| Full name: purine rich element binding protein A | Alias Symbol: PURALPHA|PUR1|PUR-ALPHA | ||
| Type: protein-coding gene | Cytoband: 5q31.3 | ||
| Entrez ID: 5813 | HGNC ID: HGNC:9701 | Ensembl Gene: ENSG00000185129 | OMIM ID: 600473 |
| Drug and gene relationship at DGIdb | |||
Expression of PURA:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PURA | 5813 | 204020_at | -0.4052 | 0.4235 | |
| GSE20347 | PURA | 5813 | 204020_at | -0.3548 | 0.0439 | |
| GSE23400 | PURA | 5813 | 204020_at | -0.2789 | 0.0009 | |
| GSE26886 | PURA | 5813 | 204020_at | -0.2768 | 0.2560 | |
| GSE29001 | PURA | 5813 | 204020_at | -0.2278 | 0.4626 | |
| GSE38129 | PURA | 5813 | 204020_at | -0.5683 | 0.0001 | |
| GSE45670 | PURA | 5813 | 204020_at | -0.3529 | 0.0224 | |
| GSE53622 | PURA | 5813 | 3841 | -0.6013 | 0.0000 | |
| GSE53624 | PURA | 5813 | 21456 | -0.5267 | 0.0000 | |
| GSE63941 | PURA | 5813 | 204020_at | -0.3629 | 0.3654 | |
| GSE77861 | PURA | 5813 | 204020_at | -0.2852 | 0.1362 | |
| GSE97050 | PURA | 5813 | A_33_P3411296 | -0.4239 | 0.2680 | |
| SRP007169 | PURA | 5813 | RNAseq | -0.4044 | 0.2203 | |
| SRP008496 | PURA | 5813 | RNAseq | -0.3733 | 0.0170 | |
| SRP064894 | PURA | 5813 | RNAseq | -0.0311 | 0.8212 | |
| SRP133303 | PURA | 5813 | RNAseq | 0.0566 | 0.8287 | |
| SRP159526 | PURA | 5813 | RNAseq | -0.1885 | 0.6067 | |
| SRP193095 | PURA | 5813 | RNAseq | -0.4861 | 0.0000 | |
| SRP219564 | PURA | 5813 | RNAseq | 0.0205 | 0.9453 | |
| TCGA | PURA | 5813 | RNAseq | -0.2023 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by PURA expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PURA:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PURA | 5813 | 3 | 11 | 16 | |
| GSE20123 | PURA | 5813 | 4 | 11 | 15 | |
| GSE43470 | PURA | 5813 | 4 | 8 | 31 | |
| GSE46452 | PURA | 5813 | 0 | 27 | 32 | |
| GSE47630 | PURA | 5813 | 0 | 20 | 20 | |
| GSE54993 | PURA | 5813 | 9 | 1 | 60 | |
| GSE54994 | PURA | 5813 | 2 | 14 | 37 | |
| GSE60625 | PURA | 5813 | 0 | 0 | 11 | |
| GSE74703 | PURA | 5813 | 3 | 6 | 27 | |
| GSE74704 | PURA | 5813 | 3 | 5 | 12 | |
| TCGA | PURA | 5813 | 4 | 37 | 55 |
Total number of gains: 32; Total number of losses: 140; Total Number of normals: 316.
Somatic mutations of PURA:
Generating mutation plots.
Highly correlated genes for PURA:
Showing top 20/914 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PURA | IGIP | 0.808615 | 8 | 0 | 8 |
| PURA | KATNAL1 | 0.783056 | 3 | 0 | 3 |
| PURA | PHF2 | 0.774894 | 3 | 0 | 3 |
| PURA | PLEKHF2 | 0.759975 | 3 | 0 | 3 |
| PURA | ENSA | 0.757514 | 3 | 0 | 3 |
| PURA | LRFN5 | 0.747283 | 3 | 0 | 3 |
| PURA | ZNF354C | 0.745076 | 3 | 0 | 3 |
| PURA | ZNF467 | 0.742975 | 3 | 0 | 3 |
| PURA | SNX14 | 0.7372 | 3 | 0 | 3 |
| PURA | SCML1 | 0.732601 | 3 | 0 | 3 |
| PURA | C5orf24 | 0.728457 | 8 | 0 | 6 |
| PURA | TNRC6A | 0.725341 | 3 | 0 | 3 |
| PURA | CDS2 | 0.722019 | 3 | 0 | 3 |
| PURA | ALDH1A2 | 0.716718 | 3 | 0 | 3 |
| PURA | SCAMP1 | 0.714196 | 3 | 0 | 3 |
| PURA | RAB23 | 0.707107 | 3 | 0 | 3 |
| PURA | ZNF382 | 0.70336 | 3 | 0 | 3 |
| PURA | ESYT2 | 0.698758 | 4 | 0 | 3 |
| PURA | PLEKHH2 | 0.698128 | 3 | 0 | 3 |
| PURA | WDR20 | 0.697828 | 3 | 0 | 3 |
For details and further investigation, click here
