| Full name: ret proto-oncogene | Alias Symbol: PTC|CDHF12|RET51|CDHR16 | ||
| Type: protein-coding gene | Cytoband: 10q11.21 | ||
| Entrez ID: 5979 | HGNC ID: HGNC:9967 | Ensembl Gene: ENSG00000165731 | OMIM ID: 164761 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
RET involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa05200 | Pathways in cancer | |
| hsa05216 | Thyroid cancer |
Expression of RET:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RET | 5979 | 205879_x_at | -0.0406 | 0.9053 | |
| GSE20347 | RET | 5979 | 205879_x_at | 0.0725 | 0.5089 | |
| GSE23400 | RET | 5979 | 205879_x_at | -0.0354 | 0.4131 | |
| GSE26886 | RET | 5979 | 205879_x_at | -0.0558 | 0.7181 | |
| GSE29001 | RET | 5979 | 205879_x_at | -0.0651 | 0.7143 | |
| GSE38129 | RET | 5979 | 205879_x_at | 0.0332 | 0.7932 | |
| GSE45670 | RET | 5979 | 205879_x_at | 0.0175 | 0.8893 | |
| GSE53622 | RET | 5979 | 71784 | 0.3804 | 0.0027 | |
| GSE53624 | RET | 5979 | 71784 | 0.6549 | 0.0000 | |
| GSE63941 | RET | 5979 | 205879_x_at | 0.1092 | 0.7120 | |
| GSE77861 | RET | 5979 | 205879_x_at | -0.0685 | 0.6300 | |
| SRP133303 | RET | 5979 | RNAseq | 1.2007 | 0.0294 | |
| SRP159526 | RET | 5979 | RNAseq | 1.5264 | 0.0063 | |
| SRP219564 | RET | 5979 | RNAseq | 0.1439 | 0.8531 | |
| TCGA | RET | 5979 | RNAseq | -0.6730 | 0.0260 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by RET expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RET:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RET | 5979 | 2 | 6 | 22 | |
| GSE20123 | RET | 5979 | 3 | 5 | 22 | |
| GSE43470 | RET | 5979 | 1 | 6 | 36 | |
| GSE46452 | RET | 5979 | 0 | 13 | 46 | |
| GSE47630 | RET | 5979 | 4 | 12 | 24 | |
| GSE54993 | RET | 5979 | 9 | 0 | 61 | |
| GSE54994 | RET | 5979 | 2 | 10 | 41 | |
| GSE60625 | RET | 5979 | 0 | 0 | 11 | |
| GSE74703 | RET | 5979 | 1 | 3 | 32 | |
| GSE74704 | RET | 5979 | 2 | 4 | 14 | |
| TCGA | RET | 5979 | 15 | 20 | 61 |
Total number of gains: 39; Total number of losses: 79; Total Number of normals: 370.
Somatic mutations of RET:
Generating mutation plots.
Highly correlated genes for RET:
Showing top 20/623 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RET | JAK3 | 0.785007 | 3 | 0 | 3 |
| RET | CDC25C | 0.740013 | 3 | 0 | 3 |
| RET | NEUROD2 | 0.699769 | 3 | 0 | 3 |
| RET | KCNB2 | 0.687748 | 5 | 0 | 5 |
| RET | FSTL4 | 0.677666 | 3 | 0 | 3 |
| RET | TMPRSS5 | 0.677665 | 6 | 0 | 6 |
| RET | CBL | 0.677419 | 3 | 0 | 3 |
| RET | NHLH1 | 0.674806 | 3 | 0 | 3 |
| RET | RNF185-AS1 | 0.669355 | 5 | 0 | 4 |
| RET | KIR3DL3 | 0.655674 | 5 | 0 | 5 |
| RET | HAND1 | 0.652089 | 6 | 0 | 5 |
| RET | SCN8A | 0.65144 | 3 | 0 | 3 |
| RET | FRAS1 | 0.647232 | 3 | 0 | 3 |
| RET | GRM3 | 0.646965 | 3 | 0 | 3 |
| RET | GALNT8 | 0.646761 | 4 | 0 | 3 |
| RET | PRORY | 0.646343 | 3 | 0 | 3 |
| RET | KHDRBS2 | 0.644997 | 4 | 0 | 3 |
| RET | CNTF | 0.644342 | 3 | 0 | 3 |
| RET | OR51B5 | 0.644243 | 3 | 0 | 3 |
| RET | RGS6 | 0.643023 | 3 | 0 | 3 |
For details and further investigation, click here
