| Full name: Fc fragment of IgG receptor IIa | Alias Symbol: CD32|CD32A|IGFR2|CDw32 | ||
| Type: protein-coding gene | Cytoband: 1q23.3 | ||
| Entrez ID: 2212 | HGNC ID: HGNC:3616 | Ensembl Gene: ENSG00000143226 | OMIM ID: 146790 |
| Drug and gene relationship at DGIdb | |||
FCGR2A involved pathways:
Expression of FCGR2A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | FCGR2A | 2212 | 203561_at | 0.7892 | 0.5875 | |
| GSE20347 | FCGR2A | 2212 | 203561_at | 0.7324 | 0.0053 | |
| GSE23400 | FCGR2A | 2212 | 203561_at | 0.4046 | 0.0000 | |
| GSE26886 | FCGR2A | 2212 | 203561_at | 0.5418 | 0.0365 | |
| GSE29001 | FCGR2A | 2212 | 203561_at | 0.5231 | 0.0142 | |
| GSE38129 | FCGR2A | 2212 | 203561_at | 0.9273 | 0.0011 | |
| GSE45670 | FCGR2A | 2212 | 203561_at | 0.1778 | 0.7335 | |
| GSE53622 | FCGR2A | 2212 | 125143 | 1.8582 | 0.0000 | |
| GSE53624 | FCGR2A | 2212 | 125143 | 1.7193 | 0.0000 | |
| GSE63941 | FCGR2A | 2212 | 203561_at | -0.4978 | 0.0004 | |
| GSE77861 | FCGR2A | 2212 | 203561_at | 0.3888 | 0.0905 | |
| GSE97050 | FCGR2A | 2212 | A_23_P85716 | 1.8075 | 0.0454 | |
| SRP007169 | FCGR2A | 2212 | RNAseq | 3.2005 | 0.0000 | |
| SRP008496 | FCGR2A | 2212 | RNAseq | 2.9870 | 0.0000 | |
| SRP064894 | FCGR2A | 2212 | RNAseq | 1.8235 | 0.0000 | |
| SRP133303 | FCGR2A | 2212 | RNAseq | 1.9337 | 0.0000 | |
| SRP159526 | FCGR2A | 2212 | RNAseq | 1.6645 | 0.0011 | |
| SRP193095 | FCGR2A | 2212 | RNAseq | 2.6233 | 0.0000 | |
| SRP219564 | FCGR2A | 2212 | RNAseq | 2.2686 | 0.0028 | |
| TCGA | FCGR2A | 2212 | RNAseq | 0.5218 | 0.0000 |
Upregulated datasets: 10; Downregulated datasets: 0.
Survival by FCGR2A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of FCGR2A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | FCGR2A | 2212 | 10 | 0 | 20 | |
| GSE20123 | FCGR2A | 2212 | 10 | 0 | 20 | |
| GSE43470 | FCGR2A | 2212 | 7 | 2 | 34 | |
| GSE46452 | FCGR2A | 2212 | 2 | 1 | 56 | |
| GSE47630 | FCGR2A | 2212 | 14 | 0 | 26 | |
| GSE54993 | FCGR2A | 2212 | 0 | 5 | 65 | |
| GSE54994 | FCGR2A | 2212 | 16 | 0 | 37 | |
| GSE60625 | FCGR2A | 2212 | 0 | 0 | 11 | |
| GSE74703 | FCGR2A | 2212 | 7 | 2 | 27 | |
| GSE74704 | FCGR2A | 2212 | 4 | 0 | 16 | |
| TCGA | FCGR2A | 2212 | 43 | 4 | 49 |
Total number of gains: 113; Total number of losses: 14; Total Number of normals: 361.
Somatic mutations of FCGR2A:
Generating mutation plots.
Highly correlated genes for FCGR2A:
Showing top 20/1028 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| FCGR2A | FCER1G | 0.794402 | 11 | 0 | 11 |
| FCGR2A | CD14 | 0.79354 | 12 | 0 | 12 |
| FCGR2A | CD163 | 0.765519 | 12 | 0 | 11 |
| FCGR2A | FCGR3A | 0.765413 | 3 | 0 | 3 |
| FCGR2A | PDIA5 | 0.756748 | 3 | 0 | 3 |
| FCGR2A | TYROBP | 0.748848 | 12 | 0 | 12 |
| FCGR2A | PYCR2 | 0.748608 | 3 | 0 | 3 |
| FCGR2A | CMTM3 | 0.735698 | 7 | 0 | 6 |
| FCGR2A | SPON2 | 0.733668 | 3 | 0 | 3 |
| FCGR2A | C1QB | 0.731906 | 12 | 0 | 12 |
| FCGR2A | SNAP47 | 0.731083 | 3 | 0 | 3 |
| FCGR2A | C5AR1 | 0.720265 | 12 | 0 | 12 |
| FCGR2A | OLFML2B | 0.715028 | 12 | 0 | 12 |
| FCGR2A | PLA2G7 | 0.713531 | 12 | 0 | 12 |
| FCGR2A | CHRNA1 | 0.712525 | 3 | 0 | 3 |
| FCGR2A | PLEK | 0.707406 | 4 | 0 | 4 |
| FCGR2A | FCGR3B | 0.707075 | 8 | 0 | 7 |
| FCGR2A | LCK | 0.706858 | 3 | 0 | 3 |
| FCGR2A | C3AR1 | 0.703002 | 12 | 0 | 10 |
| FCGR2A | TNFAIP6 | 0.699075 | 13 | 0 | 11 |
For details and further investigation, click here
