POLR3K

 

Full name: RNA polymerase III subunit K Alias Symbol: RPC11
Type: protein-coding gene Cytoband: 16p13.3
Entrez ID: 51728 HGNC ID: HGNC:14121 Ensembl Gene: ENSG00000161980 OMIM ID: 606007
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of POLR3K:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 POLR3K 51728 218866_s_at 0.5997 0.4687
GSE20347 POLR3K 51728 218866_s_at 0.8212 0.0004
GSE23400 POLR3K 51728 218866_s_at 0.4218 0.0000
GSE26886 POLR3K 51728 218866_s_at 0.6886 0.0018
GSE29001 POLR3K 51728 218866_s_at 0.7234 0.1006
GSE38129 POLR3K 51728 218866_s_at 0.7686 0.0001
GSE45670 POLR3K 51728 218866_s_at 0.7870 0.0005
GSE53622 POLR3K 51728 71999 0.3762 0.0000
GSE53624 POLR3K 51728 71999 0.6624 0.0000
GSE63941 POLR3K 51728 218866_s_at 0.7648 0.0714
GSE77861 POLR3K 51728 218866_s_at 0.3460 0.2498
GSE97050 POLR3K 51728 A_24_P382001 0.4969 0.1782
SRP007169 POLR3K 51728 RNAseq 0.7630 0.0619
SRP008496 POLR3K 51728 RNAseq 0.7692 0.0147
SRP064894 POLR3K 51728 RNAseq 0.6801 0.0060
SRP133303 POLR3K 51728 RNAseq 0.6961 0.0067
SRP159526 POLR3K 51728 RNAseq 0.5952 0.1555
SRP193095 POLR3K 51728 RNAseq 0.2818 0.0106
SRP219564 POLR3K 51728 RNAseq 0.7155 0.0542
TCGA POLR3K 51728 RNAseq 0.2776 0.0020

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by POLR3K expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of POLR3K:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 POLR3K 51728 5 5 20
GSE20123 POLR3K 51728 5 4 21
GSE43470 POLR3K 51728 3 8 32
GSE46452 POLR3K 51728 38 1 20
GSE47630 POLR3K 51728 12 7 21
GSE54993 POLR3K 51728 3 5 62
GSE54994 POLR3K 51728 4 10 39
GSE60625 POLR3K 51728 4 0 7
GSE74703 POLR3K 51728 3 6 27
GSE74704 POLR3K 51728 3 2 15
TCGA POLR3K 51728 20 15 61

Total number of gains: 100; Total number of losses: 63; Total Number of normals: 325.  

 

Somatic mutations of POLR3K:

 

Generating mutation plots.

 

Highly correlated genes for POLR3K:

 

Showing top 20/1275 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
POLR3KSNRNP250.7379461209
POLR3KDCTPP10.73095113010
POLR3KZFP69B0.697973404
POLR3KMRPL280.6961310010
POLR3KCDK40.68408612011
POLR3KAIFM10.678308807
POLR3KNMRAL10.67594605
POLR3KTHOC60.6753991009
POLR3KMAF10.67468303
POLR3KCCDC770.674498606
POLR3KDDX200.672148403
POLR3KKIF220.66801812011
POLR3KMRPS340.66699113012
POLR3KGTPBP30.666003604
POLR3KNUDCD10.665074403
POLR3KTMEM2160.664813504
POLR3KEDEM20.663537908
POLR3KRUVBL10.66335212011
POLR3KALG10.663268505
POLR3KNUP930.6622812010

For details and further investigation, click here