| Full name: pleckstrin homology, MyTH4 and FERM domain containing H2 | Alias Symbol: KIAA2028|PLEKHH1L | ||
| Type: protein-coding gene | Cytoband: 2p21 | ||
| Entrez ID: 130271 | HGNC ID: HGNC:30506 | Ensembl Gene: ENSG00000152527 | OMIM ID: 612723 |
| Drug and gene relationship at DGIdb | |||
Expression of PLEKHH2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLEKHH2 | 130271 | 227148_at | -1.5429 | 0.0372 | |
| GSE26886 | PLEKHH2 | 130271 | 227148_at | 0.7809 | 0.0325 | |
| GSE45670 | PLEKHH2 | 130271 | 227148_at | -1.9906 | 0.0000 | |
| GSE53622 | PLEKHH2 | 130271 | 21271 | -0.8562 | 0.0000 | |
| GSE53624 | PLEKHH2 | 130271 | 21271 | -0.8011 | 0.0000 | |
| GSE63941 | PLEKHH2 | 130271 | 227148_at | -3.0547 | 0.0044 | |
| GSE77861 | PLEKHH2 | 130271 | 227148_at | 0.3084 | 0.0556 | |
| GSE97050 | PLEKHH2 | 130271 | A_33_P3315719 | -0.9523 | 0.1313 | |
| SRP007169 | PLEKHH2 | 130271 | RNAseq | 1.2834 | 0.0050 | |
| SRP008496 | PLEKHH2 | 130271 | RNAseq | 1.1453 | 0.0025 | |
| SRP064894 | PLEKHH2 | 130271 | RNAseq | -0.5974 | 0.0586 | |
| SRP133303 | PLEKHH2 | 130271 | RNAseq | -0.4240 | 0.1249 | |
| SRP159526 | PLEKHH2 | 130271 | RNAseq | -0.6483 | 0.0754 | |
| SRP193095 | PLEKHH2 | 130271 | RNAseq | 0.5114 | 0.0038 | |
| SRP219564 | PLEKHH2 | 130271 | RNAseq | -0.3575 | 0.5059 | |
| TCGA | PLEKHH2 | 130271 | RNAseq | -0.2825 | 0.0638 |
Upregulated datasets: 2; Downregulated datasets: 3.
Survival by PLEKHH2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLEKHH2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLEKHH2 | 130271 | 11 | 1 | 18 | |
| GSE20123 | PLEKHH2 | 130271 | 10 | 1 | 19 | |
| GSE43470 | PLEKHH2 | 130271 | 4 | 0 | 39 | |
| GSE46452 | PLEKHH2 | 130271 | 1 | 4 | 54 | |
| GSE47630 | PLEKHH2 | 130271 | 7 | 0 | 33 | |
| GSE54993 | PLEKHH2 | 130271 | 0 | 5 | 65 | |
| GSE54994 | PLEKHH2 | 130271 | 10 | 0 | 43 | |
| GSE60625 | PLEKHH2 | 130271 | 0 | 3 | 8 | |
| GSE74703 | PLEKHH2 | 130271 | 4 | 0 | 32 | |
| GSE74704 | PLEKHH2 | 130271 | 10 | 1 | 9 | |
| TCGA | PLEKHH2 | 130271 | 36 | 2 | 58 |
Total number of gains: 93; Total number of losses: 17; Total Number of normals: 378.
Somatic mutations of PLEKHH2:
Generating mutation plots.
Highly correlated genes for PLEKHH2:
Showing top 20/735 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLEKHH2 | SORCS1 | 0.775201 | 3 | 0 | 3 |
| PLEKHH2 | FXYD1 | 0.762006 | 3 | 0 | 3 |
| PLEKHH2 | COL21A1 | 0.758949 | 3 | 0 | 3 |
| PLEKHH2 | NDNF | 0.750279 | 3 | 0 | 3 |
| PLEKHH2 | GFRA1 | 0.740944 | 5 | 0 | 5 |
| PLEKHH2 | GCC2 | 0.737902 | 3 | 0 | 3 |
| PLEKHH2 | CLN5 | 0.735087 | 3 | 0 | 3 |
| PLEKHH2 | PEG3 | 0.727499 | 4 | 0 | 4 |
| PLEKHH2 | NPY1R | 0.722316 | 4 | 0 | 4 |
| PLEKHH2 | MECP2 | 0.718726 | 3 | 0 | 3 |
| PLEKHH2 | SYNC | 0.716896 | 4 | 0 | 4 |
| PLEKHH2 | MYRIP | 0.715616 | 4 | 0 | 3 |
| PLEKHH2 | DTNA | 0.713683 | 4 | 0 | 4 |
| PLEKHH2 | LETMD1 | 0.711341 | 3 | 0 | 3 |
| PLEKHH2 | EP400 | 0.709645 | 3 | 0 | 3 |
| PLEKHH2 | FNDC5 | 0.70647 | 3 | 0 | 3 |
| PLEKHH2 | BCKDHB | 0.706172 | 4 | 0 | 4 |
| PLEKHH2 | PLEKHA3 | 0.705799 | 3 | 0 | 3 |
| PLEKHH2 | TCEAL1 | 0.705241 | 5 | 0 | 5 |
| PLEKHH2 | SH3BGR | 0.702632 | 5 | 0 | 5 |
For details and further investigation, click here
