| Full name: eukaryotic translation initiation factor 2 alpha kinase 4 | Alias Symbol: GCN2|KIAA1338 | ||
| Type: protein-coding gene | Cytoband: 15q15.1 | ||
| Entrez ID: 440275 | HGNC ID: HGNC:19687 | Ensembl Gene: ENSG00000128829 | OMIM ID: 609280 |
| Drug and gene relationship at DGIdb | |||
EIF2AK4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05160 | Hepatitis C | |
| hsa05162 | Measles | |
| hsa05164 | Influenza A | |
| hsa05168 | Herpes simplex infection |
Expression of EIF2AK4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | EIF2AK4 | 440275 | 225164_s_at | 0.3962 | 0.4819 | |
| GSE26886 | EIF2AK4 | 440275 | 225164_s_at | 0.5586 | 0.0445 | |
| GSE45670 | EIF2AK4 | 440275 | 225164_s_at | 0.1677 | 0.3822 | |
| GSE53622 | EIF2AK4 | 440275 | 38424 | 0.2713 | 0.0000 | |
| GSE53624 | EIF2AK4 | 440275 | 38424 | 0.2749 | 0.0001 | |
| GSE63941 | EIF2AK4 | 440275 | 225164_s_at | -1.1474 | 0.0122 | |
| GSE77861 | EIF2AK4 | 440275 | 225164_s_at | 0.4564 | 0.1723 | |
| GSE97050 | EIF2AK4 | 440275 | A_23_P54540 | -0.0312 | 0.8925 | |
| SRP007169 | EIF2AK4 | 440275 | RNAseq | 0.5858 | 0.1476 | |
| SRP008496 | EIF2AK4 | 440275 | RNAseq | 1.0114 | 0.0016 | |
| SRP064894 | EIF2AK4 | 440275 | RNAseq | 0.2129 | 0.1302 | |
| SRP133303 | EIF2AK4 | 440275 | RNAseq | 0.2433 | 0.0711 | |
| SRP159526 | EIF2AK4 | 440275 | RNAseq | 0.6246 | 0.0729 | |
| SRP193095 | EIF2AK4 | 440275 | RNAseq | 0.3822 | 0.0002 | |
| SRP219564 | EIF2AK4 | 440275 | RNAseq | 0.2814 | 0.2781 | |
| TCGA | EIF2AK4 | 440275 | RNAseq | 0.0706 | 0.1310 |
Upregulated datasets: 1; Downregulated datasets: 1.
Survival by EIF2AK4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of EIF2AK4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | EIF2AK4 | 440275 | 4 | 5 | 21 | |
| GSE20123 | EIF2AK4 | 440275 | 4 | 6 | 20 | |
| GSE43470 | EIF2AK4 | 440275 | 4 | 6 | 33 | |
| GSE46452 | EIF2AK4 | 440275 | 3 | 7 | 49 | |
| GSE47630 | EIF2AK4 | 440275 | 8 | 11 | 21 | |
| GSE54993 | EIF2AK4 | 440275 | 4 | 6 | 60 | |
| GSE54994 | EIF2AK4 | 440275 | 5 | 7 | 41 | |
| GSE60625 | EIF2AK4 | 440275 | 4 | 0 | 7 | |
| GSE74703 | EIF2AK4 | 440275 | 4 | 5 | 27 | |
| GSE74704 | EIF2AK4 | 440275 | 2 | 3 | 15 | |
| TCGA | EIF2AK4 | 440275 | 12 | 16 | 68 |
Total number of gains: 54; Total number of losses: 72; Total Number of normals: 362.
Somatic mutations of EIF2AK4:
Generating mutation plots.
Highly correlated genes for EIF2AK4:
Showing top 20/389 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| EIF2AK4 | ANKS6 | 0.826217 | 3 | 0 | 3 |
| EIF2AK4 | GSR | 0.781304 | 3 | 0 | 3 |
| EIF2AK4 | TPMT | 0.778055 | 3 | 0 | 3 |
| EIF2AK4 | ASCC3 | 0.761758 | 3 | 0 | 3 |
| EIF2AK4 | PTPN4 | 0.761508 | 3 | 0 | 3 |
| EIF2AK4 | FRS2 | 0.76114 | 3 | 0 | 3 |
| EIF2AK4 | GDPD1 | 0.757638 | 4 | 0 | 4 |
| EIF2AK4 | TFIP11 | 0.734725 | 3 | 0 | 3 |
| EIF2AK4 | POLG | 0.733429 | 3 | 0 | 3 |
| EIF2AK4 | TPCN2 | 0.728065 | 3 | 0 | 3 |
| EIF2AK4 | NLK | 0.727355 | 3 | 0 | 3 |
| EIF2AK4 | RGL1 | 0.727222 | 3 | 0 | 3 |
| EIF2AK4 | LBR | 0.726253 | 3 | 0 | 3 |
| EIF2AK4 | SLCO3A1 | 0.725924 | 4 | 0 | 3 |
| EIF2AK4 | ANGEL2 | 0.725713 | 4 | 0 | 3 |
| EIF2AK4 | TTC30B | 0.725274 | 4 | 0 | 3 |
| EIF2AK4 | KCTD7 | 0.721873 | 3 | 0 | 3 |
| EIF2AK4 | SLC25A38 | 0.719073 | 4 | 0 | 4 |
| EIF2AK4 | WSB2 | 0.716634 | 3 | 0 | 3 |
| EIF2AK4 | AGT | 0.714603 | 3 | 0 | 3 |
For details and further investigation, click here
