -0.0750 | 0.8973 | |
| TCGA | ITPK1 | 3705 | RNAseq | -0.1485 | 0.0075 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by ITPK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ITPK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ITPK1 | 3705 | 8 | 5 | 17 | |
| GSE20123 | ITPK1 | 3705 | 8 | 4 | 18 | |
| GSE43470 | ITPK1 | 3705 | 7 | 3 | 33 | |
| GSE46452 | ITPK1 | 3705 | 16 | 3 | 40 | |
| GSE47630 | ITPK1 | 3705 | 11 | 8 | 21 | |
| GSE54993 | ITPK1 | 3705 | 3 | 8 | 59 | |
| GSE54994 | ITPK1 | 3705 | 20 | 4 | 29 | |
| GSE60625 | ITPK1 | 3705 | 0 | 2 | 9 | |
| GSE74703 | ITPK1 | 3705 | 6 | 3 | 27 | |
| GSE74704 | ITPK1 | 3705 | 4 | 3 | 13 | |
| TCGA | ITPK1 | 3705 | 29 | 21 | 46 |
Total number of gains: 112; Total number of losses: 64; Total Number of normals: 312.
Somatic mutations of ITPK1:
Generating mutation plots.
Highly correlated genes for ITPK1:
Showing top 20/1031 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ITPK1 | KRTCAP2 | 0.796865 | 3 | 0 | 3 |
| ITPK1 | ZNF319 | 0.787749 | 3 | 0 | 3 |
| ITPK1 | CYP27C1 | 0.779107 | 3 | 0 | 3 |
| ITPK1 | CRHBP | 0.768738 | 3 | 0 | 3 |
| ITPK1 | KCNAB2 | 0.766092 | 3 | 0 | 3 |
| ITPK1 | MYEF2 | 0.761132 | 3 | 0 | 3 |
| ITPK1 | SZT2 | 0.744991 | 3 | 0 | 3 |
| ITPK1 | PGRMC1 | 0.740367 | 3 | 0 | 3 |
| ITPK1 | LBR | 0.737055 | 3 | 0 | 3 |
| ITPK1 | WDR66 | 0.725088 | 3 | 0 | 3 |
| ITPK1 | C15orf61 | 0.722087 | 3 | 0 | 3 |
| ITPK1 | ZSCAN21 | 0.721082 | 3 | 0 | 3 |
| ITPK1 | FCHO1 | 0.716991 | 3 | 0 | 3 |
| ITPK1 | SMARCD1 | 0.714719 | 5 | 0 | 5 |
| ITPK1 | U2SURP | 0.714489 | 3 | 0 | 3 |
| ITPK1 | SERPINF2 | 0.711348 | 3 | 0 | 3 |
| ITPK1 | NASP | 0.710833 | 4 | 0 | 4 |
| ITPK1 | STRADA | 0.703894 | 3 | 0 | 3 |
| ITPK1 | TTC8 | 0.703533 | 4 | 0 | 3 |
| ITPK1 | TP53I13 | 0.703461 | 4 | 0 | 4 |
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