| Full name: pumilio RNA binding family member 2 | Alias Symbol: PUMH2|KIAA0235 | ||
| Type: protein-coding gene | Cytoband: 2p24.1 | ||
| Entrez ID: 23369 | HGNC ID: HGNC:14958 | Ensembl Gene: ENSG00000055917 | OMIM ID: 607205 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of PUM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PUM2 | 23369 | 216221_s_at | -0.3056 | 0.4448 | |
| GSE20347 | PUM2 | 23369 | 201493_s_at | 0.0853 | 0.5976 | |
| GSE23400 | PUM2 | 23369 | 216221_s_at | -0.0872 | 0.1612 | |
| GSE26886 | PUM2 | 23369 | 216221_s_at | -0.3635 | 0.0486 | |
| GSE29001 | PUM2 | 23369 | 216221_s_at | -0.1660 | 0.3988 | |
| GSE38129 | PUM2 | 23369 | 201493_s_at | 0.1361 | 0.3398 | |
| GSE45670 | PUM2 | 23369 | 201493_s_at | 0.0104 | 0.9448 | |
| GSE53622 | PUM2 | 23369 | 70107 | 0.0810 | 0.2504 | |
| GSE53624 | PUM2 | 23369 | 70107 | 0.0811 | 0.1665 | |
| GSE63941 | PUM2 | 23369 | 201493_s_at | 0.5158 | 0.1739 | |
| GSE77861 | PUM2 | 23369 | 201493_s_at | 0.1936 | 0.4959 | |
| GSE97050 | PUM2 | 23369 | A_24_P71439 | -0.1632 | 0.5920 | |
| SRP007169 | PUM2 | 23369 | RNAseq | -0.1527 | 0.6209 | |
| SRP008496 | PUM2 | 23369 | RNAseq | 0.0690 | 0.7084 | |
| SRP064894 | PUM2 | 23369 | RNAseq | -0.3135 | 0.0576 | |
| SRP133303 | PUM2 | 23369 | RNAseq | -0.0178 | 0.8737 | |
| SRP159526 | PUM2 | 23369 | RNAseq | 0.1324 | 0.5987 | |
| SRP193095 | PUM2 | 23369 | RNAseq | -0.2700 | 0.0030 | |
| SRP219564 | PUM2 | 23369 | RNAseq | 0.0049 | 0.9859 | |
| TCGA | PUM2 | 23369 | RNAseq | -0.0239 | 0.5482 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PUM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PUM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PUM2 | 23369 | 10 | 2 | 18 | |
| GSE20123 | PUM2 | 23369 | 10 | 2 | 18 | |
| GSE43470 | PUM2 | 23369 | 2 | 0 | 41 | |
| GSE46452 | PUM2 | 23369 | 3 | 4 | 52 | |
| GSE47630 | PUM2 | 23369 | 7 | 0 | 33 | |
| GSE54993 | PUM2 | 23369 | 0 | 7 | 63 | |
| GSE54994 | PUM2 | 23369 | 11 | 0 | 42 | |
| GSE60625 | PUM2 | 23369 | 0 | 3 | 8 | |
| GSE74703 | PUM2 | 23369 | 2 | 0 | 34 | |
| GSE74704 | PUM2 | 23369 | 8 | 2 | 10 | |
| TCGA | PUM2 | 23369 | 36 | 2 | 58 |
Total number of gains: 89; Total number of losses: 22; Total Number of normals: 377.
Somatic mutations of PUM2:
Generating mutation plots.
Highly correlated genes for PUM2:
Showing top 20/325 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PUM2 | SENP8 | 0.826606 | 3 | 0 | 3 |
| PUM2 | RSL24D1 | 0.818806 | 3 | 0 | 3 |
| PUM2 | VDAC2 | 0.762562 | 3 | 0 | 3 |
| PUM2 | ATF1 | 0.75539 | 3 | 0 | 3 |
| PUM2 | AGGF1 | 0.736562 | 3 | 0 | 3 |
| PUM2 | GABRA3 | 0.722715 | 3 | 0 | 3 |
| PUM2 | TMEM150C | 0.72268 | 3 | 0 | 3 |
| PUM2 | KLHL15 | 0.720189 | 3 | 0 | 3 |
| PUM2 | ARL6 | 0.716091 | 3 | 0 | 3 |
| PUM2 | UNC5CL | 0.712386 | 3 | 0 | 3 |
| PUM2 | ZNF546 | 0.708369 | 3 | 0 | 3 |
| PUM2 | TMBIM4 | 0.705576 | 3 | 0 | 3 |
| PUM2 | ZMYM4 | 0.700635 | 4 | 0 | 3 |
| PUM2 | MFN1 | 0.700571 | 5 | 0 | 4 |
| PUM2 | MRPS11 | 0.699655 | 3 | 0 | 3 |
| PUM2 | ORAI3 | 0.699288 | 3 | 0 | 3 |
| PUM2 | TMEM167B | 0.698116 | 4 | 0 | 3 |
| PUM2 | RNF185 | 0.695802 | 4 | 0 | 4 |
| PUM2 | GTF3C2 | 0.693212 | 5 | 0 | 5 |
| PUM2 | MGST2 | 0.691903 | 3 | 0 | 3 |
For details and further investigation, click here
