| Full name: mediator of DNA damage checkpoint 1 | Alias Symbol: NFBD1|KIAA0170|Em:AB023051.5 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 9656 | HGNC ID: HGNC:21163 | Ensembl Gene: ENSG00000137337 | OMIM ID: 607593 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MDC1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MDC1 | 9656 | 203062_s_at | 0.6042 | 0.1545 | |
| GSE20347 | MDC1 | 9656 | 203061_s_at | 0.2792 | 0.0005 | |
| GSE23400 | MDC1 | 9656 | 203061_s_at | 0.1266 | 0.0027 | |
| GSE26886 | MDC1 | 9656 | 203062_s_at | 1.6427 | 0.0000 | |
| GSE29001 | MDC1 | 9656 | 203062_s_at | 1.1622 | 0.0007 | |
| GSE38129 | MDC1 | 9656 | 203062_s_at | 1.0032 | 0.0000 | |
| GSE45670 | MDC1 | 9656 | 203062_s_at | 0.1440 | 0.5156 | |
| GSE53622 | MDC1 | 9656 | 121478 | 0.5185 | 0.0000 | |
| GSE53624 | MDC1 | 9656 | 121478 | 0.7556 | 0.0000 | |
| GSE63941 | MDC1 | 9656 | 203062_s_at | 0.3154 | 0.5783 | |
| GSE77861 | MDC1 | 9656 | 203061_s_at | 0.2664 | 0.0439 | |
| GSE97050 | MDC1 | 9656 | A_23_P19455 | 0.0758 | 0.7446 | |
| SRP007169 | MDC1 | 9656 | RNAseq | 3.0627 | 0.0000 | |
| SRP008496 | MDC1 | 9656 | RNAseq | 3.7068 | 0.0000 | |
| SRP064894 | MDC1 | 9656 | RNAseq | 0.7360 | 0.0013 | |
| SRP133303 | MDC1 | 9656 | RNAseq | 0.5370 | 0.0005 | |
| SRP159526 | MDC1 | 9656 | RNAseq | 0.6724 | 0.0044 | |
| SRP193095 | MDC1 | 9656 | RNAseq | 0.7955 | 0.0000 | |
| SRP219564 | MDC1 | 9656 | RNAseq | 0.3377 | 0.1330 | |
| TCGA | MDC1 | 9656 | RNAseq | 0.1294 | 0.0245 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by MDC1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MDC1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MDC1 | 9656 | 5 | 1 | 24 | |
| GSE20123 | MDC1 | 9656 | 5 | 1 | 24 | |
| GSE43470 | MDC1 | 9656 | 5 | 1 | 37 | |
| GSE46452 | MDC1 | 9656 | 1 | 10 | 48 | |
| GSE47630 | MDC1 | 9656 | 7 | 3 | 30 | |
| GSE54993 | MDC1 | 9656 | 2 | 1 | 67 | |
| GSE54994 | MDC1 | 9656 | 11 | 4 | 38 | |
| GSE60625 | MDC1 | 9656 | 0 | 1 | 10 | |
| GSE74703 | MDC1 | 9656 | 5 | 0 | 31 | |
| GSE74704 | MDC1 | 9656 | 2 | 0 | 18 | |
| TCGA | MDC1 | 9656 | 18 | 16 | 62 |
Total number of gains: 61; Total number of losses: 38; Total Number of normals: 389.
Somatic mutations of MDC1:
Generating mutation plots.
Highly correlated genes for MDC1:
Showing top 20/520 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MDC1 | TIGD7 | 0.730328 | 3 | 0 | 3 |
| MDC1 | SDCCAG8 | 0.727597 | 5 | 0 | 4 |
| MDC1 | TMEM263 | 0.713317 | 6 | 0 | 6 |
| MDC1 | FBRSL1 | 0.702793 | 4 | 0 | 3 |
| MDC1 | TAF5L | 0.689765 | 7 | 0 | 7 |
| MDC1 | SMPD4 | 0.689692 | 3 | 0 | 3 |
| MDC1 | CBX3 | 0.689301 | 10 | 0 | 9 |
| MDC1 | CDCA7L | 0.686775 | 7 | 0 | 7 |
| MDC1 | ZNF697 | 0.684832 | 5 | 0 | 4 |
| MDC1 | HOMER1 | 0.680093 | 4 | 0 | 3 |
| MDC1 | OSBPL11 | 0.675167 | 3 | 0 | 3 |
| MDC1 | RBM25 | 0.670908 | 3 | 0 | 3 |
| MDC1 | ICE1 | 0.669674 | 9 | 0 | 8 |
| MDC1 | PRPF19 | 0.66515 | 6 | 0 | 4 |
| MDC1 | CCDC122 | 0.664899 | 3 | 0 | 3 |
| MDC1 | CECR2 | 0.66479 | 4 | 0 | 3 |
| MDC1 | MLF1 | 0.663794 | 9 | 0 | 9 |
| MDC1 | DVL2 | 0.662653 | 5 | 0 | 4 |
| MDC1 | TOX2 | 0.661809 | 4 | 0 | 3 |
| MDC1 | ZNF526 | 0.659781 | 3 | 0 | 3 |
For details and further investigation, click here
