| Full name: activating transcription factor 1 | Alias Symbol: TREB36 | ||
| Type: protein-coding gene | Cytoband: 12q13.12 | ||
| Entrez ID: 466 | HGNC ID: HGNC:783 | Ensembl Gene: ENSG00000123268 | OMIM ID: 123803 |
| Drug and gene relationship at DGIdb | |||
ATF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04925 | Aldosterone synthesis and secretion | |
| hsa05166 | HTLV-I infection |
Expression of ATF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ATF1 | 466 | 222103_at | -0.2675 | 0.6826 | |
| GSE20347 | ATF1 | 466 | 222103_at | 0.2743 | 0.0791 | |
| GSE23400 | ATF1 | 466 | 222103_at | 0.2832 | 0.0010 | |
| GSE26886 | ATF1 | 466 | 222103_at | -0.1753 | 0.6419 | |
| GSE29001 | ATF1 | 466 | 222103_at | 0.5242 | 0.2877 | |
| GSE38129 | ATF1 | 466 | 222103_at | 0.3387 | 0.0020 | |
| GSE45670 | ATF1 | 466 | 222103_at | -0.0942 | 0.4571 | |
| GSE53622 | ATF1 | 466 | 8520 | -0.1539 | 0.0251 | |
| GSE53624 | ATF1 | 466 | 8520 | 0.0991 | 0.1576 | |
| GSE63941 | ATF1 | 466 | 222103_at | -0.1712 | 0.6964 | |
| GSE77861 | ATF1 | 466 | 222103_at | -0.1300 | 0.7139 | |
| GSE97050 | ATF1 | 466 | A_33_P3294252 | -0.1908 | 0.4780 | |
| SRP007169 | ATF1 | 466 | RNAseq | 0.6936 | 0.1070 | |
| SRP008496 | ATF1 | 466 | RNAseq | 0.8602 | 0.0037 | |
| SRP064894 | ATF1 | 466 | RNAseq | 0.0875 | 0.7260 | |
| SRP133303 | ATF1 | 466 | RNAseq | 0.6175 | 0.0000 | |
| SRP159526 | ATF1 | 466 | RNAseq | 0.0637 | 0.8343 | |
| SRP193095 | ATF1 | 466 | RNAseq | 0.1719 | 0.0640 | |
| SRP219564 | ATF1 | 466 | RNAseq | 0.2244 | 0.5199 | |
| TCGA | ATF1 | 466 | RNAseq | 0.1201 | 0.0333 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by ATF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ATF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ATF1 | 466 | 8 | 1 | 21 | |
| GSE20123 | ATF1 | 466 | 8 | 1 | 21 | |
| GSE43470 | ATF1 | 466 | 4 | 0 | 39 | |
| GSE46452 | ATF1 | 466 | 8 | 1 | 50 | |
| GSE47630 | ATF1 | 466 | 11 | 2 | 27 | |
| GSE54993 | ATF1 | 466 | 0 | 5 | 65 | |
| GSE54994 | ATF1 | 466 | 4 | 1 | 48 | |
| GSE60625 | ATF1 | 466 | 0 | 0 | 11 | |
| GSE74703 | ATF1 | 466 | 4 | 0 | 32 | |
| GSE74704 | ATF1 | 466 | 5 | 1 | 14 | |
| TCGA | ATF1 | 466 | 14 | 11 | 71 |
Total number of gains: 66; Total number of losses: 23; Total Number of normals: 399.
Somatic mutations of ATF1:
Generating mutation plots.
Highly correlated genes for ATF1:
Showing top 20/788 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ATF1 | PSMD1 | 0.820685 | 3 | 0 | 3 |
| ATF1 | RAB9A | 0.816787 | 3 | 0 | 3 |
| ATF1 | MRPL37 | 0.80376 | 3 | 0 | 3 |
| ATF1 | CDIPT | 0.800456 | 3 | 0 | 3 |
| ATF1 | APIP | 0.777885 | 3 | 0 | 3 |
| ATF1 | ZNF394 | 0.770165 | 3 | 0 | 3 |
| ATF1 | TMEM150C | 0.765474 | 3 | 0 | 3 |
| ATF1 | PUM2 | 0.75539 | 3 | 0 | 3 |
| ATF1 | XRCC5 | 0.75173 | 3 | 0 | 3 |
| ATF1 | IFT20 | 0.746951 | 3 | 0 | 3 |
| ATF1 | PPM1L | 0.74436 | 3 | 0 | 3 |
| ATF1 | PSEN1 | 0.744174 | 3 | 0 | 3 |
| ATF1 | ARL5B | 0.742807 | 3 | 0 | 3 |
| ATF1 | STOML2 | 0.740473 | 4 | 0 | 4 |
| ATF1 | VPS36 | 0.73874 | 3 | 0 | 3 |
| ATF1 | ADH1C | 0.738256 | 3 | 0 | 3 |
| ATF1 | CPT2 | 0.734969 | 3 | 0 | 3 |
| ATF1 | C2orf68 | 0.728495 | 3 | 0 | 3 |
| ATF1 | MRPS27 | 0.727732 | 3 | 0 | 3 |
| ATF1 | GATAD1 | 0.727485 | 3 | 0 | 3 |
For details and further investigation, click here
