| Full name: microsomal glutathione S-transferase 2 | Alias Symbol: MGST-II | ||
| Type: protein-coding gene | Cytoband: 4q31.1 | ||
| Entrez ID: 4258 | HGNC ID: HGNC:7063 | Ensembl Gene: ENSG00000085871 | OMIM ID: 601733 |
| Drug and gene relationship at DGIdb | |||
Expression of MGST2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MGST2 | 4258 | 204168_at | -1.2425 | 0.0298 | |
| GSE20347 | MGST2 | 4258 | 204168_at | -1.5641 | 0.0000 | |
| GSE23400 | MGST2 | 4258 | 204168_at | -1.0492 | 0.0000 | |
| GSE26886 | MGST2 | 4258 | 204168_at | -1.8709 | 0.0000 | |
| GSE29001 | MGST2 | 4258 | 204168_at | -1.3750 | 0.0000 | |
| GSE38129 | MGST2 | 4258 | 204168_at | -1.1067 | 0.0000 | |
| GSE45670 | MGST2 | 4258 | 204168_at | -0.7628 | 0.0040 | |
| GSE53622 | MGST2 | 4258 | 33666 | -1.4768 | 0.0000 | |
| GSE53624 | MGST2 | 4258 | 33666 | -1.5144 | 0.0000 | |
| GSE63941 | MGST2 | 4258 | 204168_at | 0.3054 | 0.7646 | |
| GSE77861 | MGST2 | 4258 | 204168_at | -1.3943 | 0.0006 | |
| GSE97050 | MGST2 | 4258 | A_23_P110167 | -0.7426 | 0.1235 | |
| SRP007169 | MGST2 | 4258 | RNAseq | -2.5936 | 0.0000 | |
| SRP008496 | MGST2 | 4258 | RNAseq | -2.2293 | 0.0000 | |
| SRP064894 | MGST2 | 4258 | RNAseq | -1.4055 | 0.0000 | |
| SRP133303 | MGST2 | 4258 | RNAseq | -1.6347 | 0.0000 | |
| SRP159526 | MGST2 | 4258 | RNAseq | -1.9073 | 0.0021 | |
| SRP193095 | MGST2 | 4258 | RNAseq | -1.8919 | 0.0000 | |
| SRP219564 | MGST2 | 4258 | RNAseq | -1.4155 | 0.0022 | |
| TCGA | MGST2 | 4258 | RNAseq | -0.0528 | 0.5563 |
Upregulated datasets: 0; Downregulated datasets: 16.
Survival by MGST2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MGST2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MGST2 | 4258 | 0 | 14 | 16 | |
| GSE20123 | MGST2 | 4258 | 0 | 14 | 16 | |
| GSE43470 | MGST2 | 4258 | 0 | 13 | 30 | |
| GSE46452 | MGST2 | 4258 | 1 | 36 | 22 | |
| GSE47630 | MGST2 | 4258 | 0 | 22 | 18 | |
| GSE54993 | MGST2 | 4258 | 10 | 0 | 60 | |
| GSE54994 | MGST2 | 4258 | 2 | 11 | 40 | |
| GSE60625 | MGST2 | 4258 | 0 | 1 | 10 | |
| GSE74703 | MGST2 | 4258 | 0 | 11 | 25 | |
| GSE74704 | MGST2 | 4258 | 0 | 6 | 14 | |
| TCGA | MGST2 | 4258 | 11 | 31 | 54 |
Total number of gains: 24; Total number of losses: 159; Total Number of normals: 305.
Somatic mutations of MGST2:
Generating mutation plots.
Highly correlated genes for MGST2:
Showing top 20/1921 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MGST2 | CTTNBP2 | 0.859309 | 6 | 0 | 6 |
| MGST2 | C5orf66-AS1 | 0.855954 | 6 | 0 | 6 |
| MGST2 | SASH1 | 0.847508 | 11 | 0 | 11 |
| MGST2 | ACPP | 0.847016 | 10 | 0 | 10 |
| MGST2 | SLURP1 | 0.842311 | 10 | 0 | 10 |
| MGST2 | SNORA68 | 0.84175 | 4 | 0 | 4 |
| MGST2 | SCNN1B | 0.840512 | 10 | 0 | 10 |
| MGST2 | SLC16A6 | 0.83812 | 11 | 0 | 11 |
| MGST2 | RMND5B | 0.837989 | 11 | 0 | 11 |
| MGST2 | MPP7 | 0.833714 | 7 | 0 | 7 |
| MGST2 | FAM214A | 0.832685 | 6 | 0 | 6 |
| MGST2 | FAM3B | 0.831176 | 6 | 0 | 6 |
| MGST2 | PRSS27 | 0.830456 | 6 | 0 | 6 |
| MGST2 | EVPL | 0.830072 | 10 | 0 | 10 |
| MGST2 | RBM20 | 0.82469 | 4 | 0 | 4 |
| MGST2 | PITX1 | 0.824265 | 10 | 0 | 10 |
| MGST2 | CXCR2 | 0.824134 | 11 | 0 | 11 |
| MGST2 | SH3BGRL2 | 0.823926 | 8 | 0 | 8 |
| MGST2 | MAL | 0.823746 | 10 | 0 | 10 |
| MGST2 | SFTA2 | 0.823689 | 4 | 0 | 4 |
For details and further investigation, click here
