| Full name: reelin | Alias Symbol: RL|PRO1598 | ||
| Type: protein-coding gene | Cytoband: 7q22.1 | ||
| Entrez ID: 5649 | HGNC ID: HGNC:9957 | Ensembl Gene: ENSG00000189056 | OMIM ID: 600514 |
| Drug and gene relationship at DGIdb | |||
RELN involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04151 | PI3K-Akt signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of RELN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RELN | 5649 | 205923_at | -0.8722 | 0.1071 | |
| GSE20347 | RELN | 5649 | 205923_at | -0.0892 | 0.5252 | |
| GSE23400 | RELN | 5649 | 205923_at | -0.2428 | 0.0000 | |
| GSE26886 | RELN | 5649 | 205923_at | 0.9781 | 0.1654 | |
| GSE29001 | RELN | 5649 | 205923_at | -0.2168 | 0.2809 | |
| GSE38129 | RELN | 5649 | 205923_at | -0.9230 | 0.0016 | |
| GSE45670 | RELN | 5649 | 205923_at | -1.2206 | 0.0000 | |
| GSE53622 | RELN | 5649 | 32158 | -1.5750 | 0.0000 | |
| GSE53624 | RELN | 5649 | 32158 | -0.9988 | 0.0000 | |
| GSE63941 | RELN | 5649 | 205923_at | -0.7664 | 0.1232 | |
| GSE77861 | RELN | 5649 | 205923_at | -0.1496 | 0.1360 | |
| GSE97050 | RELN | 5649 | A_33_P3323959 | -0.0968 | 0.8503 | |
| SRP007169 | RELN | 5649 | RNAseq | 0.4965 | 0.3723 | |
| SRP064894 | RELN | 5649 | RNAseq | -0.3042 | 0.5805 | |
| SRP133303 | RELN | 5649 | RNAseq | -1.8848 | 0.0009 | |
| SRP159526 | RELN | 5649 | RNAseq | -0.1745 | 0.7971 | |
| SRP219564 | RELN | 5649 | RNAseq | -0.0053 | 0.9958 | |
| TCGA | RELN | 5649 | RNAseq | -1.6367 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by RELN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RELN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RELN | 5649 | 13 | 0 | 17 | |
| GSE20123 | RELN | 5649 | 13 | 0 | 17 | |
| GSE43470 | RELN | 5649 | 6 | 1 | 36 | |
| GSE46452 | RELN | 5649 | 10 | 1 | 48 | |
| GSE47630 | RELN | 5649 | 7 | 3 | 30 | |
| GSE54993 | RELN | 5649 | 1 | 10 | 59 | |
| GSE54994 | RELN | 5649 | 16 | 3 | 34 | |
| GSE60625 | RELN | 5649 | 0 | 0 | 11 | |
| GSE74703 | RELN | 5649 | 6 | 1 | 29 | |
| GSE74704 | RELN | 5649 | 9 | 0 | 11 | |
| TCGA | RELN | 5649 | 54 | 6 | 36 |
Total number of gains: 135; Total number of losses: 25; Total Number of normals: 328.
Somatic mutations of RELN:
Generating mutation plots.
Highly correlated genes for RELN:
Showing top 20/867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RELN | UBXN10 | 0.831053 | 3 | 0 | 3 |
| RELN | SORCS1 | 0.809366 | 3 | 0 | 3 |
| RELN | RNASE4 | 0.801291 | 4 | 0 | 4 |
| RELN | ANGPTL1 | 0.768061 | 4 | 0 | 4 |
| RELN | C1QTNF7 | 0.767219 | 4 | 0 | 4 |
| RELN | CHRDL1 | 0.761591 | 6 | 0 | 6 |
| RELN | RASSF3 | 0.761237 | 3 | 0 | 3 |
| RELN | BHMT2 | 0.749297 | 8 | 0 | 8 |
| RELN | AOC3 | 0.741002 | 7 | 0 | 7 |
| RELN | DIXDC1 | 0.740063 | 9 | 0 | 9 |
| RELN | CDH19 | 0.738849 | 8 | 0 | 8 |
| RELN | CNTN4 | 0.733812 | 4 | 0 | 3 |
| RELN | LYVE1 | 0.732952 | 8 | 0 | 7 |
| RELN | LRRN4CL | 0.731729 | 5 | 0 | 5 |
| RELN | AGTR1 | 0.730087 | 9 | 0 | 8 |
| RELN | S1PR1 | 0.728768 | 8 | 0 | 8 |
| RELN | GNG11 | 0.726882 | 9 | 0 | 9 |
| RELN | ADAMTS9-AS2 | 0.72305 | 4 | 0 | 3 |
| RELN | NEGR1 | 0.720142 | 6 | 0 | 5 |
| RELN | ARHGAP6 | 0.717317 | 9 | 0 | 8 |
For details and further investigation, click here
