| Full name: POU class 2 homeobox associating factor 1 | Alias Symbol: OBF1|BOB1 | ||
| Type: protein-coding gene | Cytoband: 11q23.1 | ||
| Entrez ID: 5450 | HGNC ID: HGNC:9211 | Ensembl Gene: ENSG00000110777 | OMIM ID: 601206 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
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Expression of POU2AF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | POU2AF1 | 5450 | 28531 | 0.4260 | 0.1927 | |
| GSE53624 | POU2AF1 | 5450 | 28531 | -0.3728 | 0.1469 | |
| GSE97050 | POU2AF1 | 5450 | A_23_P312920 | 1.3229 | 0.1623 | |
| SRP007169 | POU2AF1 | 5450 | RNAseq | 1.3971 | 0.1228 | |
| SRP064894 | POU2AF1 | 5450 | RNAseq | 0.3092 | 0.4104 | |
| SRP133303 | POU2AF1 | 5450 | RNAseq | 0.0242 | 0.9309 | |
| SRP159526 | POU2AF1 | 5450 | RNAseq | 0.1598 | 0.8683 | |
| SRP193095 | POU2AF1 | 5450 | RNAseq | 0.1362 | 0.6225 | |
| SRP219564 | POU2AF1 | 5450 | RNAseq | 0.3046 | 0.5975 | |
| TCGA | POU2AF1 | 5450 | RNAseq | -0.5725 | 0.0312 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by POU2AF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of POU2AF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | POU2AF1 | 5450 | 0 | 12 | 18 | |
| GSE20123 | POU2AF1 | 5450 | 0 | 12 | 18 | |
| GSE43470 | POU2AF1 | 5450 | 2 | 6 | 35 | |
| GSE46452 | POU2AF1 | 5450 | 3 | 26 | 30 | |
| GSE47630 | POU2AF1 | 5450 | 2 | 19 | 19 | |
| GSE54993 | POU2AF1 | 5450 | 10 | 0 | 60 | |
| GSE54994 | POU2AF1 | 5450 | 5 | 19 | 29 | |
| GSE60625 | POU2AF1 | 5450 | 0 | 3 | 8 | |
| GSE74703 | POU2AF1 | 5450 | 1 | 4 | 31 | |
| GSE74704 | POU2AF1 | 5450 | 0 | 8 | 12 | |
| TCGA | POU2AF1 | 5450 | 6 | 47 | 43 |
Total number of gains: 29; Total number of losses: 156; Total Number of normals: 303.
Somatic mutations of POU2AF1:
Generating mutation plots.
Highly correlated genes for POU2AF1:
Showing top 20/105 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| POU2AF1 | KCNA3 | 0.84627 | 3 | 0 | 3 |
| POU2AF1 | TNFRSF17 | 0.782425 | 4 | 0 | 4 |
| POU2AF1 | CD79B | 0.766186 | 3 | 0 | 3 |
| POU2AF1 | RHOH | 0.764648 | 3 | 0 | 3 |
| POU2AF1 | CD79A | 0.762582 | 4 | 0 | 4 |
| POU2AF1 | EAF2 | 0.759019 | 3 | 0 | 3 |
| POU2AF1 | SLAMF6 | 0.755292 | 4 | 0 | 4 |
| POU2AF1 | IL2RG | 0.751382 | 3 | 0 | 3 |
| POU2AF1 | SEL1L3 | 0.750377 | 3 | 0 | 3 |
| POU2AF1 | IKZF3 | 0.745601 | 3 | 0 | 3 |
| POU2AF1 | STAP1 | 0.73599 | 4 | 0 | 4 |
| POU2AF1 | LCK | 0.735735 | 3 | 0 | 3 |
| POU2AF1 | IRF4 | 0.734982 | 4 | 0 | 3 |
| POU2AF1 | P2RY10 | 0.733494 | 4 | 0 | 4 |
| POU2AF1 | ZAP70 | 0.730678 | 3 | 0 | 3 |
| POU2AF1 | LAX1 | 0.727745 | 4 | 0 | 4 |
| POU2AF1 | CD180 | 0.727268 | 3 | 0 | 3 |
| POU2AF1 | FCRL3 | 0.727119 | 4 | 0 | 4 |
| POU2AF1 | FCRL5 | 0.724485 | 4 | 0 | 4 |
| POU2AF1 | PTPN7 | 0.721822 | 3 | 0 | 3 |
For details and further investigation, click here
